消化系统毒理学生物标志物研究新进展

王洁; 夏振娜; 车爱萍; 袁伯俊; 陆国才

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消化系统毒理学生物标志物研究新进展

王洁, 夏振娜, 车爱萍, 袁伯俊, 陆国才

文章导航 > 药学实践与服务 > 2011 > 29(4): 247-250

王洁, 夏振娜, 车爱萍, 袁伯俊, 陆国才. 消化系统毒理学生物标志物研究新进展[J]. 药学实践与服务, 2011, 29(4): 247-250.

引用本文:

王洁, 夏振娜, 车爱萍, 袁伯俊, 陆国才. 消化系统毒理学生物标志物研究新进展[J]. 药学实践与服务, 2011, 29(4): 247-250.

WANG Jie, XIA Zhen-na, CHE Ai-ping, YUAN Bo-jun, LU Guo-cai. Progress on the study of toxicologic biomarkers in digestive system[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(4): 247-250.

Citation:

WANG Jie, XIA Zhen-na, CHE Ai-ping, YUAN Bo-jun, LU Guo-cai. Progress on the study of toxicologic biomarkers in digestive system[J]. Journal of Pharmaceutical Practice and Service, 2011, 29(4): 247-250.

消化系统毒理学生物标志物研究新进展

第二军医大学新药评价中心,上海 200433

基金项目: "重大新药创制"科技重大专项 (2008ZXJ09014-0095, 2009ZX09301-011).

Progress on the study of toxicologic biomarkers in digestive system

Center for New Drug Evaluation, Second Military Medical University, Shanghai 200433,China

摘要: 毒理学生物标志物是机体对化学物质毒性剂量暴露后的生物学变化,可特异性地反映毒性效应。对毒理学生物标志物进行全面评估,并尽快应用于临床,可以有效地减少药物研发风险。新近发现与消化系统毒理学研究有关的生物标志物有肠脂肪酸结合蛋白、二胺氧化酶、牛磺酸、山梨醇脱氢酶、羧酸酯酶-2、转化生长因子β1、组织多肽特异性抗原、再生基因蛋白Reg4、S100蛋白、血清糖蛋白YKL-40等。
- 生物标志物 /
- 消化系统 /
- 毒理学
Abstract: Toxicologic biomarkers,indicating specific toxic effects, are biological changes of body when exposured to toxic doses of chemicals. Comprehensive assessment and clinical application of toxicologic biomarkers at early stage could effectively reduce the risk in drug research and development. Recently discovered toxicological biomarkers of the digestive system were intestinal fatty acid binding protein, diamine oxidase, taurine, sorbitol dehydrogenase, carboxylesterase-2, transforming growth factor β1, tissue polypeptide specific antigen, regenerating gene protein Reg4, S100 protein and serum glycoprotein YKL-40 etc.
- biomarkers /
- digestive system /
- toxicology

[1]	Walker CH, Hopkin SP, Sibly RM, et al. National Research Council. Committee on biological markers[J]. Environ Health Persp,1987, 74:3.
[2]	Liu RZ, Li XD, Godbout R. A novel fatty acid-binding protein (FABP) gene resulting from tandem gene duplication in mammals: transcription in rat retina and testis[J]. Genomics, 2008, 92: 436.
[3]	Vreugdenhil A, Wolters VM, Van den Neucker A, et al. 193 Enhanced I-FABP levels in children with celiac disease rapidly recover aAfter gluten free diet. Potential marker for diagnosis and follow-up of celiac disease[J]. Gastroenterology, 2009, 136: A36.
[4]	Luk GD, Vaughan WP, Burke PJ, et al. Diamine oxidase as a plasma marker of rat intestinal mucosaln injury and regeneration after administration of 1-β-d-arabinofuranosylcytosine[J]. Cancer Res,1981, 41:2334.
[5]	Kenji M, Yasuhide K, Hidenobu M, et al. Diamine oxidase, a plasma biomarker in rats to GI tract toxicity of oral uorouracil anti-cancer drugs[J]. Toxicology, 2006, 217:23.
[6]	Huang JS, Chuang LY, Gu JY. Effect of taurine on advanced glycation end products-induced hypertrophy in renal tubular epithelial cells[J]. Toxical Appl Pharm, 2008,233: 220.
[7]	Ghandforoush-Sattari M, Mashayekh S. Evaluation of taurine as a biomarker of liver damage in paracetamol poisoning[J]. Eur J Pharmacol, 2008, 581:171.
[8]	Ramaiah SK. A toxicologist guide to the diagnostic interpretation of hepatic biochemical parameters[J]. Toxicology. 2007, 45: 1551.
[9]	Ozer J, Ratner M, Shaw M, et al. The current state of serum biomarkers of hepatotoxicity[J]. Toxicology, 2008, 245: 194.
[10]	Allen C, Abdolsamad B, Philip M, et al. Hydrolysis of pyrethroids by human and rat tissues: Examination of intestinal liver and serum carboxylesterases[J]. Toxicol Appl Pharm, 2007, 221: 1.
[11]	Gressner S, Jafari ME, Frank Y, et al. Evaluation of serum percent trisialotransferrin as potential predictive biomarker of hepatocellular dedifferentiation in chronic liver disease[J]. Clin Chim Acta, 2009, 403:188.
[12]	蒋莹, 阿依吐拉. 转化生长因子β1和基质金属蛋白酶抑制因子β1在肝硬化组织中的表达及其临床意义[J]. 临床肝胆病杂志, 2009,25:39.
[13]	Duller P, Stiegler M, Schweiger T, et al. Sensitive serum parameters for hepatocellular carcinoma recurrence monitoring after liver transplantation: A case report[J]. Transpl P, 2007, 39:3281.
[14]	Takayama R, Nakagawa H, Sawaki A, et al. Serum tumor antigen Reg4 as a diagnostic biomarker in pancreatic ductal adenocarcinoma[J]. Gastroenterology, 2008, 134: A695.
[15]	Salama I, Malone PS, Mihaimeed F. A review of the S100 proteins in cancer[J]. Eur J Surg Onc, 2008, 34:357.
[16]	Oliveira-Cunha M, Siriwardena AK, Byers R. Molecular diagnosis in pancreatic cancer[J]. Diagn Hist, 2008, 14:214-222.
[17]	Kacira T, Hanimoglu H, Kucur M, et al. Elevated cerebrospinal fluid and serum YKL-40 levels are not associated with symptomatic vasospasm in patients with aneurysmal subarachnoid haemorrhage[J]. J Clin Neurosci, 2008,15:1011.
[18]	Scheer M, Wild S, Kuebler AC, et al. YKL-40 as prognostic biomarker in patients with oral cancer[J]. J Cranio Maxill Surg, 2008, 36: S190.
[19]	Jain KK. The Handbook of Biomarkers[M]. New York: Humana Press, 2010:1-84.
[20]	Azuaje F. Bioinformatics and Biomarker Discovery [M]. Chichester: Wiley-Blackwell, 2010:173.

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消化系统毒理学生物标志物研究新进展

第二军医大学新药评价中心,上海 200433

基金项目: "重大新药创制"科技重大专项 (2008ZXJ09014-0095, 2009ZX09301-011).

收稿日期: 2010-10-13
修回日期: 2010-12-02

关键词:

生物标志物 /

消化系统 /

毒理学

摘要: 毒理学生物标志物是机体对化学物质毒性剂量暴露后的生物学变化,可特异性地反映毒性效应。对毒理学生物标志物进行全面评估,并尽快应用于临床,可以有效地减少药物研发风险。新近发现与消化系统毒理学研究有关的生物标志物有肠脂肪酸结合蛋白、二胺氧化酶、牛磺酸、山梨醇脱氢酶、羧酸酯酶-2、转化生长因子β1、组织多肽特异性抗原、再生基因蛋白Reg4、S100蛋白、血清糖蛋白YKL-40等。