纳络酮对犬心肌腺苷酸环化酶活性的影响
Effect of naloxone on adenylcyclase activity of canine myocardium
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摘要: 本文通过体内及体外实验观察了纳络酮对正常、缺血和再灌注心肌腺苷酸环化酶(AC)活性的影响。其结果表明:静脉注射纳络因(1mg.kg-1)可以明显降低缺血、再灌注心肌AC活性(P<0.01,P<0.05);但纳络酮在体外对正常、缺血和再灌注心肌组织匀浆AC活性无明显抑制作用(P>0.05)。提示:纳络酮本身对AC活性无直接抑制作用,它降低缺血、再灌注心肌AC活性可能与酶前调节有关。Abstract: To elucidate the effect of naloxone on adenylcyclase(AC) of canine myocardium,the adenylcyclase activities of non-ischemic, ischemic and reper fused myocardium were assayed respectively in vivo and in vitro.It was found that intravascular administration of naloxone(1mg.kg-1) significantly decreased AC activities of ischemic and reper fused myocardium(p<0.01, p<0.05);but naloxone had no effect on AC activities in non-ischemic, ischemic and reperfused myocardium homogenate(p>0.05).It suggested that naloxone have no direct inhibiting effect on activity.
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Key words:
- myocardium /
- naloxone /
- adenylcyclase
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