2019 Vol. 37, No. 1
Display Method:
2019, 37(1): 1-4,31.
doi: 10.3969/j.issn.1006-0111.2019.01.001
Abstract:
The function of drugs is based on the interaction between drug molecules and their targets.Qualitative analysis and quantitative detection of drug-target interactions run through the whole process from drug discovery to clinical practice.After decade...
The function of drugs is based on the interaction between drug molecules and their targets.Qualitative analysis and quantitative detection of drug-target interactions run through the whole process from drug discovery to clinical practice.After decade...
2019, 37(1): 5-8,13.
doi: 10.3969/j.issn.1006-0111.2019.01.002
Abstract:
The Hop plant (Humulus lupulus L., Cannabinaceae) is a dioeciou twining perennial.The relevant papers at home and abroad in recent years were reviewed and a summary analysis and induction were conducted to research the progress of hops and provide a ...
The Hop plant (Humulus lupulus L., Cannabinaceae) is a dioeciou twining perennial.The relevant papers at home and abroad in recent years were reviewed and a summary analysis and induction were conducted to research the progress of hops and provide a ...
2019, 37(1): 9-13.
doi: 10.3969/j.issn.1006-0111.2019.01.003
Abstract:
Eczema is a common clinical inflammatory skin disease characterized by severe itching and recurrent attacks.Its etiology is complex, including a variety of internal and external factors.The main mechanism is related to the imbalance of Th2 immune res...
Eczema is a common clinical inflammatory skin disease characterized by severe itching and recurrent attacks.Its etiology is complex, including a variety of internal and external factors.The main mechanism is related to the imbalance of Th2 immune res...
Establishment and evaluation of in vivo and in vitro D-galactose induced cognitive impairment models
2019, 37(1): 14-18,73.
doi: 10.3969/j.issn.1006-0111.2019.01.004
Abstract:
Objective To construct and explore the in vivo and in vitro D-galactose induced cognitive impairment models and evaluate the application value of the combined models in the study of cognitive impairments. Methods The cognitive impairment mice mode...
Objective To construct and explore the in vivo and in vitro D-galactose induced cognitive impairment models and evaluate the application value of the combined models in the study of cognitive impairments. Methods The cognitive impairment mice mode...
2019, 37(1): 19-22.
doi: 10.3969/j.issn.1006-0111.2019.01.005
Abstract:
Objective To develop a simple, rapid and sensitive method for the determination of major compounds from Gardenia jasminoides Ellis using liquid chromatography tandem mass spectrometry (LC-MS/MS). Methods The analysis was performed on Dikma Diamonsi...
Objective To develop a simple, rapid and sensitive method for the determination of major compounds from Gardenia jasminoides Ellis using liquid chromatography tandem mass spectrometry (LC-MS/MS). Methods The analysis was performed on Dikma Diamonsi...
2019, 37(1): 23-26.
doi: 10.3969/j.issn.1006-0111.2019.01.006
Abstract:
Objective To investigate the effects and mechanism of verbascoside on hypoxia-induced memory impairment. Methods The eight-arm maze was used to train mice's spatial memory ability. After successful training, mice were randomly divided into five gr...
Objective To investigate the effects and mechanism of verbascoside on hypoxia-induced memory impairment. Methods The eight-arm maze was used to train mice's spatial memory ability. After successful training, mice were randomly divided into five gr...
2019, 37(1): 27-31.
doi: 10.3969/j.issn.1006-0111.2019.01.007
Abstract:
Objective To establish a high-throughput in-vitro screening cell model for anti-atherosclerosis leading compounds. Methods Hypoxia response element (HRE) was cloned into a luciferase reporter vector, pGL3-Enhancer, to construct pGL3-HIF-1α-HRE. Th...
Objective To establish a high-throughput in-vitro screening cell model for anti-atherosclerosis leading compounds. Methods Hypoxia response element (HRE) was cloned into a luciferase reporter vector, pGL3-Enhancer, to construct pGL3-HIF-1α-HRE. Th...
2019, 37(1): 32-36,41.
doi: 10.3969/j.issn.1006-0111.2019.01.008
Abstract:
Objective To investigate the effect and mechanism of astragalus Ⅳ(AS-Ⅳ) on the expression of CCL18 in U937 macrophages. Methods The expression of CCL18 mRNA was detected by real time PCR. The expression of CCL18 protein was assessed by Elisa. The e...
Objective To investigate the effect and mechanism of astragalus Ⅳ(AS-Ⅳ) on the expression of CCL18 in U937 macrophages. Methods The expression of CCL18 mRNA was detected by real time PCR. The expression of CCL18 protein was assessed by Elisa. The e...
2019, 37(1): 37-41.
doi: 10.3969/j.issn.1006-0111.2019.01.009
Abstract:
Objective To establish a method for concentration determination of garlic saponins PIEB in the rat plasma and study the pharmacokinetics of PIEB. Methods The separation was performed on a reverse phase Athena C18-WP (50 mm×2.1 mm, 3 μm), with the m...
Objective To establish a method for concentration determination of garlic saponins PIEB in the rat plasma and study the pharmacokinetics of PIEB. Methods The separation was performed on a reverse phase Athena C18-WP (50 mm×2.1 mm, 3 μm), with the m...
2019, 37(1): 42-45,54.
doi: 10.3969/j.issn.1006-0111.2019.01.010
Abstract:
Objective To establish fingerprint of Hupulus lupulus by HPLC. Methods Diamonsil C18 column (250 mm×4.6 mm, 5 μm) was used. The mobile phase consisted of acetonitrile and 0.1% phosphoric acid, in gradient elution mode, detection wavelength was 358...
Objective To establish fingerprint of Hupulus lupulus by HPLC. Methods Diamonsil C18 column (250 mm×4.6 mm, 5 μm) was used. The mobile phase consisted of acetonitrile and 0.1% phosphoric acid, in gradient elution mode, detection wavelength was 358...
2019, 37(1): 46-50,68.
doi: 10.3969/j.issn.1006-0111.2019.01.011
Abstract:
Objective To prepare, investigate and optimize the drug stability of compound adapalene ointment. Methods The ointment containing adapalene and mupirocin were prepared with PEG400 and PEG3350 as matrix.Stress test was used to evaluate and optimize ...
Objective To prepare, investigate and optimize the drug stability of compound adapalene ointment. Methods The ointment containing adapalene and mupirocin were prepared with PEG400 and PEG3350 as matrix.Stress test was used to evaluate and optimize ...
2019, 37(1): 51-54.
doi: 10.3969/j.issn.1006-0111.2019.01.012
Abstract:
Objective To study the immunomodulatory effect of Yupingfeng polysaccharides on keratinocytes in vitro. Methods The effects of Yupingfeng polysaccharides on the expression of various inflammatory factors in the activated keratinocytes were detected...
Objective To study the immunomodulatory effect of Yupingfeng polysaccharides on keratinocytes in vitro. Methods The effects of Yupingfeng polysaccharides on the expression of various inflammatory factors in the activated keratinocytes were detected...
2019, 37(1): 55-58,85.
doi: 10.3969/j.issn.1006-0111.2019.01.013
Abstract:
Objective To improve the quality control standard of the hospital preparation Kechuan Liuwei oral liquid in Longhua Hospital. Methods TLC was used for qualitative identification of Scutellaria baicalensis Georgi and Asarum sieboldi Mig in the Kech...
Objective To improve the quality control standard of the hospital preparation Kechuan Liuwei oral liquid in Longhua Hospital. Methods TLC was used for qualitative identification of Scutellaria baicalensis Georgi and Asarum sieboldi Mig in the Kech...
2019, 37(1): 59-64.
doi: 10.3969/j.issn.1006-0111.2019.01.014
Abstract:
Objective To determine the water absorption coefficient of single-flavor root and rhizome Chinese herbal medicine pieces at room temperature, and guide the water addition in the decoction process of decocting machine of Chinese herbal. Methods The...
Objective To determine the water absorption coefficient of single-flavor root and rhizome Chinese herbal medicine pieces at room temperature, and guide the water addition in the decoction process of decocting machine of Chinese herbal. Methods The...
2019, 37(1): 65-68.
doi: 10.3969/j.issn.1006-0111.2019.01.015
Abstract:
Objective To analyze the effect of the molecular weight and viscosity of silicone rubber on the release of fluorouracil implants. Methods According to GN/T21863-2008 standard and Chinese Pharmacopoeia, the molecular weight and viscosity of differe...
Objective To analyze the effect of the molecular weight and viscosity of silicone rubber on the release of fluorouracil implants. Methods According to GN/T21863-2008 standard and Chinese Pharmacopoeia, the molecular weight and viscosity of differe...
2019, 37(1): 69-73.
doi: 10.3969/j.issn.1006-0111.2019.01.016
Abstract:
Objective To study the preparation and properties of alkalized shikonin liposome. Methods Alkalized shikonin was purified from extracts of radix lithospermi with an alkali solution and acid formulation, and then the alkalized shikonin liposome was ...
Objective To study the preparation and properties of alkalized shikonin liposome. Methods Alkalized shikonin was purified from extracts of radix lithospermi with an alkali solution and acid formulation, and then the alkalized shikonin liposome was ...
2019, 37(1): 74-76.
doi: 10.3969/j.issn.1006-0111.2019.01.017
Abstract:
Objective To investigate the preventive use of antibiotics for internal fixation as selective removal surgery during perioperative period. Methods The sex, age, routine blood examination data, preventive medications, secondary incision infection a...
Objective To investigate the preventive use of antibiotics for internal fixation as selective removal surgery during perioperative period. Methods The sex, age, routine blood examination data, preventive medications, secondary incision infection a...
2019, 37(1): 77-79,90.
doi: 10.3969/j.issn.1006-0111.2019.01.018
Abstract:
Objective To establish a method for determination and optimize the extraction process of the content of plantamajoside in plantain. Methods Plantamajoside content was determined by HPLC.The effects of ethanol concentration, ethanol amount and extra...
Objective To establish a method for determination and optimize the extraction process of the content of plantamajoside in plantain. Methods Plantamajoside content was determined by HPLC.The effects of ethanol concentration, ethanol amount and extra...
2019, 37(1): 80-85.
doi: 10.3969/j.issn.1006-0111.2019.01.019
Abstract:
Objective Diterpene ginkgolides meglumine injection (DGMI) is widely used in patients with stroke, but its efficacy and safety are not consistent. We performed a Meta-analysis to comprehensively evaluate the efficacy and safety of DGMI in acute isch...
Objective Diterpene ginkgolides meglumine injection (DGMI) is widely used in patients with stroke, but its efficacy and safety are not consistent. We performed a Meta-analysis to comprehensively evaluate the efficacy and safety of DGMI in acute isch...
2019, 37(1): 86-90.
doi: 10.3969/j.issn.1006-0111.2019.01.020
Abstract:
Objective To strengthen the system of drug supply chain collaborative service platform in drug supply, decrease drug inventory backlog, and improve the outpatient pharmacy management capacity in outpatient pharmacy. Methods Failure mode and effects...
Objective To strengthen the system of drug supply chain collaborative service platform in drug supply, decrease drug inventory backlog, and improve the outpatient pharmacy management capacity in outpatient pharmacy. Methods Failure mode and effects...
2019, 37(1): 91-93.
doi: 10.3969/j.issn.1006-0111.2019.01.021
Abstract:
Under the background of a series of reform policy, more and more hospitals chose the depth mode of drug supply chain to reform the drug procurement and management. The concept of depth of drug supply chain cooperation, and practice of cooperative eff...
Under the background of a series of reform policy, more and more hospitals chose the depth mode of drug supply chain to reform the drug procurement and management. The concept of depth of drug supply chain cooperation, and practice of cooperative eff...
2019, 37(1): 94-96.
doi: 10.3969/j.issn.1006-0111.2019.01.022
Abstract:
Objective To study the effects of different airway humidification fluid applied to non-invasive mechanical ventilation. Methods 121 cases of non-invasive mechanical ventilation admitted to the hospital from May 2016 to May 2017 were randomly divide...
Objective To study the effects of different airway humidification fluid applied to non-invasive mechanical ventilation. Methods 121 cases of non-invasive mechanical ventilation admitted to the hospital from May 2016 to May 2017 were randomly divide...
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