Message Board

Respected readers, authors and reviewers, you can add comments to this page on any questions about the contribution, review,        editing and publication of this journal. We will give you an answer as soon as possible. Thank you for your support!

Name
E-mail
Phone
Title
Content
Verification Code
x Close Forever Close
Volume 37 Issue 1
. 
Turn off MathJax
Article Contents
Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2019  >  37(1): 69-73

SHI Lei, YE Jun, SONG Lei. Preparation and properties of alkalized shikonin liposome[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(1): 69-73. doi: 10.3969/j.issn.1006-0111.2019.01.016
Citation: SHI Lei, YE Jun, SONG Lei. Preparation and properties of alkalized shikonin liposome[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(1): 69-73. doi: 10.3969/j.issn.1006-0111.2019.01.016
shu

Preparation and properties of alkalized shikonin liposome

doi: 10.3969/j.issn.1006-0111.2019.01.016
  • 1.

    Shanghai Jingan Institute for Food and Drug Control, Shanghai 200435, China

  • 2.

    Tongren Hospital Affiliated to School of Medicine, Shanghai Jiaotong University, Shanghai 200050, China

  • Received Date: 2018-07-22
  • Rev Recd Date: 2018-11-12
  • Objective To study the preparation and properties of alkalized shikonin liposome. Methods Alkalized shikonin was purified from extracts of radix lithospermi with an alkali solution and acid formulation, and then the alkalized shikonin liposome was prepared by ethanol injection.The morphology, particle size and Zeta potential were determined, and the encapsulation efficiency and the in vitro release property were investigated.The content of L-shikonin was also measured by High Performance Liquid Chromatography. Results Alkalized shikonin liposome presented even sphere and normal distribution with particle size of 104.2 nm.The Zeta potential was-14.8 mV.L-shikonin was linear in the range of 5-50 mg/L with the correlation coefficient 0.999 9.The encapsulation efficiency was 43.67%.The final release rate was 65.82%. Conclusion Alkalized shikonin liposome was prepared successfully with good entrapment efficiency and in vitro release property.
  • [1] DRAGICEVIC-CURIC N,WINTER S,KRAJISNIK D,et al.Stability evaluation of temoporfin-loaded liposomal gels for topical application[J].J Liposome Res,2010,20(1):38-48.
    [2] SHEN C C,SYU W J,LI S Y,et al.Antimicrobial activities of naphthazarins from Arnebia euchroma[J].J Nat Prod,2002,65(12):1857-1862.
    [3] 帅冬华.紫草中化学成分及药理作用的研究进展[J].中外医疗,2009,28(22):103-104.
    [4] 艾庆波,刘玉璇,国大亮.中药紫草的研究进展[J].齐鲁药事,2010,29(10):609-611.
    [5] 严松柏,谈献和,胡玉涛.紫草的研究进展[J].时珍国医国药,2003,14(2):103-105.
    [6] 国家药典委员会.中华人民共和国药典2015版(一部)[S].北京:中国医药科技出版社,2015:1587.
    [7] 徐颖,王敏伟,中谷一泰.β-羟基异戊酰基紫草素对高表达酪氨酸激酶肿瘤细胞系的生长抑制作用[J].沈阳药科大学学报,2003,20(3):203-206.
    [8] 汤俊.《中国药典》含吡咯里西啶生物碱的中药品种与用药安全[J].药学学报,2011,46(7):762-772.
    [9] XIONG A,LI Y,YANG L,et al.Simultaneous determination of senecionine,adonifoline and their metabolites in rat serum by UPLC-ESIMS and its application in pharmacokinetic studies[J].J Pharm Biomed Anal,2009,50(5):1070-1074.
    [10] 李蔚仑,李军生,黄国霞,等.乙酞紫草素的潜在毒性机理研究及毒性评价[J].食品工业,2015,36(5):174-178.
    [11] LI H,CHEN Y,DENG Y,et al.Effects of surface charge of low molecular weight heparin-modified cationic liposomes on drug efficacy and toxicity[J].Drug Dev Ind Pharm,2017,43(7):1163-1172.
    [12] 岳永阳.脂质体在中药制剂中的研究及应用进展[J].首都食品与医药,2015,22(12):100-102.
    [13] 周彤.复方紫草凝胶剂的制备与研究[D].天津:天津工业大学,2017.
    [14] 咎坷,苏蕊,滕爱君,等.新疆紫草HPLC特征图谱和紫草类药材6种萘醌类成分含量测定[J].药物分析杂志,2016,36(9):1526-1535.
  • 加载中
通讯作者: 陈斌, bchen63@163.com
  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

  1. 本站搜索
  2. 百度学术搜索
  3. 万方数据库搜索
  4. CNKI搜索
Get Citation
PDF
XML

Article Metrics

Article views(3162) PDF downloads(365) Cited by()

Related
Proportional views

Preparation and properties of alkalized shikonin liposome

doi: 10.3969/j.issn.1006-0111.2019.01.016
  • 1. Shanghai Jingan Institute for Food and Drug Control, Shanghai 200435, China
  • 2. Tongren Hospital Affiliated to School of Medicine, Shanghai Jiaotong University, Shanghai 200050, China
  • Received Date: 2018-07-22
  • Rev Recd Date: 2018-11-12

Abstract: Objective To study the preparation and properties of alkalized shikonin liposome. Methods Alkalized shikonin was purified from extracts of radix lithospermi with an alkali solution and acid formulation, and then the alkalized shikonin liposome was prepared by ethanol injection.The morphology, particle size and Zeta potential were determined, and the encapsulation efficiency and the in vitro release property were investigated.The content of L-shikonin was also measured by High Performance Liquid Chromatography. Results Alkalized shikonin liposome presented even sphere and normal distribution with particle size of 104.2 nm.The Zeta potential was-14.8 mV.L-shikonin was linear in the range of 5-50 mg/L with the correlation coefficient 0.999 9.The encapsulation efficiency was 43.67%.The final release rate was 65.82%. Conclusion Alkalized shikonin liposome was prepared successfully with good entrapment efficiency and in vitro release property.

SHI Lei, YE Jun, SONG Lei. Preparation and properties of alkalized shikonin liposome[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(1): 69-73. doi: 10.3969/j.issn.1006-0111.2019.01.016
Citation: SHI Lei, YE Jun, SONG Lei. Preparation and properties of alkalized shikonin liposome[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(1): 69-73. doi: 10.3969/j.issn.1006-0111.2019.01.016
shu

    HTML

Reference (14)

Catalog

    版权所有：《药学实践与服务》编辑委员会

    Supervisor & Sponsors: Address: No 325 Guohe Road, ShanghaiPost Code: 200433

    Tel: （021）81871324,81871397 E-mail: yxsjzzs@163.com

    网站备案号 沪ICP备05003363号-1

    Supported by: Beijing Renhe Information Technology Co., Ltd.  

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return