2019 Vol. 37, No. 2
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2019, 37(2): 97-102.
doi: 10.3969/j.issn.1006-0111.2019.02.001
Abstract:
Obesity is closely relative to the increase in diabetes incidence. Most of the current hypoglycemic medicines,such as insulin and its analogues,insulin secretion enhancers,insulin sensitizers and so on,would lead to weight gain,thus aggravating insul...
Obesity is closely relative to the increase in diabetes incidence. Most of the current hypoglycemic medicines,such as insulin and its analogues,insulin secretion enhancers,insulin sensitizers and so on,would lead to weight gain,thus aggravating insul...
2019, 37(2): 103-108.
doi: 10.3969/j.issn.1006-0111.2019.02.002
Abstract:
The detection methods for the illegal addition of PDE-5 inhibitors in botanical dietary supplements were reviewed in this article. So far,FTIR,NIR,and TLC-SERS methods were commonly adopted to rapid detection,and confirmed detection by HPLC,LC-MS met...
The detection methods for the illegal addition of PDE-5 inhibitors in botanical dietary supplements were reviewed in this article. So far,FTIR,NIR,and TLC-SERS methods were commonly adopted to rapid detection,and confirmed detection by HPLC,LC-MS met...
2019, 37(2): 109-114,155.
doi: 10.3969/j.issn.1006-0111.2019.02.003
Abstract:
Osteoporosis (OP) is a systemic osteopathy with low bone mineral density and bone quality.It seriously endangered human physical and mental health due to its destructive and widespread characteristics.In clinic,drugs for OP,such as bisphosphonates an...
Osteoporosis (OP) is a systemic osteopathy with low bone mineral density and bone quality.It seriously endangered human physical and mental health due to its destructive and widespread characteristics.In clinic,drugs for OP,such as bisphosphonates an...
2019, 37(2): 115-120,145.
doi: 10.3969/j.issn.1006-0111.2019.02.004
Abstract:
Objective To study the effects of positive electret 5-FU patch on the expression of type Ⅰ,Ⅲ collagens and TGF-β in rabbit ear scar tissue. Methods The positive electret 5-fluorouracil (5-FU) patches with surface potential of+5 kV were made by atta...
Objective To study the effects of positive electret 5-FU patch on the expression of type Ⅰ,Ⅲ collagens and TGF-β in rabbit ear scar tissue. Methods The positive electret 5-fluorouracil (5-FU) patches with surface potential of+5 kV were made by atta...
2019, 37(2): 121-125.
doi: 10.3969/j.issn.1006-0111.2019.02.005
Abstract:
Objective To explore the impact of chronic unpredicted mild stress (CUMS)induced depression on mRNA and protein expression of liver organic anion transporting polypeptides (Oatps) in rats. Methods Twenty-four male SD rats were divided into depressi...
Objective To explore the impact of chronic unpredicted mild stress (CUMS)induced depression on mRNA and protein expression of liver organic anion transporting polypeptides (Oatps) in rats. Methods Twenty-four male SD rats were divided into depressi...
2019, 37(2): 126-134.
doi: 10.3969/j.issn.1006-0111.2019.02.006
Abstract:
Objective To explore the intrinsic mechanism of kidney injury due to calcium oxalate crystal by the study on the changes of metabolites in the urine of mice. Method UPLC-Q-TOF/MS-based metabolomics method was used to determine the changes of endoge...
Objective To explore the intrinsic mechanism of kidney injury due to calcium oxalate crystal by the study on the changes of metabolites in the urine of mice. Method UPLC-Q-TOF/MS-based metabolomics method was used to determine the changes of endoge...
2019, 37(2): 135-140,150.
doi: 10.3969/j.issn.1006-0111.2019.02.007
Abstract:
Objective To develop a multi-purpose protective cream with waterproof,sunscreen and jellyfish sting protection and optimize the formulation to provide good water resistance,high SPF,suitable viscosity and good stability. Methods The mass fraction o...
Objective To develop a multi-purpose protective cream with waterproof,sunscreen and jellyfish sting protection and optimize the formulation to provide good water resistance,high SPF,suitable viscosity and good stability. Methods The mass fraction o...
2019, 37(2): 141-145.
doi: 10.3969/j.issn.1006-0111.2019.02.008
Abstract:
Objective To explore the possible mechanism of synergistic effect of synbiotic preparations by regulating intestinal flora to achieve antihypertensive effect by the metabolomics-related techniques. Methods Fourteen spontaneously hypertensive rats w...
Objective To explore the possible mechanism of synergistic effect of synbiotic preparations by regulating intestinal flora to achieve antihypertensive effect by the metabolomics-related techniques. Methods Fourteen spontaneously hypertensive rats w...
2019, 37(2): 146-150.
doi: 10.3969/j.issn.1006-0111.2019.02.009
Abstract:
Objective To study the protective effect and mechanism of dichloroacetate (DCA) on BV2 microglia in oxygen glucose deprivation (OGD) injury model. Methods BV2 cells were divided into 3 groups:CON group,OGD group and DCA intervention group.The injur...
Objective To study the protective effect and mechanism of dichloroacetate (DCA) on BV2 microglia in oxygen glucose deprivation (OGD) injury model. Methods BV2 cells were divided into 3 groups:CON group,OGD group and DCA intervention group.The injur...
2019, 37(2): 151-155.
doi: 10.3969/j.issn.1006-0111.2019.02.010
Abstract:
Objective To investigate the active secondary metabolites of coral derived fungi Aspergillus flavipes. Methods Compounds were isolated and purified by means of various chromatographic techniques,including Silica gel column chromatography,Sephadex L...
Objective To investigate the active secondary metabolites of coral derived fungi Aspergillus flavipes. Methods Compounds were isolated and purified by means of various chromatographic techniques,including Silica gel column chromatography,Sephadex L...
2019, 37(2): 156-161,169.
doi: 10.3969/j.issn.1006-0111.2019.02.011
Abstract:
Objective To develop a rapid method to characterize the inhibitory effect of amphotericin B(AMB) against Candida albicans by dynamic surface enhanced Raman spectroscopy(D-SERS). Methods D-SERS were applied to analyze the effect of AMB on the Raman ...
Objective To develop a rapid method to characterize the inhibitory effect of amphotericin B(AMB) against Candida albicans by dynamic surface enhanced Raman spectroscopy(D-SERS). Methods D-SERS were applied to analyze the effect of AMB on the Raman ...
2019, 37(2): 162-165.
doi: 10.3969/j.issn.1006-0111.2019.02.012
Abstract:
Objective To establish a HPLC method for the determination of the voriconazole concentration in human plasma,which can be used for voriconazole monitoring clinically. Methods High performance liquid chromatography (HPLC-UV) detection method was use...
Objective To establish a HPLC method for the determination of the voriconazole concentration in human plasma,which can be used for voriconazole monitoring clinically. Methods High performance liquid chromatography (HPLC-UV) detection method was use...
2019, 37(2): 166-169.
doi: 10.3969/j.issn.1006-0111.2019.02.013
Abstract:
Objective To study the preparation process of bromhexine hydrochloride nasal drop,develop the assay method for the main component in the drop and evaluate its transdermal penetration in vitro. Methods The bromhexine hydrochloride was prepared with...
Objective To study the preparation process of bromhexine hydrochloride nasal drop,develop the assay method for the main component in the drop and evaluate its transdermal penetration in vitro. Methods The bromhexine hydrochloride was prepared with...
2019, 37(2): 170-172,187.
doi: 10.3969/j.issn.1006-0111.2019.02.014
Abstract:
Objective To develop a method for the determination of the dissolution of Zhibitai capsules. Methods The chromatographic analysis was carried out on a ZABAX-C18column(250 mm×4.6 mm,5 μm)with methanol-0.05% phosphate solution(60∶40) as mobile phase....
Objective To develop a method for the determination of the dissolution of Zhibitai capsules. Methods The chromatographic analysis was carried out on a ZABAX-C18column(250 mm×4.6 mm,5 μm)with methanol-0.05% phosphate solution(60∶40) as mobile phase....
2019, 37(2): 173-176.
doi: 10.3969/j.issn.1006-0111.2019.02.015
Abstract:
Objective To establish a method for the assay of six active ingredients in Kuhuang injection and study the infusion stability prepared with three different solvents. Methods ①UPLC-MS/MS was used to determine the contents of matrine,dioscin,emodin,r...
Objective To establish a method for the assay of six active ingredients in Kuhuang injection and study the infusion stability prepared with three different solvents. Methods ①UPLC-MS/MS was used to determine the contents of matrine,dioscin,emodin,r...
2019, 37(2): 177-182.
doi: 10.3969/j.issn.1006-0111.2019.02.016
Abstract:
Objective To establish an one step assay method for 10 active components (neochlorogenic acid,chlorogenic acid,cryptochlorogenic acid,caffeic acid,forsythoside B,forsythoside A,baicalin,wogonoside,baicalein,wogonin)in compound Jinyinhua granules. Me...
Objective To establish an one step assay method for 10 active components (neochlorogenic acid,chlorogenic acid,cryptochlorogenic acid,caffeic acid,forsythoside B,forsythoside A,baicalin,wogonoside,baicalein,wogonin)in compound Jinyinhua granules. Me...
2019, 37(2): 183-187.
doi: 10.3969/j.issn.1006-0111.2019.02.017
Abstract:
Objective To participate in the clinical treatment and pharmaceutical care for a patient with subacute stent thrombosis complicated with liver-function abnormalities after percutaneous coronary intervention(PCI)and to explore the role of clinical ph...
Objective To participate in the clinical treatment and pharmaceutical care for a patient with subacute stent thrombosis complicated with liver-function abnormalities after percutaneous coronary intervention(PCI)and to explore the role of clinical ph...
2019, 37(2): 188-192.
doi: 10.3969/j.issn.1006-0111.2019.02.018
Abstract:
Objective To systematically evaluate the adverse drug reactions(ADR) and the Adverse drug events(ADE) of children using different aminopyrine in order to know the distribution of ADR and ADE, including the organ distribution, severity distribution, ...
Objective To systematically evaluate the adverse drug reactions(ADR) and the Adverse drug events(ADE) of children using different aminopyrine in order to know the distribution of ADR and ADE, including the organ distribution, severity distribution, ...
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