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2018 Vol. 36, No. 6

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Study on animal models and mechanisms of systemic lupus erythematosus
WU Lan, CAI Tongkai, ZHANG Lichao, JIANG Yuanying, CAO Yongbing
2018, 36(6): 481-483,492. doi: 10.3969/j.issn.1006-0111.2018.06.001
Abstract(5803) PDF (392KB)(635)
Abstract:
Objective Systemic lupus erythematosus (SLE) models were mainly divided into spontaneous and induced models. Through the literature,spontaneous and induced SLE models and their main characteristics were reviewed, which provided references for the re...
Research progress on matrix formulations of Traditional Chinese Medicine cataplasm
MENG Gefei, CHAI Rongrong, DING Jianing, ZHU Congcong, ZHU Quangang
2018, 36(6): 484-487,498. doi: 10.3969/j.issn.1006-0111.2018.06.002
Abstract(5175) PDF (393KB)(513)
Abstract:
Traditional Chinese Medicine cataplasm has remarkable clinical effects with the advantages of no liver first-pass and easy to apply. It is one of the most promising drug delivery systems following oral and injective administration. In this paper, the...
Research progress on the effect of UGT1A1 gene polymorphisms on drug metabolism and clinical efficacy
ZHANG Zhe, CAI Weimin
2018, 36(6): 488-492. doi: 10.3969/j.issn.1006-0111.2018.06.003
Abstract(4206) PDF (404KB)(1469)
Abstract:
UGT1A1 is an important gene in the process of drug metabolism. With the development of pharmacogenomics,which have been found that the UGT1A1 gene polymorphisms is relevant to the level of metabolism, affect the occurrence,development and treatment o...
Pharmacodynamic study of total celosins on anti-hyperlipidemia
WU Wendan, LIANG Lin, TANG Ying, NI Hailai, GUO Meili
2018, 36(6): 493-498. doi: 10.3969/j.issn.1006-0111.2018.06.004
Abstract:
Objective To study the effect of total saponin (CES) on lipid metabolism in hyperlipidemic animals. Methods Golden hamster and rabbit hyperlipidemia animal models were established for this study.Both hyperlipidemia models were achieved by feeding ...
Oxidative stress induced by homocysteine via activating JNK signaling pathway in vascular smooth muscle cells
SHEN Qirui, LI Yonghua, ZHANG Wenjie, WANG Pei
2018, 36(6): 499-502,511. doi: 10.3969/j.issn.1006-0111.2018.06.005
Abstract:
Objective To investigate the influence and the underlying mechanisms of homocysteine on oxidative stress production in vascular smooth muscle cells (VSMC). Methods A10 cell line (a kind of VSMC) was cultured in vitro. Three different concentrations...
Establishment of HPLC fingerprint for Wenjing Tang
CHAI Ruiping, LU Juan, ZHAO Ying, WANG Xiaojing, LÜ Xinkai, CHEN Xi
2018, 36(6): 503-506. doi: 10.3969/j.issn.1006-0111.2018.06.006
Abstract(3823) PDF (1790KB)(1029)
Abstract:
Objective To establish chromatographic fingerprint for Wenjing Tang by HPLC-DAD. Methods The fingerprint was determined by Waters Xselect HSS T3 column (4.6 mm×250 mm,5μm) with acetoniteile-0.1% formic acid solution as mobile phase for gradient el...
Pharmacodynamics studies on Wentong Gao prepared with new process
HUANG Xiaobing, WU Xueru, WU Han, XIE Huamin
2018, 36(6): 507-511. doi: 10.3969/j.issn.1006-0111.2018.06.007
Abstract(5404) PDF (339KB)(380)
Abstract:
Objective To study the analgesic, anti-inflammatory, reducing swelling and removing blood stasis effects of Wentong Gao prepared with the new process. Methods Acetic acid writhing test and formaldehyde induced mouse foot pain test were used to obs...
Simultaneous determination of 5 B-vitamins in compound trivitamin and calcium pantothenate syrup by UHILIC-MS/MS
REN Qiangqiang, ZHAO Youqin, XU Wen, HUANG Mingqing, YE Shuiguo, SHI Zhenxiang
2018, 36(6): 512-517,528. doi: 10.3969/j.issn.1006-0111.2018.06.008
Abstract:
Objective To establish a ultra hydrophilic interaction chromatography-tandem mass spectrometry (UHILIC-MS/MS) for the simultaneous determination of 5 B-vitamins including thiamine, riboflavin, pyridoxine, nicotinamide and calcium pantothenate in Com...
The rational use of antiplatelet drugs guided by CYP2C19 genotyping in patients with coronary heart disease after PCI
ZHANG Hongnan, WANG Qiang, ZHU Xiaohong, LANG Yiyong
2018, 36(6): 518-521. doi: 10.3969/j.issn.1006-0111.2018.06.009
Abstract(3077) PDF (433KB)(323)
Abstract:
Objective To explore the rational use of antiplatelet agents in patients with coronary heart disease after PCI guided by CYP2C19 genotyping. Methods Using the hospital management information system, 2 836 patients with coronary heart disease hospit...
Determination of camphor and menthol in compound camphor liniment by GC and evaluation of uncertainty
NI Xiaoxia, LIU Xiaoling, YE Caifa, WANG Qingfen
2018, 36(6): 522-528. doi: 10.3969/j.issn.1006-0111.2018.06.010
Abstract(3695) PDF (596KB)(387)
Abstract:
Objective To establish a gas chromatography (GC) method to determine the contents of camphor and menthol in compound camphor liniment and to evaluate the uncertainty. Methods Thermo TG-WAXMS (30.0 m×0.25 mm, 0.5 μm) and FID were used with naphtali...
Protective effect of total sesquiterpene lactone from Achillea sibirca on rheumatoid arthritis rats
WANG Jian, QIU Yan, LI Keran, ZHU Wenjun, DONG Yafen, LIU Helong
2018, 36(6): 529-532. doi: 10.3969/j.issn.1006-0111.2018.06.011
Abstract(3331) PDF (431KB)(399)
Abstract:
Objective To investigate the anti-inflammatory effect and mechanism of total sesquiterpene lactone from Achillea sibirca on rheumatoid arthritis rats. Methods An animal model of rheumatoid arthritis was established by the intradermal injection of ...
Regulating effect of Xuefuzhuyu capsule on clopidogrel resistance in patients with severe blood stasis syndrome after PCI operation
HUANG Jin, LI Luyi, QI Weigang, HUANG Ying, ZENG Ying, TANG Fan
2018, 36(6): 533-535,546. doi: 10.3969/j.issn.1006-0111.2018.06.012
Abstract(3384) PDF (877KB)(382)
Abstract:
Objective To observe and evaluate the regulating effect of Xuefuzhuyu capsule combined with clopidogrel on clopidogrel resistance. Methods After PCI operation, 80 patients with clopidogrel resistance were randomly divided into three different trea...
Empirical research on the affordability of the antihypertensive drugs in the basic drug list from Qingpu District
SHEN Yi, WAN Qian, XIE Ning, XU Qing
2018, 36(6): 536-540. doi: 10.3969/j.issn.1006-0111.2018.06.013
Abstract(3138) PDF (688KB)(296)
Abstract:
Objective To evaluate the affordability of oral antihypertensive drugs in Qingpu District within the basic medication system and provide a substantial evidence for rationalizing the price of essential drugs to treat chronic diseases in communities. ...
Seven kinds of new oral anticoagulants for prevention of venous thromboembolism after total hip or knee arthroplasty: a net Meta-analysis
YANG Jie, WEN Hua, MA Bing, SUN Jing
2018, 36(6): 541-546. doi: 10.3969/j.issn.1006-0111.2018.06.014
Abstract:
Objective To assess the efficacy of seven kinds of new oral anticoagulants in prevention of venous thromboembolism in patients after total hip or knee replacement by a network Meta-analysis. Methods Randomized clinical trials in databases of CBM,Co...
Constipation alleviation and the efficacy improvement of levodopa and benserazide in Parkinson patients with early intestinal flora intervention
XU Ling, ZHAO Yan, MAO Ling, ZHANG Xihong
2018, 36(6): 547-550. doi: 10.3969/j.issn.1006-0111.2018.06.015
Abstract(4090) PDF (471KB)(275)
Abstract:
Objective To investigate the effect of early intestinal flora intervention on the symptoms and the efficacy of Levodopa and Benserazide in Parkinson's disease (PD), provide a reference for clinical treatment. Methods 114 patients diagnosed as PD f...
Optimization of assay method for loganin in Gandi capsules
WEI Xin, XU Renjie, TANG Ying, YAO Huan, XU Ajing, ZHANG Jian
2018, 36(6): 551-553. doi: 10.3969/j.issn.1006-0111.2018.06.016
Abstract(3719) PDF (678KB)(372)
Abstract:
Objective To establish a HPLC method for the assay of loganin in Gandi capsules. Methods The Waters Symmtry column C18 (4.6 mm×150 mm, 5 μm) was used with acetonitrile-water (13:87) as mobile phase. The flow rate was 1.0 ml/min and the detection w...
Clinical pharmacist bedside education practice and patient compliance evaluation
FENG Yuluo, WANG Yawei, CHU Yanqi, YAN Suying
2018, 36(6): 554-556,560. doi: 10.3969/j.issn.1006-0111.2018.06.017
Abstract(3510) PDF (735KB)(572)
Abstract:
Objective To evaluate the effect of clinical pharmacist's involvement in medication education and patients' compliance in the elderly patients with chronic diseases before and after the bedside education by clinical pharmacists. Methods The educat...
Analysis on rational application of esomeprazole for injection in hepatobiliary perioperative period
QIAN Xian, CHENG Dan, CHEN Anni, ZHANG Guoqing, ZHAN Qi
2018, 36(6): 557-560. doi: 10.3969/j.issn.1006-0111.2018.06.018
Abstract(3961) PDF (658KB)(587)
Abstract:
Objective To investigate the rationality of esomeprazole for injection in hepatobiliary perioperative period of Eastern Hepatobiliary hospital (hereinafter referred to as our hospital), and to provide reference for the rational drug use in hepatobil...
The experience of educating the public in proper use of medications by hospital pharmacists in Taiwan
CHEN Weili, LEE Chiahui, LIN Chioumaan, HUANG Zhiyun, CHEN Chiayang, GU Yali
2018, 36(6): 561-563. doi: 10.3969/j.issn.1006-0111.2018.06.019
Abstract(3031) PDF (483KB)(794)
Abstract:
In order to promote the knowledge of proper medication use and enhance the core competence of medication safety, the pharmacists from one medical center in Taiwan established "the proper medication use education and resource center" to ensure the the...
Establishment and empirical study of drug price index based on Hedonic model
LI Jian, SHU Lixin, LIU Xijun
2018, 36(6): 564-568. doi: 10.3969/j.issn.1006-0111.2018.06.020
Abstract(3641) PDF (636KB)(432)
Abstract:
Objective To establish the drug price index based on Hedonic model and conduct empirical analysis. Methods From the monitoring data management center for clinical application of antimicrobial agents of CPLA, the official website of the former Chin...
Construction and application of the rational drug use of single-disease index in 16 hospitals
ZHANG Hualin, SHU Lixin
2018, 36(6): 569-572,576. doi: 10.3969/j.issn.1006-0111.2018.06.021
Abstract(3545) PDF (767KB)(363)
Abstract:
Objective The research group tried to set up the rational drug use inpatients index system to compare the differences between different crowds so as to evaluate the influence for Medical intervention policy to the level of the rational drug use. Me...
Effects of community pharmacy intervention on drug compliance for hypertension patients
YE Tengfei, CHENG Tao, SONG Ping, BIAN Xiaolan
2018, 36(6): 573-576. doi: 10.3969/j.issn.1006-0111.2018.06.022
Abstract(3815) PDF (490KB)(898)
Abstract:
To explore the impact of community pharmacy intervention on drug compliance for hypertension patients, provide safe and effective drug use guidance for patients and give suggestions for clinical pharmacists in second-grade hospitals how to improve ph...