2018 Vol. 36, No. 5
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2018, 36(5): 385-388,456.
doi: 10.3969/j.issn.1006-0111.2018.05.001
Abstract:
The protein phosphatase 2C family (PP2C), belonging the protein phosphatases, is a kind of importantly specific serine/threonine dephosphatase. Recent studies show that PP2C control a lot of critical cellular functions:proliferation, cell cycle arres...
The protein phosphatase 2C family (PP2C), belonging the protein phosphatases, is a kind of importantly specific serine/threonine dephosphatase. Recent studies show that PP2C control a lot of critical cellular functions:proliferation, cell cycle arres...
2018, 36(5): 389-391,398.
doi: 10.3969/j.issn.1006-0111.2018.05.002
Abstract:
Cortex phellodendri is a traditional Chinese medicine with the effects of clearing away heat, purging fire and dampness, detoxification and detumescence. Its main chemical constituents are flavonoids and alkaloids, which have many pharmacological eff...
Cortex phellodendri is a traditional Chinese medicine with the effects of clearing away heat, purging fire and dampness, detoxification and detumescence. Its main chemical constituents are flavonoids and alkaloids, which have many pharmacological eff...
2018, 36(5): 392-398.
doi: 10.3969/j.issn.1006-0111.2018.05.003
Abstract:
This article reviews the research on the effects of symbiotic fungi on plant drought resistance. Symbiotic fungi are widely distributed,which can form symbionts with plants. Studies have shown that some endophyte and symbiotic fungi can enhance plant...
This article reviews the research on the effects of symbiotic fungi on plant drought resistance. Symbiotic fungi are widely distributed,which can form symbionts with plants. Studies have shown that some endophyte and symbiotic fungi can enhance plant...
2018, 36(5): 399-402,421.
doi: 10.3969/j.issn.1006-0111.2018.05.004
Abstract:
Objective To investigate the potential effect of marine sponge-derived smenospongine (Sme) on apoptosis in breast cancer MCF7 cells. Methods The CCK-8 method was used to detect growth-inhibitory effect of Sme against MCF7 cells. Flow cytometry was...
Objective To investigate the potential effect of marine sponge-derived smenospongine (Sme) on apoptosis in breast cancer MCF7 cells. Methods The CCK-8 method was used to detect growth-inhibitory effect of Sme against MCF7 cells. Flow cytometry was...
2018, 36(5): 403-408,416.
doi: 10.3969/j.issn.1006-0111.2018.05.005
Abstract:
Objective To study the mechanism of Ganlibao capsule on liver protection by network pharmacology. Methods The active ingredients of Ganlibao capsule were selected and the targets of these ingredients were predicted by the reverse pharmacophore met...
Objective To study the mechanism of Ganlibao capsule on liver protection by network pharmacology. Methods The active ingredients of Ganlibao capsule were selected and the targets of these ingredients were predicted by the reverse pharmacophore met...
2018, 36(5): 409-416.
doi: 10.3969/j.issn.1006-0111.2018.05.006
Abstract:
Objective To explore the effects and mechanisms of probiotics on nonalcoholic fatty liver disease related intestinal epithelial cells, Kupffer cells and liver parenchymal cells. Methods Human intestinal epithelial cells Caco-2, rat Kupffer cells a...
Objective To explore the effects and mechanisms of probiotics on nonalcoholic fatty liver disease related intestinal epithelial cells, Kupffer cells and liver parenchymal cells. Methods Human intestinal epithelial cells Caco-2, rat Kupffer cells a...
2018, 36(5): 417-421.
doi: 10.3969/j.issn.1006-0111.2018.05.007
Abstract:
Objective To synthesize position 1 substituted sinomenine derivatives and study their anti-inflammatory activity in vitro. Methods A series of substituted sinomenine derivatives were prepared by bromination of sinomenine and Suzuki coupling reacti...
Objective To synthesize position 1 substituted sinomenine derivatives and study their anti-inflammatory activity in vitro. Methods A series of substituted sinomenine derivatives were prepared by bromination of sinomenine and Suzuki coupling reacti...
Establishment of the characteristic index system of drug price based on the main information content
2018, 36(5): 422-425.
doi: 10.3969/j.issn.1006-0111.2018.05.008
Abstract:
Objective To establish the characteristic index system of drug price based on the factor analysis method with the main information content. Methods The characteristic index system of drug price was preliminarily established, and the importance and...
Objective To establish the characteristic index system of drug price based on the factor analysis method with the main information content. Methods The characteristic index system of drug price was preliminarily established, and the importance and...
2018, 36(5): 426-429,467.
doi: 10.3969/j.issn.1006-0111.2018.05.009
Abstract:
Objective To improve the quality standards of Hypericum ascyron. Methods Hypericum ascyron was identified by microscopic observation and TLC method.The moisture, total ash,acid-insoluble ash and alcohol soluble extract were assayed following the p...
Objective To improve the quality standards of Hypericum ascyron. Methods Hypericum ascyron was identified by microscopic observation and TLC method.The moisture, total ash,acid-insoluble ash and alcohol soluble extract were assayed following the p...
2018, 36(5): 430-432.
doi: 10.3969/j.issn.1006-0111.2018.05.010
Abstract:
Objective To establish quality standard for Fufang Huzhangding. Methods Qualitative identification of Polygonum cuspidatum,Apis mellifeta and Borneolum in Fufang Huzhangding by thin layer chromatography;The mobile phase was acetonitrile-water(23:7...
Objective To establish quality standard for Fufang Huzhangding. Methods Qualitative identification of Polygonum cuspidatum,Apis mellifeta and Borneolum in Fufang Huzhangding by thin layer chromatography;The mobile phase was acetonitrile-water(23:7...
2018, 36(5): 433-437.
doi: 10.3969/j.issn.1006-0111.2018.05.011
Abstract:
Objective Overweight might be a risk factor of acute mountain sickness (AMS) but its efficacy on developing AMS remained controversial. To study the role of overweight in AMS by a Meta-analysis. Methods A comprehensive literature search (last upda...
Objective Overweight might be a risk factor of acute mountain sickness (AMS) but its efficacy on developing AMS remained controversial. To study the role of overweight in AMS by a Meta-analysis. Methods A comprehensive literature search (last upda...
2018, 36(5): 438-442,452.
doi: 10.3969/j.issn.1006-0111.2018.05.012
Abstract:
Objective To study the therapeutic effects of Yangwei granules on experimental gastric ulcer. Methods Four animal models of experimental gastric ulcer included water immersion stress and acetic acid induced gastric ulcer in rats, indomethacin and ...
Objective To study the therapeutic effects of Yangwei granules on experimental gastric ulcer. Methods Four animal models of experimental gastric ulcer included water immersion stress and acetic acid induced gastric ulcer in rats, indomethacin and ...
2018, 36(5): 443-445,460.
doi: 10.3969/j.issn.1006-0111.2018.05.013
Abstract:
Objective To establish a sensitive method for determination of concentration of lamotrigine (LTG) in rat plasma and to study the pharmacokinetics by LC-MS/MS. Methods 12 rats were divided evenly into model group and shame-operated group. LTG was g...
Objective To establish a sensitive method for determination of concentration of lamotrigine (LTG) in rat plasma and to study the pharmacokinetics by LC-MS/MS. Methods 12 rats were divided evenly into model group and shame-operated group. LTG was g...
2018, 36(5): 446-449.
doi: 10.3969/j.issn.1006-0111.2018.05.014
Abstract:
Objective To establish a GC-MS method for residue detection of 4-Dimethylaminopyridine (DMAP) and Dicyclohexyl Carbodiimide (DCC) in docetaxel. Methods The separation was performed on an Agilent DB-5msUI capillary column (30 m×0.25 mm, 0.25 μm) wi...
Objective To establish a GC-MS method for residue detection of 4-Dimethylaminopyridine (DMAP) and Dicyclohexyl Carbodiimide (DCC) in docetaxel. Methods The separation was performed on an Agilent DB-5msUI capillary column (30 m×0.25 mm, 0.25 μm) wi...
2018, 36(5): 450-452.
doi: 10.3969/j.issn.1006-0111.2018.05.015
Abstract:
Objective To investigate the relationship between procalcitonin (PCT) levels and bacteria in patients with bloodstream infection who were already administered antimicrobial therapy. Methods Retrospective collected the patients with monomicrobial b...
Objective To investigate the relationship between procalcitonin (PCT) levels and bacteria in patients with bloodstream infection who were already administered antimicrobial therapy. Methods Retrospective collected the patients with monomicrobial b...
2018, 36(5): 453-456.
doi: 10.3969/j.issn.1006-0111.2018.05.016
Abstract:
Objective To observe the influence of shikonin on pathological changes of liver tissue, expression of TGF-β1 in liver fibrosis in rats and to explore the possible mechanism of shikonin on rats' liver fibrosis. Methods 40 SD rats were randomly divi...
Objective To observe the influence of shikonin on pathological changes of liver tissue, expression of TGF-β1 in liver fibrosis in rats and to explore the possible mechanism of shikonin on rats' liver fibrosis. Methods 40 SD rats were randomly divi...
2018, 36(5): 457-460.
doi: 10.3969/j.issn.1006-0111.2018.05.017
Abstract:
Objective To investigate the effect of memantine hydrochloride on improving neurocognitive function in patients with ischemic stroke. Methods Patients with hemorrhagic stroke who were treated in the officer consultation department of General Hospi...
Objective To investigate the effect of memantine hydrochloride on improving neurocognitive function in patients with ischemic stroke. Methods Patients with hemorrhagic stroke who were treated in the officer consultation department of General Hospi...
2018, 36(5): 461-463.
doi: 10.3969/j.issn.1006-0111.2018.05.018
Abstract:
Objective To explore the way for clinical pharmacists to involve in anti-inflammatory treatment of pancreatitis. Methods Pharmaceutical recommendations were put forward through the literature and related guideline review and pharmaceutical care wa...
Objective To explore the way for clinical pharmacists to involve in anti-inflammatory treatment of pancreatitis. Methods Pharmaceutical recommendations were put forward through the literature and related guideline review and pharmaceutical care wa...
2018, 36(5): 464-467.
doi: 10.3969/j.issn.1006-0111.2018.05.019
Abstract:
Objective To explore how clinical pharmacists participating in medication regimen design and carrying out pharmaceutical care. Methods The clinical pharmacist participated in the therapy for a patient with acute-to-chronic liver failure associated...
Objective To explore how clinical pharmacists participating in medication regimen design and carrying out pharmaceutical care. Methods The clinical pharmacist participated in the therapy for a patient with acute-to-chronic liver failure associated...
2018, 36(5): 468-470.
doi: 10.3969/j.issn.1006-0111.2018.05.020
Abstract:
Objective To investigate the efficacy and safety of combination therapy with sitagliptin and premixed insulin in the treatment of brittle diabetes with hyperlipidemia. Methods 158 patients treated at endocrinology clinic in our hospital for brittl...
Objective To investigate the efficacy and safety of combination therapy with sitagliptin and premixed insulin in the treatment of brittle diabetes with hyperlipidemia. Methods 158 patients treated at endocrinology clinic in our hospital for brittl...
2018, 36(5): 471-474.
doi: 10.3969/j.issn.1006-0111.2018.05.021
Abstract:
Objective To provide the basic foundation of pharmaceutical care(PC) for the disabled by community pharmacist (CP) and to ensure the safety of drug use for the disabled by investigating and analyzing the patient's needs for community pharmaceutical ...
Objective To provide the basic foundation of pharmaceutical care(PC) for the disabled by community pharmacist (CP) and to ensure the safety of drug use for the disabled by investigating and analyzing the patient's needs for community pharmaceutical ...
2018, 36(5): 475-478.
doi: 10.3969/j.issn.1006-0111.2018.05.022
Abstract:
Objective To investigate the application of Lipo-PEG1 injection in our hospital, analyze the rationality of its clinical application and evaluate the role of the administrative intervention in promoting the rational drug use in the hospital. Method...
Objective To investigate the application of Lipo-PEG1 injection in our hospital, analyze the rationality of its clinical application and evaluate the role of the administrative intervention in promoting the rational drug use in the hospital. Method...
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