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2014 Vol. 32, No. 6

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Mechanisms of damage and treatments of cerebral ischemia and reperfusion
WU Jinhua, MA Huiping, MENG Ping, JIA Zhengping
2014, 32(6): 401-404,447. doi: 10.3969/j.issn.1006-0111.2014.06.001
Abstract(5166) PDF (508KB)(169)
Abstract:
To summarize the advances in mechanisms of damage and treatments of cerebral ischemia and reperfusion and forecasts future research directions.The existing achievements in literatures were summarized.Cerebral ischemia and reperfusion damage were rela...
The research progress of parathyroid hormone and parathyroid hormone-related peptide in skin disease
BU Xiaolin, BI Xinling, XU Xiaoguang, GAO Zhixiang, LI Hui, GU Jun
2014, 32(6): 405-408. doi: 10.3969/j.issn.1006-0111.2014.06.002
Abstract(4368) PDF (254KB)(116)
Abstract:
Parathyroid hormone/parathyroid hormone-related peptides are polypeptide hormones. They have similar gene structure and same membrane receptor. They play great roles in regulating the calcium and phosphorus metabolism in vivo. PTH/PTHrP and their rec...
Research development of lipid microsphere delivery system
ZHANG Xiuli, MA Yueqin, LI Gang
2014, 32(6): 409-411,459. doi: 10.3969/j.issn.1006-0111.2014.06.003
Abstract(4700) PDF (677KB)(265)
Abstract:
Lipid microsphere drug delivery system is a hot issue in pharmceutics studies. In this paper, the mechanism, preparation method and the key influence factors of lipid microsphere drug delivery system were reviewed respectively. Some new discovery and...
Progress on the hepatotoxicity of lipid-lowering drugs and its prevention strategies
XU Yancheng, FANG Yijie, YAN Lan, JIANG Yuanying, CAO Yongbing
2014, 32(6): 412-415,464. doi: 10.3969/j.issn.1006-0111.2014.06.004
Abstract(3318) PDF (510KB)(240)
Abstract:
Hepatotoxicity is one of the most common adverse reactions during anti-hyperlipidemia treatment. Mechanisms of anti-hyperlipidemia drug-induced hepatotoxicity are not clear yet, but most of the toxic reactions are dose-related hypersensitivity and co...
Current situation of evaluation and application with alternative dosing regimens for piperacillin sodium-tazobactam sodium
LI Yuanyuan, YU Feng
2014, 32(6): 416-418,452. doi: 10.3969/j.issn.1006-0111.2014.06.005
Abstract(3040) PDF (483KB)(232)
Abstract:
Objective To offer reference to reasonable clinical use of piperacillin sodium sodium-tazobactam sodium. Methods We reviewed pharmacokinetic/ pharmacodynamic studies, clinical trails and implementation of piperacillin sodium-tazobactam sodium alter...
Optimized preparation of DNA-chitosan nanoparticles with high transfection efficency through a central composition design
SHAO Shuai, CUI Guanghua, ZHOU Xu, GAO Zhonggao, HUANG Wei
2014, 32(6): 419-424. doi: 10.3969/j.issn.1006-0111.2014.06.006
Abstract:
Objective This study aimed to optimize the preparation condition of DNA-chitosan nanoparticles with high transfection efficency through a central composition design. Methods The DNA-chitosan nanoparticles were prepared by complex coacervation betwe...
Screening of potential active anti-cancer components of Brucea javanica by SMMC-7721 and Hep-G2 comprehensive two dimensional CMC-monolith chromatography
JI Songgang, DING Xuan, CAO Yan, CHEN Xiaofei, JIA Dan, WANG Dongyao, CHAI Yifeng
2014, 32(6): 425-427,433. doi: 10.3969/j.issn.1006-0111.2014.06.007
Abstract:
Objective To screen potential active anti-cancer components of Brucea javanica. Methods This research has employed comprehensive two dimensional chromatographic technology and cell membrane chromatographic technology simultaneously with mass spectr...
A comparison study of synthesizing methods of thiolated doxorubicin
WU Shan, ZHANG Yeye, GUO Haixia, LIU Junjie, SUN Zhiguo, ZHONG Yanqiang, ZOU Hao
2014, 32(6): 428-433. doi: 10.3969/j.issn.1006-0111.2014.06.008
Abstract:
Objective To investigate the optimal method for synthesizing thiolated doxorubicin. Methods Thiolated doxorubicin was synthesized through two different methods. Doxorubicin was reacted with 2-iminothiolane (2-IT) and S-acetylthioglycolic acid N-hyd...
Protein stability and hemolytic activity of tentacle extract from the jellyfish Cyanea capillata
CHANG Yinlong, XIAO liang, ZHENG Jiemin, WANG Qianqian, ZHANG Liming
2014, 32(6): 434-439. doi: 10.3969/j.issn.1006-0111.2014.06.009
Abstract:
Objective To investigate the influencing factors of the protein stability and hemolytic activity of tentacle extract (TE) from the jellyfish Cyanea capillata. Methods Effects of various factors and treatments on the protein stability and hemolytic...
Effects and mechanism of TG6 on myocardial ischemia and reperfusion injury
CHENG Jingjing, LIU Mouzhi, LI Hongjiao, YAN Lan, JIANG Yuanying, YAN Tianhua
2014, 32(6): 440-443. doi: 10.3969/j.issn.1006-0111.2014.06.010
Abstract(3111) PDF (980KB)(154)
Abstract:
Objective To investigate the protective effects and mechanism of TG6 on myocardial ischemia/reperfusion injury. Methods the protective effects of TG6 on myocardial ischemia/reperfusion was investigated by setting up models of ischemia and reperfusi...
Study on local pharmacokinetics of baicalin gel after transdermal administration in rats by skin microdialysis in vivo
LOU Yuefen, ZHU Quangang, YOU Benming, LI Jie, GU Xiaoyan, ZHANG Ruoxi
2014, 32(6): 444-447. doi: 10.3969/j.issn.1006-0111.2014.06.011
Abstract(3316) PDF (624KB)(342)
Abstract:
Objective To develop a novel skin microdialysis technology in vivo,and to determine the pharmacokinetic of baicalin after transdermal administration in rats. Methods An HPLC-MS/MS method used for the determination of baicalin in skin microdialysis ...
Rapid identification of chemical components in Artemisiae argyi folium by RRLC-TOFMS
LI Ling, Lü Lei, DONG Xin, LV Diya, LOU Ziyang
2014, 32(6): 448-452. doi: 10.3969/j.issn.1006-0111.2014.06.012
Abstract(3371) PDF (768KB)(581)
Abstract:
Objective To identify the chemical components in Artemisiae argyi folium by rapid resolution liquid chromatography-time of flight mass spectrometry (RRLC-TOFMS). Methods The separation was performed on an Agilent Eclipse C18 column (2.1 mmü100 mm,1...
Evaluation of probiotics effectiveness in hospitalized pneumonia children by electronic medical records
SUN Huajun, GU Zhirui, CHE Datian, GAO Chunhui, YU Guangjun
2014, 32(6): 453-455,479. doi: 10.3969/j.issn.1006-0111.2014.06.013
Abstract(3029) PDF (512KB)(307)
Abstract:
Objective To describe the profile of probiotics utilization in hospitalized pneumonia children and evaluate the effectiveness of probiotics in the treatment of pneumonia in hospitalized children combined with antibiotics. Methods Descriptive data a...
Preparation and characterization of chrysin-hydroxypropyl-β-cyclodextrins inclusion compound
ZENG Qian, JI Hui, TANG Huihui, XIE Xueyuan
2014, 32(6): 456-459. doi: 10.3969/j.issn.1006-0111.2014.06.014
Abstract(3114) PDF (946KB)(407)
Abstract:
Objective To prepare the water soluble chrysin-hydroxypropyl-β-cyclodextrins inclusion compound and widen the administration path of chrysin. Methods The cogrinding method had been used to prepare chrysin-hydroxypropyl-β-cyclodextrins inclusion co...
Practice and experience of clinical pharmacists involved in pharmaceutical care of diabetes mellitus complicated with pulmonary infection patients
JU Yufeng, SHI Yu
2014, 32(6): 460-461,468. doi: 10.3969/j.issn.1006-0111.2014.06.015
Abstract(4035) PDF (481KB)(397)
Abstract:
Objective To explore the content and effect of carrying out pharmaceutical care by participating in geriatric diabetes mellitus complicated with pulmonary infection in patients. Methods Pharmacy services elaborated form, content, priorities and res...
Anti-infection treatment and pharmaceutical care for one patient of liver cirrhosis complicated with pleural effusion
CAO Xihong, XUE Peili, ZHANG Lili
2014, 32(6): 462-464. doi: 10.3969/j.issn.1006-0111.2014.06.016
Abstract(3090) PDF (443KB)(114)
Abstract:
Objective To investigate the value of clinical pharmacists in clinical treatment through the practice of clinical pharmacists participating in clinical drug treatment and providing pharmaceutical care to patients. Methods Clinical pharmacists were ...
Analyzation and suggestion of irregular usage of drug prescriptions in clinic
LIU Xia
2014, 32(6): 465-468. doi: 10.3969/j.issn.1006-0111.2014.06.017
Abstract(3552) PDF (511KB)(517)
Abstract:
Objective To offer suggestions for how to administrate irregular usage of drug prescriptions in clinic. Methods The objective reasons and the hidden danger of irregular usage of drug prescriptions were analyzed. The existing international administr...
Application of narcotic analgesic in 29 hospitals of Nanjing from 2010 to 2012
PAN Haiyan, LIU Hui, LING Chunyan, WANG Lujun
2014, 32(6): 469-472. doi: 10.3969/j.issn.1006-0111.2014.06.018
Abstract:
Objective To evaluate the current situation and trend of narcotic analgesics used in 29 hospitals of Nanjing from 2010 to 2012 and provide references for reasonable clinical drug utility. Methods Consumption of narcotic analgesics in 29 hospitals ...
Exploration of clinical pharmacists working in the department of orthopedics
Cai Yan, Zhang Kanghuai, Wu Wenying
2014, 32(6): 473-475. doi: 10.3969/j.issn.1006-0111.2014.06.019
Abstract:
Objective To summarize the experience of clinical pharmacist's work and explore the working method of pharmaceutical care in the department of orthopedics. Methods With the characteristics of the orthopedics department, clinical pharmacists should ...
Personnel training program establishment for higher vocational pharmacy based on professional position
Wang Liwen, LIN Lili, Zou Haojun
2014, 32(6): 476-479. doi: 10.3969/j.issn.1006-0111.2014.06.020
Abstract:
Objective To establish personnel training program for higher vocational pharmacy by investigating occupation duties in pharmacy graduates. Methods The employment of pharmacy graduates from higher vocational school was investigated. The professional...
2014, 32(6): 480-480. doi: 10.3969/j.issn.1006-0111.2014.06.021
Abstract(3620) PDF (412KB)(264)
Abstract: