JI Songgang, DING Xuan, CAO Yan, CHEN Xiaofei, JIA Dan, WANG Dongyao, CHAI Yifeng. Screening of potential active anti-cancer components of Brucea javanica by SMMC-7721 and Hep-G2 comprehensive two dimensional CMC-monolith chromatography[J]. Journal of Pharmaceutical Practice and Service, 2014, 32(6): 425-427,433. doi: 10.3969/j.issn.1006-0111.2014.06.007
| Citation:
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JI Songgang, DING Xuan, CAO Yan, CHEN Xiaofei, JIA Dan, WANG Dongyao, CHAI Yifeng. Screening of potential active anti-cancer components of Brucea javanica by SMMC-7721 and Hep-G2 comprehensive two dimensional CMC-monolith chromatography[J]. Journal of Pharmaceutical Practice and Service, 2014, 32(6): 425-427,433. doi: 10.3969/j.issn.1006-0111.2014.06.007
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Screening of potential active anti-cancer components of Brucea javanica by SMMC-7721 and Hep-G2 comprehensive two dimensional CMC-monolith chromatography
- 1.
Department of Pharmacy, No.401 Hospital of PLA, Qingdao 266071, China
- 2.
School of Pharmacy, Second Military Medical University, Shanghai 200433, China
- Received Date: 2014-09-04
- Rev Recd Date:
2014-10-08
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Abstract
Objective To screen potential active anti-cancer components of Brucea javanica. Methods This research has employed comprehensive two dimensional chromatographic technology and cell membrane chromatographic technology simultaneously with mass spectrometry as detector. Results Adenosine and Bruceine B were found to be potentially anti-cancer active. Conclusion This study has combined the advantages of online, high speed and high throughput for the screen of potential active components of traditional Chinese medicine.
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