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Volume 32 Issue 6
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2014  >  32(6): 448-452

ZHAO Jing, CAO Hong, XING Jun-bo. The fingerprint analysis on Chuanshentong injection by HPLC[J]. Journal of Pharmaceutical Practice and Service, 2013, 31(2): 137-139. doi: 10.3969/j.issn.1006-0111.2013.02.016
Citation: LI Ling, Lü Lei, DONG Xin, LV Diya, LOU Ziyang. Rapid identification of chemical components in Artemisiae argyi folium by RRLC-TOFMS[J]. Journal of Pharmaceutical Practice and Service, 2014, 32(6): 448-452. doi: 10.3969/j.issn.1006-0111.2014.06.012
shu

Rapid identification of chemical components in Artemisiae argyi folium by RRLC-TOFMS

doi: 10.3969/j.issn.1006-0111.2014.06.012
  • 1.

    Pharmaceutical Analysis Center, School of Pharmacy, Second Military Medical University, Shanghai 200433, China

  • 2.

    Department of Pharmacy, Eastern Hepatobiliary Surgery Hospital affiliated to Second Military Medical University, Shanghai 200438, China

  • Received Date: 2013-06-09
  • Rev Recd Date: 2013-11-13
  • Objective To identify the chemical components in Artemisiae argyi folium by rapid resolution liquid chromatography-time of flight mass spectrometry (RRLC-TOFMS). Methods The separation was performed on an Agilent Eclipse C18 column (2.1 mmü100 mm,1.8 μm ). The mobile phase consisted of acetonitrile (A) and 0.1% formic acid (B) were in gradient elution.The flowing rate was 0.35 ml/min, the injection volume was 1 μl and the temperature of column was 40℃. Time of flight mass spectrometer (TOFMS) with electro spray ion source (ESI) was applied to qualitative analysis under the positive ion mode,and mass scan range was m/z 100-1 500. Results 31 chemical compounds in Artemisiae argyi folium were identified unequivocally. Conclusion A rapid and efficient RRLC-TOFMS approach for identifying the chemical constituents of Artemisiae argyi folium had been successfully established,which paved a way for quality control and further in vivo studies of Artemisiae argyi folium.
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    [7] 吕 磊,张 海,赵 亮,等.RRLC-TOF/MS快速鉴别中药淫羊藿中43种化学成分[J].第二军医大学学报,2011,32(3):941-946.
    [8] 赵 亮,田文君,吕 磊.HPLC-TOF/MS对中药扶正平消胶囊化学成分的鉴别[J].第二军医大学学报,2012,33(7):770-779.
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    [10] Tian F,Liu L,Dou DQ,et al.Chemical comparison of Artemisia borealis and three Chinese Artemisia plant[J].J Chin Pharm Sci,2007(16):27-32.
    [11] 杨晓军,涂院海.陕西艾叶化学成分的研究[J].天然产物研究与开发,2007,(19):402-403.
    [12] Lopes-Lutz D,Alviano DS,Alviano CS,et al.Screening of chemical composition, antimicrobial and antioxidant activities of Artemisia essential oils[J].Phytochemistry,2008(69):1732-1738.
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    [14] Miron TL,Plaza M,Bahrim G,et al.Chemical composition of bioactive pressurized extracts of Romanian aromatic plants[J].J Chromatogr A,2011,1218(30):4918-4927.
    [15] 高淑丽,刘丽华,张 阳,等.LC-MS/MS法同时测定连翘叶中4种成分的含量[J].中国药房,2013,24(11):1026-1028.
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Rapid identification of chemical components in Artemisiae argyi folium by RRLC-TOFMS

doi: 10.3969/j.issn.1006-0111.2014.06.012
  • 1. Pharmaceutical Analysis Center, School of Pharmacy, Second Military Medical University, Shanghai 200433, China
  • 2. Department of Pharmacy, Eastern Hepatobiliary Surgery Hospital affiliated to Second Military Medical University, Shanghai 200438, China
  • Received Date: 2013-06-09
  • Rev Recd Date: 2013-11-13

Abstract: Objective To identify the chemical components in Artemisiae argyi folium by rapid resolution liquid chromatography-time of flight mass spectrometry (RRLC-TOFMS). Methods The separation was performed on an Agilent Eclipse C18 column (2.1 mmü100 mm,1.8 μm ). The mobile phase consisted of acetonitrile (A) and 0.1% formic acid (B) were in gradient elution.The flowing rate was 0.35 ml/min, the injection volume was 1 μl and the temperature of column was 40℃. Time of flight mass spectrometer (TOFMS) with electro spray ion source (ESI) was applied to qualitative analysis under the positive ion mode,and mass scan range was m/z 100-1 500. Results 31 chemical compounds in Artemisiae argyi folium were identified unequivocally. Conclusion A rapid and efficient RRLC-TOFMS approach for identifying the chemical constituents of Artemisiae argyi folium had been successfully established,which paved a way for quality control and further in vivo studies of Artemisiae argyi folium.

ZHAO Jing, CAO Hong, XING Jun-bo. The fingerprint analysis on Chuanshentong injection by HPLC[J]. Journal of Pharmaceutical Practice and Service, 2013, 31(2): 137-139. doi: 10.3969/j.issn.1006-0111.2013.02.016
Citation: LI Ling, Lü Lei, DONG Xin, LV Diya, LOU Ziyang. Rapid identification of chemical components in Artemisiae argyi folium by RRLC-TOFMS[J]. Journal of Pharmaceutical Practice and Service, 2014, 32(6): 448-452. doi: 10.3969/j.issn.1006-0111.2014.06.012
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