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2014 Vol. 32, No. 5

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Lox-1, a new target in cardiovascular disease
LI Qian, RUI Yaocheng
2014, 32(5): 321-323. doi: 10.3969/j.issn.1006-0111.2014.05.001
Abstract(2997) PDF (168KB)(575)
Abstract:
Objective Lox-1 (lectin-like oxidized low-density lipoprotein receptor-1) was one of the main receptor of ox-LDL, which took an important role in vascular endothelial dysfunction, the formation of foam cells, and the stability of atherosclerotic pla...
Interaction among Toll-like receptors and other pattern recognition receptors in innate immune
XU Jing, DING Li, ZHANG Junping
2014, 32(5): 324-328,400. doi: 10.3969/j.issn.1006-0111.2014.05.002
Abstract(5172) PDF (278KB)(258)
Abstract:
Toll-like receptors (TLRs) are germline-encoded pattern recognition receptors (PRRs) that play a central role in host cell recognition and responses to microbial pathogens. TLRs-mediated recognition of components derived from a wide range of pathogen...
Study on receptor gene polymorphism and detection method of vitamin D
YOU Chunhua, XIONG Xiaojuan, WANG Qinghua, CHEN Wansheng, GAO Shouhong
2014, 32(5): 329-331,392. doi: 10.3969/j.issn.1006-0111.2014.05.003
Abstract(3884) PDF (214KB)(447)
Abstract:
In recent years, many studies have found that vitamin D insufficiency is associated with osteomalacia, hypertension, diabetes, metabolic syndrome and other diseases. Vitamin D must be hydroxylated in the liver by a 25-hydroxylase for the first time, ...
Review of research on dual PI3K-mTOR small molecular inhibitors
CHEN Ying, HAN Jinsong, WANG Chongqing, SONG Yunlong, ZHOU Yonggang, ZHU Ju
2014, 32(5): 332-336,359. doi: 10.3969/j.issn.1006-0111.2014.05.004
Abstract:
Objective The phosphoinositide 3-kinase (PI3K) constituted an important family of lipid kinase enzymes that control a range of cellular proliferation, differentiation and apoptosis through their regulation of a network of signal transduction pathway...
Advance in anti-cancer lead-compounds derived from natural products
WU Shanchao, SHENG Chunquan, ZHANG Wannian
2014, 32(5): 337-341,371. doi: 10.3969/j.issn.1006-0111.2014.05.005
Abstract(3804) PDF (468KB)(316)
Abstract:
Cancer is a serious threat to human life and health. Therefore, there is an emergent need to develop novel anti-cancer agents with new structural type, new mechanism of action and higher efficacy. Natural products had played a key role in the discove...
Solid-phase synthesis of the antifungal tetrapeptide from the culture of penicillium canescens
YANG Lujing, WANG Lu, LI Wenjuan, LI Renwu, WANG Xiaoyan, HU Honggang
2014, 32(5): 342-343,378. doi: 10.3969/j.issn.1006-0111.2014.05.006
Abstract(2897) PDF (412KB)(338)
Abstract:
Objective To synthesize the antifungal tetrapetide by solid-phase synthesis method. Methods The solid-phase peptide synthesis was chosen for getting the desired target tetrapeptide and its structure was confirmed by MS and 1H NMR. Results The syn...
Screening of active compounds of pro-angiogenic in Shexiang Baoxin pill
LV Chao, HUANG Huimei, CHANG Wanlin, LIU Runhui
2014, 32(5): 344-347,351. doi: 10.3969/j.issn.1006-0111.2014.05.007
Abstract:
Objective To screen and identify the main pro-angiogenic compounds of Shexiang Baoxin pill (SBP) presenting in the plasma. Methods The pro-angiogenic effects of SBP and its compounds absorbed into blood were measured by the cell proliferation and c...
Stability of tramadol hydrochloride with fentanyl citrate in 0.9% sodium chloride injection
FANG Baoxia, CHEN Fuchao, LI Chunlei, LIU Huimin, ZHU Xuesong
2014, 32(5): 348-351. doi: 10.3969/j.issn.1006-0111.2014.05.008
Abstract(2934) PDF (301KB)(112)
Abstract:
Objective To study the stability of tramadol hydrochloride with fentanyl citrate in 0.9% sodium chloride injection. Methods The changes in appearance and pH value of the mixture of the two injections in 0.9% sodium chloride injection within 72 hour...
Determination of the polysaccharide in Verdihong paint
YU Xueying, CHANG Mingquan, CHEN Fang, WANG Gang
2014, 32(5): 352-353,356. doi: 10.3969/j.issn.1006-0111.2014.05.009
Abstract(3067) PDF (257KB)(273)
Abstract:
Objective To establish the determination method of the polysaccharide in Verdihong paint. Methods The anhydrous dextrose was used as the control, 0.2% anthrone-sulfuric acid as the stain, the content of polysaccharide was determined by ultraviolet ...
Determination of febuxostate in human plasma by LC-MS-MS
JIANG Nan, YANG Yongge, SONG Lixue, XU Xueting
2014, 32(5): 354-356. doi: 10.3969/j.issn.1006-0111.2014.05.010
Abstract(2903) PDF (442KB)(164)
Abstract:
Objective To establish a LC-MS-MS method for determining febuxostate in human plasma. Methods Febuxostate added into blank plasma was sedimented by acetonitrile, and the supernatant was determined by LC-MS-MS. Analytical column was Thermo Biobasic-...
Study on the identification of raceanisodamine tablets by near infrared spectroscopy
JIA Yanhua, XIONG Chengwen
2014, 32(5): 357-359. doi: 10.3969/j.issn.1006-0111.2014.05.011
Abstract(3136) PDF (226KB)(168)
Abstract:
Objective To develop an identification model of raceanisodamine tablets by diffuse reflection near-infrared spectroscopy and pattern recognition. Methods The diffuse reflectance spectra in the 12 000-4 000 cm-1 spectral coverage range of raceanisod...
Effect of Xinnaoning tablet on blood stasis model in rats
HAO Shaojun, LV Hongdi, LI Jun, SU Feng, ZHANG Zhengchen
2014, 32(5): 360-361,388. doi: 10.3969/j.issn.1006-0111.2014.05.012
Abstract(2822) PDF (170KB)(216)
Abstract:
Objective To study the effect of Xinnaoning tablets on blood stasis rat model which was caused to dexamethasone sodium phosphate injection with symptom score, K-value of blood, modified index, electrophoresis index. Methods 60 rats, were divided in...
Study on synthesis and cyto-toxicity of polyethylene glycol-b-polylysine as potencial miRNA carrier
REN Haifeng, ZHAO Yingkui, YANG Feng, YU Yuan, MA Zhiqiang
2014, 32(5): 362-365,373. doi: 10.3969/j.issn.1006-0111.2014.05.013
Abstract(3640) PDF (836KB)(621)
Abstract:
Objective To synthesize miRNA carrier PEG-b-PLL and to testify the stability, encapsulation efficiency and cytotoxicity of its complexes. Methods H1NMR was used to determine the degree of polymerization of PLL, 4% agarose gel electrophoresis was us...
Validation of method for microbial limit test of fast vertical liquid hand disinfectant gel
TAN Qiaoting, YAN Jia, ZHOU Xin, SONG Hongtao
2014, 32(5): 366-367,382. doi: 10.3969/j.issn.1006-0111.2014.05.014
Abstract(3294) PDF (173KB)(348)
Abstract:
Objective To establish a method for microbial limit test of fast vertical liquid hand disinfectant gel. Methods The membrane filtration method, in accordance with the Chinese Pharmacopoeia 2010 Edition (part two) relevant requirements of microbial ...
Methodology establishment and validation of microbial limit examination of diluted benzalkonium bromide solution
ZHANG Guoqing, DU Jianhong, ZHU Hui, LIU Hui, FANG Chen
2014, 32(5): 368-371. doi: 10.3969/j.issn.1006-0111.2014.05.015
Abstract(3105) PDF (199KB)(420)
Abstract:
Objective To establish a microbial limit examination method and a verified methodology for diluted benzalkonium bromide solution, and ensure the effectiveness of the method. Methods Microbial limit test of diluted benzalkonium bromide solution was ...
Clinical observation of levocarnitine in prevention from peripheral nerve toxicity caused by paclitaxel
YAN Jianwei
2014, 32(5): 372-373. doi: 10.3969/j.issn.1006-0111.2014.05.016
Abstract(2880) PDF (141KB)(167)
Abstract:
Objective To observe levocarnitine in prevention and treatment of peripheral nerve toxicity caused by paclitaxel. Methods 64 cancer patients treated with paclitaxel-based chemotherapy were randomly divided into two groups, the preventive treatment ...
Clinical analysis of compound amino acid(15) and dipeptides(2) injection
XIE Xiaoshuai, CHU Yanqi, BAI Xiangrong, WANG Xing, LIU Ning
2014, 32(5): 374-375,399. doi: 10.3969/j.issn.1006-0111.2014.05.017
Abstract(3428) PDF (178KB)(556)
Abstract:
Objective To investigate the clinical status about the utility of compound amino acid(15) and dipeptides(2) injection, and to promote the rational drug use in our hospital. Methods Data from 127 patients who used compound amino acid(15) and dipepti...
Clinical efficacy for electro-acupuncture and paroxetine in treatment of panic disorder
SONG Weiwei, YAN Lan, ZHOU Hu
2014, 32(5): 376-378. doi: 10.3969/j.issn.1006-0111.2014.05.018
Abstract(3017) PDF (178KB)(124)
Abstract:
Objective To compare the efficacy and safety of the treatment of panic disorder by electro-acupuncture(EA) and paroxetine. Methods 59 patients were randomly divided into paroxetine group (30 cases) and EA group (29 cases), the therapeutic course wa...
Soldiers participate in relief state of emergency under medication analysis
JIN Weihua, ZHANG Qin, TAN Yonghong, CHEN Hua
2014, 32(5): 379-382. doi: 10.3969/j.issn.1006-0111.2014.05.019
Abstract(2748) PDF (205KB)(109)
Abstract:
Objective Through the analysis of the 5.12 earthquake relief soldiers medication, to provide a reference for future emergency treatment relief workers. Methods May 18, 2008 to August 19, the officers and men of our hospital free treatment for eart...
The experience of controling postoperative infection by pharmaceutical consultation from clinical pharmacists
LI Lixia
2014, 32(5): 383-385. doi: 10.3969/j.issn.1006-0111.2014.05.020
Abstract:
Clinical pharmaceutical care for patients with postoperative infection had been carrying out by clinical pharmacy group and a suit of normalized pharmacy consultation on postoperative infection was summarized by using standardized consultation proces...
Interventions of medication errors after the implementation of unit-dose automated dispensing machines in inpatient pharmacy
YANG Jiwen, ZHANG Meiling, CAI Zhen
2014, 32(5): 386-388. doi: 10.3969/j.issn.1006-0111.2014.05.021
Abstract(2876) PDF (172KB)(241)
Abstract:
Objective To Improve inpatient safety of oral drugs, and reduce risk of medication errors. Methods 1 696 oral-order errors caused by prescription and transcription from July to December 2012 were investigated by Excel. Results 979 cases (57.7%) re...
Pharmaceutical care on a diabetic patient with invasive pulmonary aspergillosis
LIU Lina, LIU Xiaodong, ZHAO Limei
2014, 32(5): 389-392. doi: 10.3969/j.issn.1006-0111.2014.05.022
Abstract(2801) PDF (330KB)(130)
Abstract:
Objective To investigate better patient care via the improved use of medicines and pharmaceutical services for hospital inpatients. Methods Through a case of invasive pulmonary aspergillosis in a diabetic patient, the efficacy of prescribed treatme...
Practice of teaching reform in the pharmacy administration curriculums based on improvement of the student's comprehensive abilities
LIU Lanru, ZHU Hong, ZHANG Yining
2014, 32(5): 393-395. doi: 10.3969/j.issn.1006-0111.2014.05.023
Abstract(2983) PDF (165KB)(331)
Abstract:
Objective To reform practice in the pharmacy administration courses for cultivating student's comprehensive quality. Method Reform practice was tried in the aspects of teaching methods, teaching contents, teaching means and evaluations based on the...
2014, 32(5): 396-397. doi: 10.3969/j.issn.1006-0111.2014.05.024
Abstract(2820) PDF (145KB)(324)
Abstract:
2014, 32(5): 398-399. doi: 10.3969/j.issn.1006-0111.2014.05.025
Abstract(2900) PDF (141KB)(167)
Abstract:
2014, 32(5): 400-400. doi: 10.3969/j.issn.1006-0111.2014.05.026
Abstract(2746) PDF (108KB)(204)
Abstract: