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Volume 32 Issue 5
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2014  >  32(5): 342-343,378

YANG Lujing, WANG Lu, LI Wenjuan, LI Renwu, WANG Xiaoyan, HU Honggang. Solid-phase synthesis of the antifungal tetrapeptide from the culture of penicillium canescens[J]. Journal of Pharmaceutical Practice and Service, 2014, 32(5): 342-343,378. doi: 10.3969/j.issn.1006-0111.2014.05.006
Citation: YANG Lujing, WANG Lu, LI Wenjuan, LI Renwu, WANG Xiaoyan, HU Honggang. Solid-phase synthesis of the antifungal tetrapeptide from the culture of penicillium canescens[J]. Journal of Pharmaceutical Practice and Service, 2014, 32(5): 342-343,378. doi: 10.3969/j.issn.1006-0111.2014.05.006
shu

Solid-phase synthesis of the antifungal tetrapeptide from the culture of penicillium canescens

doi: 10.3969/j.issn.1006-0111.2014.05.006
  • 1.

    Brigade of Postgraduate Administration, Second Military Medical University, Shanghai 200433, China

  • 2.

    School of Pharmacy, Second Military Medical University, Shanghai 200433, China

  • Received Date: 2013-04-28
  • Rev Recd Date: 2013-10-22
  • Objective To synthesize the antifungal tetrapetide by solid-phase synthesis method. Methods The solid-phase peptide synthesis was chosen for getting the desired target tetrapeptide and its structure was confirmed by MS and 1H NMR. Results The synthesis of the D-Phe-Val-D-Val-Tyr-OH was realized with yield of 47%. Conclusion The synthetic method was feasible and practical. The desired target tetrapeptide could be used for screening of antifungal activity.
  • [1] Montesinos E, Bardaji E. Synthetic antimicrobial peptides as agricultural pesticides for plant disease control[J]. Chem Biodiver,2008, 5(7):1225-1237.
    [2] Chernysh S, Kim SI, Bekker G, et al. Antiviral and antitumor peptides from insects[J]. Proc Natl Acad Sci, 2002, 99(20):12628-12632.
    [3] Bertinetti BV, Peña NI, Cabrera GM. An antifungal tetrapeptide from the culture of penicillium canescens[J]. Chem Biodiver,2009, 6(8):1178-1184.
    [4] 胡春玲.鳖甲抗肝纤维化活性多肽的固相合成[J]. 医药导报, 2011, 30(5):561-562.
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Solid-phase synthesis of the antifungal tetrapeptide from the culture of penicillium canescens

doi: 10.3969/j.issn.1006-0111.2014.05.006
  • 1. Brigade of Postgraduate Administration, Second Military Medical University, Shanghai 200433, China
  • 2. School of Pharmacy, Second Military Medical University, Shanghai 200433, China
  • Received Date: 2013-04-28
  • Rev Recd Date: 2013-10-22

Abstract: Objective To synthesize the antifungal tetrapetide by solid-phase synthesis method. Methods The solid-phase peptide synthesis was chosen for getting the desired target tetrapeptide and its structure was confirmed by MS and 1H NMR. Results The synthesis of the D-Phe-Val-D-Val-Tyr-OH was realized with yield of 47%. Conclusion The synthetic method was feasible and practical. The desired target tetrapeptide could be used for screening of antifungal activity.

YANG Lujing, WANG Lu, LI Wenjuan, LI Renwu, WANG Xiaoyan, HU Honggang. Solid-phase synthesis of the antifungal tetrapeptide from the culture of penicillium canescens[J]. Journal of Pharmaceutical Practice and Service, 2014, 32(5): 342-343,378. doi: 10.3969/j.issn.1006-0111.2014.05.006
Citation: YANG Lujing, WANG Lu, LI Wenjuan, LI Renwu, WANG Xiaoyan, HU Honggang. Solid-phase synthesis of the antifungal tetrapeptide from the culture of penicillium canescens[J]. Journal of Pharmaceutical Practice and Service, 2014, 32(5): 342-343,378. doi: 10.3969/j.issn.1006-0111.2014.05.006
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