苦参碱衍生物抗关节炎作用研究

留言板

尊敬的读者、作者、审稿人, 关于本刊的投稿、审稿、编辑和出版的任何问题, 您可以本页添加留言。我们将尽快给您答复。谢谢您的支持!

姓名
邮箱
手机号码
标题
留言内容
验证码

x 关闭永久关闭

应中央军委要求，2022年9月起，《药学实践杂志》将更名为《药学实践与服务》，双月刊，正文96页；2023年1月起，拟出版月刊，正文64页，数据库收录情况与原《药学实践杂志》相同。欢迎作者踊跃投稿！

苦参碱衍生物抗关节炎作用研究

解方园, 王甜甜, 许维恒, 辛宝, 周许薇, 张国庆

文章导航 > 药学实践与服务 > 2019 > 37(3): 241-245

解方园, 王甜甜, 许维恒, 辛宝, 周许薇, 张国庆. 苦参碱衍生物抗关节炎作用研究[J]. 药学实践与服务, 2019, 37(3): 241-245. doi: 10.3969/j.issn.1006-0111.2019.03.010

引用本文:

解方园, 王甜甜, 许维恒, 辛宝, 周许薇, 张国庆. 苦参碱衍生物抗关节炎作用研究[J]. 药学实践与服务, 2019, 37(3): 241-245. doi: 10.3969/j.issn.1006-0111.2019.03.010

XIE Fangyuan, WANG Tiantian, XU Weiheng, XIN Bao, ZHOU Xuwei, ZHANG Guoqing. Anti-arthritis effects of matrine derivative in rats[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(3): 241-245. doi: 10.3969/j.issn.1006-0111.2019.03.010

Citation:

XIE Fangyuan, WANG Tiantian, XU Weiheng, XIN Bao, ZHOU Xuwei, ZHANG Guoqing. Anti-arthritis effects of matrine derivative in rats[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(3): 241-245. doi: 10.3969/j.issn.1006-0111.2019.03.010

苦参碱衍生物抗关节炎作用研究

doi: 10.3969/j.issn.1006-0111.2019.03.010

1.
海军军医大学附属东方肝胆外科医院药材科, 上海 200438
2.
海军军医大学药学院生化药学教研室, 上海 200433

Anti-arthritis effects of matrine derivative in rats

1.
Department of Pharmacy, Shanghai Eastern Hepatobiliary Surgery Hospital Affiliated to Naval Medical University, Shanghai 200438, China
2.
Department of Microbiology and Biochemical Pharmacy, School of Pharmacy, Naval Medical University, Shanghai 200433, China

摘要: 目的研究苦参碱衍生物M19对二型胶原诱导性大鼠关节炎（CIA）的治疗作用。方法将60只大鼠随机分为6组，分别为空白组，模型组，吲哚美辛治疗组，M19低、中、高剂量（2.5、5、10 mg/kg）组。采用二型胶原诱导建立关节炎模型，分别对大鼠足趾肿胀和体重进行测定并对关节炎进行评分，HE染色观察大鼠关节软骨及滑膜组织病理变化，Micro-CT观察大鼠骨关节组织损伤情况。结果苦参碱衍生物M19各剂量组均能不同程度降低大鼠关节炎足趾肿胀程度，增加体重，抑制大鼠关节炎性细胞浸润和滑膜增生，并对骨组织具有一定的保护作用。结论苦参碱衍生物M19对二型胶原诱导的关节炎具有一定的治疗作用。
- 苦参碱衍生物 /
- 类风湿性关节炎 /
- 二型胶原 /
- 大鼠
Abstract: Objective To study the therapeutic effects of matrine derivative M19 on type Ⅱcollagen-induced arthritis (CIA) in rats. Methods Sixty rats were randomly divided into six groups:blank group,model group,indomethacin treatment group,M19 low,medium and high dose groups (2.5,5,10 mg/kg).The paw swelling,arthritis index (AI) and body weight were measured for CIA rats.The histopathological changes of joints and synovial tissue were observed by HE staining.The bone destruction was observed with micro-CT. Results Matrine derivative M19 reduced the paw swelling,increased body weight,inhibited inflammatory cell infiltration,ameliorated synovial tissue and bone destruction in CIA rats. Conclusion Matrine derivative M19 has the certain therapeutic effects on CIA.
- matrine derivative /
- rheumatoid arthritis /
- typeⅡcollagen /
- rats

[1]	UHLIG T,MOE R H,KVIEN T K.The burden of disease in rheumatoid arthritis[J].Pharmacoeconomics,2014,32(9):841-851.
[2]	BARTOK B,FIRESTEIN G S.Fibroblast-like synoviocytes:key effector cells in rheumatoid arthritis[J].Immunol Rev,2010,233(1):233-255.
[3]	KIM S C,SOLOMON D H,LIU J,et al. Risk of venous thromboembolism in patients with rheumatoid arthritis:initiating disease-modifying antirheumatic drugs[J].Am J Med,2015,128(5):539.e7-17.
[4]	LIU H M,WANG K J.Therapeutic effect of Captopril on rheumatoid arthritis in rats[J].Asian Pac J Trop Med,2014,7(12):996-999.
[5]	周静,张弦,钱海兵.类风湿性关节炎发病机制的研究进展[J].贵阳中医学院学报,2014,36(5):44-47.
[6]	梁燕,邹豪.类风湿性关节炎药物治疗研究进展[J].海军医学杂志,2014,35(4):332-333.
[7]	LIU N,KAN Q C,ZHANG X J,et al.Upregulation of immunomodulatory molecules by matrine treatment in experimental autoimmune encephalomyelitis[J].Exp Mol Pathol,2014,97(3):470-476.
[8]	SUN N,WANG Z W,WU C H,et al.Antiviral activity and underlying molecular mechanisms of matrine against porcine reproductive and respiratory syndrome virus in vitro[J].Res Vet Sci,2014,96(2):323-327.
[9]	WANG Y,ZHANG S,LIU J,et al.Matrine inhibits the invasive and migratory properties of human hepatocellular carcinoma by regulating epithelial-mesenchymal transition[J].Mol Med Rep,2018,18(1):911-919.
[10]	KAN Q C,LV P,ZHANG X J,et al.Matrine protects neuro-axon from CNS inflammation-induced injury[J].Exp Mol Pathol,2015,98(1):124-130.
[11]	HU H,WANG S,ZHANG C,et al.Synthesis and in vitro inhibitory activity of matrine derivatives towards pro-inflammatory cytokines[J].Bioorg Med Chem Lett,2010,20(24):7537-7539.
[12]	XU W H,HU H G,TIAN Y,et al.Bioactive compound reveals a novel function for ribosomal protein S5 in hepatic stellate cell activation and hepatic fibrosis[J].Hepatology,2014,60(2):648-660.
[13]	XU J,WANG K Q,XU W H,et al.The matrine derivate MASM prolongs survival,attenuates inflammation,and reduces organ injury in murine established lethal sepsis[J].J Infect Dis,2016,214(11):1762-1772.
[14]	LIU Y,QI Y,BAI Z H,et al.A novel matrine derivate inhibits differentiated human hepatoma cells and hepatic cancer stem-like cells by suppressing PI3K/AKT signaling pathways[J].Acta Pharmacol Sin,2017,38(1):120-132.
[15]	倪晨旭,齐阳,许维恒,等.苦参碱衍生物M19对于肿瘤细胞转移的抑制作用[J].现代肿瘤医学,2016,24(21):3341-3344.
[16]	CHEN X,ZHI X,CAO L,et al.Matrine derivate MASM uncovers a novel function for ribosomal protein S5 in osteoclastogenesis and postmenopausal osteoporosis[J].Cell Death Dis,2017,8(9):e3037.
[17]	XU J,QI Y,XU W H,et al.Matrine derivate MASM suppresses LPS-induced phenotypic and functional maturation of murine bone marrow-derived dendritic cells[J].Int Immunopharmacol,2016,36:59-66.

[1]	杨嘉宁, 赵一颖, 肖伟. 七味脂肝方对非酒精性脂肪性肝炎动物模型的药效学评价 . 药学实践与服务, 2024, 42(9): 389-398. doi: 10.12206/j.issn.2097-2024.202404096
[2]	迟文雅, 袁艳, 李伟林, 吴茼妤, 俞媛. 负载骨髓间充质干细胞/白藜芦醇脂质体的水凝胶支架用于创伤性脑损伤治疗 . 药学实践与服务, 2024, 42(): 1-8. doi: 10.12206/j.issn.2097-2024.202406034
[3]	唐淑慧, 凤美娟, 薛智霞, 鲁桂华. 帕博利珠单抗治疗所致免疫相关不良反应与中医体质的相关性研究 . 药学实践与服务, 2024, 42(5): 217-222. doi: 10.12206/j.issn.2097-2024.202311029
[4]	桂明珠, 李静, 李志玲. 儿童伏立康唑的血药浓度与CYP2C19、CYP2C9和CYP3A5基因多态性的相关性研究 . 药学实践与服务, 2024, 42(): 1-5. doi: 10.12206/j.issn.2097-2024.202402020
[5]	孙丹倪, 黄勇, 张嘉宝, 王培. 代谢相关脂肪性肝病的无创诊断与药物治疗 . 药学实践与服务, 2024, 42(10): 411-418. doi: 10.12206/j.issn.2097-2024.202403049
[6]	王耀振, 徐灿, 吕顺莉, 田泾, 张东炜. 钾离子竞争性酸阻滞剂的药学特征研究进展 . 药学实践与服务, 2024, 42(7): 278-284. doi: 10.12206/j.issn.2097-2024.202306040
[7]	张晶晶, 索丽娜, 郑兆红. 89例细菌性肝脓肿的临床特征及抗感染治疗分析 . 药学实践与服务, 2024, 42(6): 267-272. doi: 10.12206/j.issn.2097-2024.202302039
[8]	刘丽艳, 余小翠, 孙传铎. 纳武利尤单抗治疗非小细胞肺癌有效性及安全性的Meta分析 . 药学实践与服务, 2024, 42(10): 451-456. doi: 10.12206/j.issn.2097-2024.202310044
[9]	张艺昕, 关欣怡, 王博宁, 闻俊, 洪战英. 二氢吡啶类钙离子拮抗药物手性分析及其立体选择性药动学研究进展 . 药学实践与服务, 2024, 42(8): 319-324. doi: 10.12206/j.issn.2097-2024.202308062
[10]	戴菲菲, 傅翔, 陈琼年, 俞苏纯. 上海某二级医院革兰阴性菌流行特征的回顾性分析 . 药学实践与服务, 2024, 42(): 1-5. doi: 10.12206/j.issn.2097-2024.202305005
[11]	张广雨, 杜晶, 刘梦珍, 朱丹妮, 闫慧, 刘冲. 新斯的明与山莨菪碱联合应用对肺型氧中毒的保护作用及其机制的研究 . 药学实践与服务, 2024, 42(10): 433-438, 444. doi: 10.12206/j.issn.2097-2024.202310049
[12]	毛智毅, 王筱燕, 陈晓颖, 汤逸斐. 度拉糖肽联合二甲双胍对肥胖型2型糖尿病患者机体代谢、体脂成分及血清脂肪因子的影响 . 药学实践与服务, 2024, 42(7): 305-309. doi: 10.12206/j.issn.2097-2024.202305032
[13]	景凯, 杨慈荣, 张圳, 臧艺蓓, 刘霞. 黄芪甲苷衍生物治疗慢性心力衰竭小鼠的药效评价及作用机制研究 . 药学实践与服务, 2024, 42(5): 190-197. doi: 10.12206/j.issn.2097-2024.202310004

WeChat

点击查看大图

计量

文章访问数: 3593
HTML全文浏览量: 628
PDF下载量: 317
被引次数: 0

苦参碱衍生物抗关节炎作用研究

doi: 10.3969/j.issn.1006-0111.2019.03.010

1. 海军军医大学附属东方肝胆外科医院药材科, 上海 200438

2. 海军军医大学药学院生化药学教研室, 上海 200433

收稿日期: 2018-11-08
修回日期: 2018-12-19

关键词:

苦参碱衍生物 /

类风湿性关节炎 /

摘要: 目的研究苦参碱衍生物M19对二型胶原诱导性大鼠关节炎（CIA）的治疗作用。方法将60只大鼠随机分为6组，分别为空白组，模型组，吲哚美辛治疗组，M19低、中、高剂量（2.5、5、10 mg/kg）组。采用二型胶原诱导建立关节炎模型，分别对大鼠足趾肿胀和体重进行测定并对关节炎进行评分，HE染色观察大鼠关节软骨及滑膜组织病理变化，Micro-CT观察大鼠骨关节组织损伤情况。结果苦参碱衍生物M19各剂量组均能不同程度降低大鼠关节炎足趾肿胀程度，增加体重，抑制大鼠关节炎性细胞浸润和滑膜增生，并对骨组织具有一定的保护作用。结论苦参碱衍生物M19对二型胶原诱导的关节炎具有一定的治疗作用。

English Abstract

解方园, 王甜甜, 许维恒, 辛宝, 周许薇, 张国庆. 苦参碱衍生物抗关节炎作用研究[J]. 药学实践与服务, 2019, 37(3): 241-245. doi: 10.3969/j.issn.1006-0111.2019.03.010

引用本文:

解方园, 王甜甜, 许维恒, 辛宝, 周许薇, 张国庆. 苦参碱衍生物抗关节炎作用研究[J]. 药学实践与服务, 2019, 37(3): 241-245. doi: 10.3969/j.issn.1006-0111.2019.03.010

XIE Fangyuan, WANG Tiantian, XU Weiheng, XIN Bao, ZHOU Xuwei, ZHANG Guoqing. Anti-arthritis effects of matrine derivative in rats[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(3): 241-245. doi: 10.3969/j.issn.1006-0111.2019.03.010

Citation:

XIE Fangyuan, WANG Tiantian, XU Weiheng, XIN Bao, ZHOU Xuwei, ZHANG Guoqing. Anti-arthritis effects of matrine derivative in rats[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(3): 241-245. doi: 10.3969/j.issn.1006-0111.2019.03.010

全文HTML

参考文献 (17)

/

下载: 全尺寸图片幻灯片

分享

用微信扫码二维码

分享至好友和朋友圈

返回

版权所有：《药学实践与服务》编辑委员会

主管、主办: 中国人民解放军海军军医大学地址: 上海市杨浦区国和路325号邮政编码: 200433

电话: （021）81871324,81871397 E-mail: yxsjzzs@163.com

网站备案号沪ICP备05003363号-1

本系统由北京仁和汇智信息技术有限公司开发