Study on the effects of different humidifying liquids applied to non-invasive mechanical ventilation airway humidification
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摘要: 目的 比较不同气道湿化液应用于无创机械通气的效果。 方法 将2016年5月至2017年5月收入东方肝胆外科医院的121例无创机械通气患者，按照随机数字表法分为A、B、C组。A组40例患者湿化液为灭菌注射用水；B组40例患者湿化液为0.9%氯化钠溶液；C组41例患者湿化液为稀释后浓度为1.25%碳酸氢钠溶液。比较3组痰液的黏稠度和湿化舒适度。 结果 第1天3组的痰液黏稠度组间比较，差异无统计学意义（F=0.230，P=0.795）；第2天3组痰液黏稠度比较，A组黏稠度最高，B组次之，C组最低，差异有统计学意义，（F=4.416，P<0.05）。第3天3组痰液黏稠度比较，A组黏稠度最高，B组次之，C组最低，差异有统计学意义（F=11.388，P<0.001）。3组湿化后舒适度评分C组最优，组间比较有统计学意义（F=37.901，P<0.001）。 结论 1.25%碳酸氢钠溶液湿化可以使痰液更为稀释，湿化后患者舒适度较好，对于痰液较多的患者可以优先考虑使用其作为无创呼吸机湿化液。Abstract: Objective To study the effects of different airway humidification fluid applied to non-invasive mechanical ventilation. Methods 121 cases of non-invasive mechanical ventilation admitted to the hospital from May 2016 to May 2017 were randomly divided into three groups.40 cases in group A received sterile water for injection as humidifying liquid.40 cases in group B received normal saline and 41 cases in group C received 1.25% sodium bicarbonate water solution.The viscosity of sputum and the comfort of humidification for the three groups were compared. Results On day 1, there was no significant difference in the sputum viscosity among the three groups.(F=0.230, P=0.795). On day 2, group A had the highest sputum viscosity, followed by group B and group C.The difference was statistically significant (F=4.416, P<0.05).The same results were obtained on day 3 with statistically significant difference (F=11.388, P<0.001).Group C had the highest comfort score among the three groups with statistically significant difference (F=37.901, P<0.001). Conclusion 1.25% sodium bicarbonate water solution makes sputum more diluted and gives patients with better comfort.It can be considered as the fluid of choice for patients with high sputum amount.
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