留言板

尊敬的读者、作者、审稿人, 关于本刊的投稿、审稿、编辑和出版的任何问题, 您可以本页添加留言。我们将尽快给您答复。谢谢您的支持!

姓名
邮箱
手机号码
标题
留言内容
验证码

重要提示

《药学实践与服务》杂志不接收生物战剂、毒剂相关内容的稿件。对于涉军信息类论文如需投稿,请务必投稿前电话或邮箱咨询。联系电话:021-81871323,邮箱:yxsjzzs@163.com。敬请谅解,谢谢配合!

《药学实践与服务》编辑部

重要通知

药学实践与服务》杂志目前不收取审稿费、版面费、加急费等费用,如收到邮件声称是编辑部X编辑,要求加作者微信的,或填写编委登记申请表的,请谨防诈骗!

编辑部用于作者校稿时微信绑定的邮件是通过官方邮箱:yxsjzzs@163.com发送的,标题是《药学实践与服务》XML数字出版服务微信绑定,请区分开!如有疑虑,请联系编辑部,电话:021-81871323。

《药学实践与服务》编辑部

载药金纳米粒的研究进展

张鑫 刘颖 冯年平

张鑫, 刘颖, 冯年平. 载药金纳米粒的研究进展[J]. 药学实践与服务, 2016, 34(3): 196-200,236. doi: 10.3969/j.issn.1006-0111.2016.03.002
引用本文: 张鑫, 刘颖, 冯年平. 载药金纳米粒的研究进展[J]. 药学实践与服务, 2016, 34(3): 196-200,236. doi: 10.3969/j.issn.1006-0111.2016.03.002
ZHANG Xin, LIU Ying, FENG Nianping. Research progress of drug-loading gold nanoparticles[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(3): 196-200,236. doi: 10.3969/j.issn.1006-0111.2016.03.002
Citation: ZHANG Xin, LIU Ying, FENG Nianping. Research progress of drug-loading gold nanoparticles[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(3): 196-200,236. doi: 10.3969/j.issn.1006-0111.2016.03.002

载药金纳米粒的研究进展

doi: 10.3969/j.issn.1006-0111.2016.03.002
基金项目: 国家自然科学基金项目(81202925)

Research progress of drug-loading gold nanoparticles

  • 摘要: 近年来,作为一种新型药物递送系统,金纳米粒已引起了广泛关注。由于其特殊的物理化学性质,能与多种类型药物发生相互作用,如蛋白质、核酸、小分子药物等,从而可应用于肿瘤治疗和检测。笔者对载药金纳米粒的制备方法、载药方式和安全性等问题进行综述。
  • [1] Luan QF, Zhou KB, Tan HN, et al. Au-NPs enhanced SPR biosensor based on hairpin DNA without the effect of nonspecific adsorption[J]. Biosens Bioelectron, 2011, 26(5):2473-2477.
    [2] Lee H, Lee K, Kim IK, et al. Fluorescent gold nanoprobe sensitive to intracellular reactive oxygen species[J].Adv Funct Mater, 2009, 19(12):1884-1890.
    [3] Rana S, Bajaj A, Mout R, et al. Monolayer coated gold nanoparticles for delivery applications[J]. Adv Drug Deliv Rev, 2012, 64(2):200-216.
    [4] Kumar A, Zhang X, Liang XJ. Gold nanoparticles:Emerging paradigm for targered drug delivery system[J]. Biotechnol Adv, 2013, 31(5):593-606.
    [5] Li L, Nurunnabi M, Nafiujjaman M, et al. GSH-mediated photoactivity of pheophorbide a-conjugated haparin/gold nanoparticle for photodynamic therapy[J]. J Control Release, 2013, 171:241-250.
    [6] Rahman WN, Corde S, Yaqi N, et al. Optimal energy for cell radiosensitivity enhancement by gold nanoparticles using synchrotron-based monoenergetic photo beams[J]. Int J Nanomedicine, 2014, 9:2459-2467.
    [7] Van de Broek B, Devoogdt N, D'Hollander A, et al. Specific cell targeting with nanobody conjugated branched gold nanoparticles for photothermal therapy[J]. ACS Nano, 2011, 5(6):4319-4328.
    [8] Ganeshkumar M, Ponrasu T, Raja MT, et al. Green synthesis of pullulan stabilized gold nanoparticles for cancer targeted drug delivery[J]. Spectrochim Acta A Mol Biomol Spectrosc, 2014, 130:64-71.
    [9] Southam G, Beveridge TJ. The occurence of sulfur and phosphorus within bacterially derived crystalline and pseudocrystalline octahedral gold formed in vitro[J]. Geochim Cosmochim Acta, 1996, 60(20):4369-4376.
    [10] Wen L, Lin ZH, Gu PY, et al. Extracellular biosynthesis of monodispersed gold nanoparticles by a SAM capping route[J]. J Nanopart Res, 2009, 11(2):279-288.
    [11] Kumar KP, Paul W, Sharma CP. Green synthesis of gold nanoparticles with Zingiber officinale extract:Characterization and blood compatibility[J]. Process Biochem, 2011, 46(10):2007-2013.
    [12] Guo QQ, Guo QL, Yuan J, et al. Biosynthesis of gold nanoparticles using a kind of flavonol Dihydromyricetin[J]. Colloids Suraces A Physicochem Eng Asp, 2014, 441:127-132.
    [13] Woehrle GH, Brown LO, Hutchison JE. Thiol-functionalized,1.5-nm gold nanoparticles through ligand exchange reactions:scope and mechanism of ligand exchange[J]. J Am Chem Soc, 2005, 127(7):2172-2183.
    [14] Shem PM, Sardar R, Shumaker-parry JS. Soft ligand stabilized gold nanoparticles:Incorporation of bipyridyls and two-dimensional assembly[J]. J Colloid Interface Sci, 2014, 426:107-116.
    [15] Tatarchuk VV, Sergievskaya AP, Zaikovsky VI, et al. Hydrophilic gold nanoparticles stabilized with tris(2-aminoethyl)amine:Preparation and characterization[J]. Colloids Surf A Physicochem Eng Asp, 2014, 441:496-503.
    [16] Hamaguchi K, Kawasaki H, Arakawa R.Photochemical synthesis of glycine-stabilized gold nanoparticles and its heavy-metal-induced aggregation behavior[J]. Colloids Surf A Physicochem Eng Asp, 2010, 367(1-3):167-173.
    [17] Kim ST, Chompoosor A, Yeh YC, et al. Dendronized gold nanoparticles for siRNA delivery[J]. Small, 2012, 8(21):3253-3256.
    [18] Kim CK, Ghosh P, Pagliuca C, et al. Entrapment of hydrophobic drugs in nanoparticle monolayers with efficient release into cancer cells[J]. J Am Chem Soc, 2009, 131(4):1360-1361.
    [19] Ding Y, Zhou YY, Chen H,et al. The performance of thiol-terminated PEG paclitaxel-conjugated gold nanoparticles[J]. Biomaterials, 2013, 34(38):10217-10227.
    [20] Brown SD, Nativo P, Smith JA, et al. Gold nanoparticles for the improved anticancer drug delivery of the active component of oxaliplatin[J]. J Am Chem Soc, 2010, 132(13):4678-4684.
    [21] Sánchez-Paradinas S, Pérez-Andrés M, Almendral-Parra MJ, et al. Enhanced cytotoxic activity of bile acid cisplatin derivatives by conjugation with gold nanoparticles[J]. J Inorq Biochem, 2014, 131:8-11.
    [22] Kao HW,Lin YY,Chen CC, et al. Biological characterization of cetuximab-conjugated gold nanoparticles in a tumor animal model[J]. Nanotechnology, 2014, 25(29):295102.
    [23] Joshi P, Chakraborti S, Ramirez-Vick JE, et al. The anticancer activity of chloroquine gold nanoparticles against MCF-7 breast cancer cells[J]. Colloids Surf B Biointerfaces, 2012, 95(15):195-200.
    [24] Vigderman L, Zubarev ER. Therapeutic platforms based on gold nanoparticles and their covalent conjugates with drug molecles[J]. Adv Drug Deliv Rev, 2013, 65(5):663-676.
    [25] Choi CH, Alabi CA, Webster P, et al. Mechanism of active targeting in solid tumors with transferrin-containing gold nanoparticles[J]. Proc Nati Acad Sci U S A, 2010, 107(3):1235-1240.
    [26] Zhang ZW, Jia J, Lai YQ, et al. Conjugating folic acid to gold nanoparticles through glutathione for targeting and detecting cancer cells[J]. Bioorg Med Chem, 2010, 18(15):5528-5534.
    [27] Marangoni VS, Paino IM, Zucolotto V. Synthesis and characterization of jacalin-gold nanoparticles conjugates as specific markers for cancer cells[J]. Colloids Surf B Biointerfaces, 2013, 112:380-386.
    [28] Eshghi H, Sazgarnia A, Rahimizadeh M, et al. Protoporphyrin Ⅸ-gold nanoparticle conjugates as an efficient photosensitizer in cervical cancer therapy[J]. Photodiagnosis Photodyn Ther, 2013, 10(3):304-312.
    [29] Bao QY, Geng DD, Xue JW, et al. Glutathione-mediated drug release from Tiopronin-conjugated gold nanoparticles for acute liver injury therapy[J]. Int J Pharm, 2013, 446(1-2):112-118.
    [30] Shen GY,Zhang SB, Hu X. Signal enhancement in a lateral flow immunoassay based on dual gold nanoparticle conjugates[J]. Clin Biochem, 2013, 46(16-17):1734-1738.
    [31] Liu L, Du J, Li SJ, et al. Amplified voltammetric detection of dopamine using ferrocene-capped gold nanoparticle/streptavidin conjugates[J]. Biosens Bioelectron, 2013, 41:730-735.
    [32] Figueroa ER, Lin AY, Yan JX, et al. Optimization of PAMAM-gold nanoparticle conjugation for gene therapy[J]. Biomaterials, 2014, 35(5):1725-1734.
    [33] Haller E, Lindner W, Lämmerhofer M. Gold nanoparticle-antibody conjugates for specific extraction and subsequent analysis by liquid chromatography-tandem mass spectrometry of malondialdehyde-modified low density lipoprotein as biomarker for cardiovascular[J]. Anal Chim Acta, 2015, 857:53-63.
    [34] Ramezani F, Habibi M, Rafii-Tabar H, et al. Effect of peptide length on the conjugation to the gold nanoparticle surface:a molecular dynamic study[J]. Daru, 2015, 23(1):9-13.
    [35] Li N, Zhao PX, Astruc D. Anisotropic gold nanoparticles:synthesis, properties, applications, and toxicity[J]. Angew Chem Int Ed Engl, 2014,53(7):1756-1789.
    [36] Connor EE, Mwamuka J, Gole A, et al. Gold nanoparticles are taken up by human cells but do not cause acute cytotoxicity[J]. Small, 2005, 1(3):325-327.
  • [1] 胡文宇, 史文俊, 王学武, 李硕硕.  金线莲苷对小鼠酒精性肝损伤的作用机制研究 . 药学实践与服务, 2026, 44(1): 12-19. doi: 10.12206/j.issn.2097-2024.202309030
    [2] 周文铂, 李伟林, 戴吴婷, 刘瑞瑶, 俞媛.  载葡萄糖氧化酶纳米凝胶的构建 及对胶质瘤细胞Warburg效应的抑制 . 药学实践与服务, 2026, 44(): 1-6. doi: 10.12206/j.issn.2097-2024.202511030
    [3] 倪晓霞, 陈巧秀, 杨育儒, 曹毅祥.  基于谱效关系的黄连不同方法提取物抑菌作用物质基础初步研究 . 药学实践与服务, 2026, 44(2): 80-84. doi: 10.12206/j.issn.2097-2024.202403054
    [4] 王彦, 康乐, 陈文, 方琦, 俞仲望, 曹莉.  基于CiteSpace结合系统评价方法分析药品不良反应自动监测系统的热点及优势 . 药学实践与服务, 2025, 43(): 1-8. doi: 10.12206/j.issn.2097-2024.202501034
    [5] 孙波, 吕宗强, 罗宁, 李荣, 王洪祥, 陈菊祥.  Angiopep-2修饰的细菌外囊泡载药系统治疗胶质母细胞瘤效果研究 . 药学实践与服务, 2025, 43(10): 481-490. doi: 10.12206/j.issn.2097-2024.202506017
    [6] 陈明, 王晨佳, 唐原君, 汪硕闻, 范国荣.  呋喹替尼的治疗药物监测方法构建及其临床应用 . 药学实践与服务, 2025, 43(12): 610-613. doi: 10.12206/j.issn.2097-2024.202412043
    [7] 沈娟, 田瑛, 倪明, 刘炬, 于蒙蒙.  喷替酸原料药细菌内毒素限值确定及检查方法学研究 . 药学实践与服务, 2025, 43(12): 607-609, 624. doi: 10.12206/j.issn.2097-2024.202508061
    [8] 肖农, 陆诗依, 唐文雅, 居敏俐, 徐刚锋, 杨明华.  中成药微生物计数法前处理的影响因素和优化方法 . 药学实践与服务, 2025, 43(8): 373-376, 409. doi: 10.12206/j.issn.2097-2024.202403014
    [9] 高锦, 胡丹, 马紫辉, 徐君伟, 高青, 洪小栩.  滴眼液中抑菌剂硫柳汞的HPLC含量测定方法研究 . 药学实践与服务, 2025, 43(6): 293-297. doi: 10.12206/j.issn.2097-2024.202404059
    [10] 刘安泽, 何盈盈, 王欢, 鲁莹.  基于天然IgM新型佐剂的叶酸脂质体疫苗制备及评价 . 药学实践与服务, 2025, 43(11): 555-559. doi: 10.12206/j.issn.2097-2024.202401060
    [11] 王文涛, 高兴, 赵凤平, 郑灿辉, 陈新.  异硒唑酮类化合物在疾病治疗中的作用和化学合成方法 . 药学实践与服务, 2025, 43(8): 367-372. doi: 10.12206/j.issn.2097-2024.202308064
    [12] 郭灵怡, 刘艳超, 高路, 刘瑞瑶, 吕权真, 俞媛.  醋酸卡泊芬净单硬脂酸甘油酯纳米粒抗白色念珠菌感染的增效作用研究 . 药学实践与服务, 2025, 43(3): 136-142, 150. doi: 10.12206/j.issn.2097-2024.202310043
    [13] 陈官旭, 宋雨桐, 郭秀强, 张咪, 刘志宏, 宋洪涛.  EGFR-TKIs单药及其联合方案在晚期非小细胞肺癌一线治疗中的疗效与安全性比较:网状Meta分析 . 药学实践与服务, 2025, 43(): 1-11. doi: 10.12206/j.issn.2097-2024.202504044
    [14] 周丽城, 欧已铭, 王园.  玉米须黄酮化学成分与药理作用研究进展 . 药学实践与服务, 2025, 43(2): 51-58. doi: 10.12206/j.issn.2097-2024.202309037
    [15] 邹思, 吴岩斌, 吴锦忠, 吴建国, 黄家兴.  虎奶菇菌核多糖功能化纳米硒抗疲劳功效研究 . 药学实践与服务, 2024, 42(10): 426-432. doi: 10.12206/j.issn.2097-2024.202206072
    [16] 顾佳钰, 胡馨儿, 王晓飞, 张颖, 张海, 曹岩.  侧流免疫层析定量检测方法的研究进展 . 药学实践与服务, 2024, 42(7): 273-277, 284. doi: 10.12206/j.issn.2097-2024.202307037
    [17] 岳春华, 贲永光, 王海桥.  基于NLRP1炎症小体探讨百合知母汤抗抑郁的作用机制 . 药学实践与服务, 2024, 42(8): 325-333. doi: 10.12206/j.issn.2097-2024.202401033
    [18] 凯丽比努尔·奥布力艾散, 李倩, 谢志, 贾文彦, 尹东锋.  星点设计-效应面法优化仑伐替尼混合胶束的制备工艺 . 药学实践与服务, 2024, 42(11): 495-502. doi: 10.12206/j.issn.2097-2024.202403019
    [19] 陈炳辰, 王思真, 郭贝贝, 杨峰.  紫杉醇棕榈酸酯的合成及其脂质体的制备与处方研究 . 药学实践与服务, 2024, 42(9): 379-384, 410. doi: 10.12206/j.issn.2097-2024.202404062
    [20] 刘丽艳, 余小翠, 孙传铎.  纳武利尤单抗治疗非小细胞肺癌有效性及安全性的Meta分析 . 药学实践与服务, 2024, 42(10): 451-456. doi: 10.12206/j.issn.2097-2024.202310044
  • 加载中
计量
  • 文章访问数:  5135
  • HTML全文浏览量:  655
  • PDF下载量:  22
  • 被引次数: 0
出版历程
  • 收稿日期:  2015-10-29
  • 修回日期:  2016-01-29

载药金纳米粒的研究进展

doi: 10.3969/j.issn.1006-0111.2016.03.002
    基金项目:  国家自然科学基金项目(81202925)

摘要: 近年来,作为一种新型药物递送系统,金纳米粒已引起了广泛关注。由于其特殊的物理化学性质,能与多种类型药物发生相互作用,如蛋白质、核酸、小分子药物等,从而可应用于肿瘤治疗和检测。笔者对载药金纳米粒的制备方法、载药方式和安全性等问题进行综述。

English Abstract

张鑫, 刘颖, 冯年平. 载药金纳米粒的研究进展[J]. 药学实践与服务, 2016, 34(3): 196-200,236. doi: 10.3969/j.issn.1006-0111.2016.03.002
引用本文: 张鑫, 刘颖, 冯年平. 载药金纳米粒的研究进展[J]. 药学实践与服务, 2016, 34(3): 196-200,236. doi: 10.3969/j.issn.1006-0111.2016.03.002
ZHANG Xin, LIU Ying, FENG Nianping. Research progress of drug-loading gold nanoparticles[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(3): 196-200,236. doi: 10.3969/j.issn.1006-0111.2016.03.002
Citation: ZHANG Xin, LIU Ying, FENG Nianping. Research progress of drug-loading gold nanoparticles[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(3): 196-200,236. doi: 10.3969/j.issn.1006-0111.2016.03.002
参考文献 (36)

目录

    /

    返回文章
    返回