药物辅料中有毒掺杂物的拉曼/近红外光谱法检测灵敏度评价

留言板

尊敬的读者、作者、审稿人, 关于本刊的投稿、审稿、编辑和出版的任何问题, 您可以本页添加留言。我们将尽快给您答复。谢谢您的支持!

姓名
邮箱
手机号码
标题
留言内容
验证码

x 关闭永久关闭

应中央军委要求，2022年9月起，《药学实践杂志》将更名为《药学实践与服务》，双月刊，正文96页；2023年1月起，拟出版月刊，正文64页，数据库收录情况与原《药学实践杂志》相同。欢迎作者踊跃投稿！

药物辅料中有毒掺杂物的拉曼/近红外光谱法检测灵敏度评价

张中湖, 李皓, 李军, 陆峰

文章导航 > 药学实践与服务 > 2015 > 33(5): 441-444

张中湖, 李皓, 李军, 陆峰. 药物辅料中有毒掺杂物的拉曼/近红外光谱法检测灵敏度评价[J]. 药学实践与服务, 2015, 33(5): 441-444. doi: 10.3969/j.issn.1006-0111.2015.05.016

引用本文:

张中湖, 李皓, 李军, 陆峰. 药物辅料中有毒掺杂物的拉曼/近红外光谱法检测灵敏度评价[J]. 药学实践与服务, 2015, 33(5): 441-444. doi: 10.3969/j.issn.1006-0111.2015.05.016

ZHANG Zhonghu, LI Hao, LI Jun, LU Feng. The sensitivity evaluation of Raman spectroscopy and near infrared spectroscopy; in toxic adulterant detection of pharmaceutical excipient[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(5): 441-444. doi: 10.3969/j.issn.1006-0111.2015.05.016

Citation:

ZHANG Zhonghu, LI Hao, LI Jun, LU Feng. The sensitivity evaluation of Raman spectroscopy and near infrared spectroscopy; in toxic adulterant detection of pharmaceutical excipient[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(5): 441-444. doi: 10.3969/j.issn.1006-0111.2015.05.016

药物辅料中有毒掺杂物的拉曼/近红外光谱法检测灵敏度评价

doi: 10.3969/j.issn.1006-0111.2015.05.016

张中湖¹,
李皓²,
李军¹,
陆峰^2,

1.
山东省食品药品检验研究院, 山东济南 250101
2.
第二军医大学药学院, 上海 200433

基金项目: 科技部重大科学仪器设备开发专项(2012YQ180132)

The sensitivity evaluation of Raman spectroscopy and near infrared spectroscopy; in toxic adulterant detection of pharmaceutical excipient

1.
Shandong Institute for Food and Drug Control, Jinan 250101, China
2.
School of Pharmacy, Second Military Medical University, Shanghai 200433, China

摘要: 目的建立常用药物辅料(甘油)中有毒掺杂物(二甘醇)的快速检测方法。方法利用拉曼/近红外光谱法结合移动窗口相关系数法评价有毒掺杂物的检测灵敏度。结果拉曼光谱下获得的检测灵敏度优于近红外光谱,同时移动窗口法可进一步提高检测灵敏度。结论拉曼光谱法有望成为现场快速检测药物辅料中掺杂有毒物质的有效方法。
- 药物辅料 /
- 拉曼光谱法 /
- 近红外光谱法 /
- 灵敏度 /
- 移动窗口
Abstract: Objective To develop a rapid method for the detection of toxic adulterant (diethylene glycol) in pharmaceutical excipient (glycerol). Method The detection sensitivity of Raman/ near infrared (NIR) spectroscopy combined with moving window correlation coefficient (MWCC) method was evaluated. Results The detection sensitivity of Raman spectroscopy was superior to that of NIR spectroscopy and with the assistance of MWCC method; the sensitivity had been further improved. Conclusion Raman spectroscopy has the potential to become the effective method in the on-site detection of toxic adulterant in pharmaceutical excipient.
- pharmaceutical excipient /
- Raman spectroscopy /
- near infrared (NIR) spectroscopy /
- sensitivity /
- moving window correlation coefficient (MWCC) method

[1]	Khalique MA,Michael PM,Jean N,et al.Fourier transform infrared and near-infrared spectroscopic methods for the detection of toxic diethylene glycol (DEG) contaminant in glycerin based cough syrup[J]. Spectrosc, 2010, 24: 601-608.
[2]	Lin BL, Zhao ZX, Chong YT, et al. Venous diethylene glycol poisoning in patients with preexisting severe liver disease in China[J]. World J Gastroenterol, 2008,14: 3236-3241.
[3]	Yua H, Cornettb C, Larsenb J, et al. Reaction between drug substances and pharmaceutical excipients: formation of esters between cetirizine and polyols[J]. J Pharm Biomed Anal, 2010, 53: 745-750.
[4]	Liltorp K, Larsenb TG, Willumsenb B, et al. Solid state compatibility studies with tablet excipients using non thermal methods[J]. J Pharm Biomed Anal, 2011, 55: 424-428.
[5]	Ali EMA, Edwards HGM, Scowen IJ. In-situ detection of single particles of explosive on clothing with confocal Raman microscopy[J]. Talanta, 2009, 78: 1201-1203.
[6]	Lyndgaard LB, van den BF, de Juan A. Quantification of paracetamol through tablet blister packages by Raman spectroscopy and multivariate curve resolution-alternating least squares[J]. Chemom Intell Lab Syst, 2013,125: 58-66.
[7]	Rodriguez JD, Westenberger BJ, Buhse LF, et al. Quantitative evaluation of the sensitivity of library-based Raman spectral correlation methods[J]. Anal Chem, 2011, 83 : 4061-4067.
[8]	Kim J, Hwang J, Chung H. Comparison of near-infrared and Raman spectroscopy for on-line monitoring of etchant solutions directly through a Teflon tube[J]. Anal Chim Acta, 2008, 629: 119-127.
[9]	Chu XL, Xu YP, Tian SB, et al. Rapid identification and assay of crude oils based on moving-window correlation coefficient and near infrared spectral library[J]. Chemom Intell Lab Syst, 2011, 107: 44-49.
[10]	Du YP, Liang YZ, Jiang JH, et al. Spectral regions selection to improve prediction ability of PLS models by changeable size moving window partial least squares and searching combination moving window partial least squares[J]. Anal Chim Acta, 2004, 501: 183-191.
[11]	Ruzicka CMG, Arzhantsev S, Pelster LN, et al. Multivariate calibration and instrument standardization for the rapid detection of diethylene glycol in glycerin by Raman spectroscopy[J]. Appl Spectrosc, 2011, 65 : 334-341.

[1]	宋雨桐, 夏德润, 顾珩, 唐少文, 易洪刚, 沃红梅. 帕博利珠单抗与铂类化疗方案在晚期非小细胞肺癌一线治疗中的药物经济学评价 . 药学实践与服务, 2024, 42(8): 334-340. doi: 10.12206/j.issn.2097-2024.202303023
[2]	张艺昕, 关欣怡, 王博宁, 闻俊, 洪战英. 二氢吡啶类钙离子拮抗药物手性分析及其立体选择性药动学研究进展 . 药学实践与服务, 2024, 42(8): 319-324. doi: 10.12206/j.issn.2097-2024.202308062
[3]	夏哲炜, 曾垣烨, 朱海菲, 李育, 陈啸飞. 核磁共振磷谱法测定磷酸氢钙咀嚼片中药物含量 . 药学实践与服务, 2024, 42(9): 399-401, 406. doi: 10.12206/j.issn.2097-2024.202404063
[4]	孙丹倪, 黄勇, 张嘉宝, 王培. 代谢相关脂肪性肝病的无创诊断与药物治疗 . 药学实践与服务, 2024, 42(10): 411-418. doi: 10.12206/j.issn.2097-2024.202403049
[5]	陈怡君, 王卓, 何苗, 张宇, 田泾. 泌尿系统碎石术抗菌药物预防使用合理管控实践 . 药学实践与服务, 2024, 42(): 1-5. doi: 10.12206/j.issn.2097-2024.202402034
[6]	张岩, 李炎君, 刘家荟, 邓娇, 原苑, 张敬一. 药物性肝损伤不良反应分析 . 药学实践与服务, 2024, 42(): 1-5. doi: 10.12206/j.issn.2097-2024.202404034
[7]	张元林, 宋凯, 孙蕊, 舒飞, 舒丽芯, 杨樟卫. 基于真实世界数据的药物利用研究综述 . 药学实践与服务, 2024, 42(6): 238-243. doi: 10.12206/j.issn.2097-2024.202312010
[8]	凯丽比努尔·奥布力艾散, 李倩, 谢志, 贾文彦, 尹东锋. 星点设计-效应面法优化仑伐替尼混合胶束的制备工艺 . 药学实践与服务, 2024, 42(11): 495-502. doi: 10.12206/j.issn.2097-2024.202403019
[9]	毛智毅, 王筱燕, 陈晓颖, 汤逸斐. 度拉糖肽联合二甲双胍对肥胖型2型糖尿病患者机体代谢、体脂成分及血清脂肪因子的影响 . 药学实践与服务, 2024, 42(7): 305-309. doi: 10.12206/j.issn.2097-2024.202305032
[10]	姚小静, 计佩影, 陆峰, 施国荣, 傅翔. 表面增强拉曼光谱法快速测定尿液中曲马多的研究 . 药学实践与服务, 2024, 42(): 1-5. doi: 10.12206/j.issn.2097-2024.202401072

WeChat

点击查看大图

计量

文章访问数: 3483
HTML全文浏览量: 325
PDF下载量: 575
被引次数: 0

药物辅料中有毒掺杂物的拉曼/近红外光谱法检测灵敏度评价

doi: 10.3969/j.issn.1006-0111.2015.05.016

1. 山东省食品药品检验研究院, 山东济南 250101

2. 第二军医大学药学院, 上海 200433

基金项目: 科技部重大科学仪器设备开发专项(2012YQ180132)

收稿日期: 2015-05-29
修回日期: 2015-07-26

关键词:

拉曼光谱法 /

近红外光谱法 /

摘要: 目的建立常用药物辅料(甘油)中有毒掺杂物(二甘醇)的快速检测方法。方法利用拉曼/近红外光谱法结合移动窗口相关系数法评价有毒掺杂物的检测灵敏度。结果拉曼光谱下获得的检测灵敏度优于近红外光谱,同时移动窗口法可进一步提高检测灵敏度。结论拉曼光谱法有望成为现场快速检测药物辅料中掺杂有毒物质的有效方法。

English Abstract

张中湖, 李皓, 李军, 陆峰. 药物辅料中有毒掺杂物的拉曼/近红外光谱法检测灵敏度评价[J]. 药学实践与服务, 2015, 33(5): 441-444. doi: 10.3969/j.issn.1006-0111.2015.05.016

引用本文:

张中湖, 李皓, 李军, 陆峰. 药物辅料中有毒掺杂物的拉曼/近红外光谱法检测灵敏度评价[J]. 药学实践与服务, 2015, 33(5): 441-444. doi: 10.3969/j.issn.1006-0111.2015.05.016

ZHANG Zhonghu, LI Hao, LI Jun, LU Feng. The sensitivity evaluation of Raman spectroscopy and near infrared spectroscopy; in toxic adulterant detection of pharmaceutical excipient[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(5): 441-444. doi: 10.3969/j.issn.1006-0111.2015.05.016

Citation:

ZHANG Zhonghu, LI Hao, LI Jun, LU Feng. The sensitivity evaluation of Raman spectroscopy and near infrared spectroscopy; in toxic adulterant detection of pharmaceutical excipient[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(5): 441-444. doi: 10.3969/j.issn.1006-0111.2015.05.016

全文HTML

参考文献 (11)

/

下载: 全尺寸图片幻灯片

分享

用微信扫码二维码

分享至好友和朋友圈

返回

版权所有：《药学实践与服务》编辑委员会

主管、主办: 中国人民解放军海军军医大学地址: 上海市杨浦区国和路325号邮政编码: 200433

电话: （021）81871324,81871397 E-mail: yxsjzzs@163.com

网站备案号沪ICP备05003363号-1

本系统由北京仁和汇智信息技术有限公司开发