留言板

尊敬的读者、作者、审稿人, 关于本刊的投稿、审稿、编辑和出版的任何问题, 您可以本页添加留言。我们将尽快给您答复。谢谢您的支持!

姓名
邮箱
手机号码
标题
留言内容
验证码
x 关闭 永久关闭

应中央军委要求，2022年9月起，《药学实践杂志》将更名为《药学实践与服务》，双月刊，正文96页；2023年1月起，拟出版月刊，正文64页，数据库收录情况与原《药学实践杂志》相同。欢迎作者踊跃投稿！

微针透皮给药系统应用研究进展

万展,  周剑,  韩美娜,  杨峰

downloadPDF
文章导航 > 药学实践与服务  > 2012 >  30(2): 86-88,142
万展, 周剑, 韩美娜, 杨峰. 微针透皮给药系统应用研究进展[J]. 药学实践与服务, 2012, 30(2): 86-88,142. doi: 10.3969/j.issn.1006-0111.2012.02.002
引用本文: 万展, 周剑, 韩美娜, 杨峰. 微针透皮给药系统应用研究进展[J]. 药学实践与服务, 2012, 30(2): 86-88,142. doi: 10.3969/j.issn.1006-0111.2012.02.002
shu
WAN Zhan, ZHOU Jian, HAN Mei-na, YANG Feng. Progress on micro-needles transdermal drug delivery system[J]. Journal of Pharmaceutical Practice and Service, 2012, 30(2): 86-88,142. doi: 10.3969/j.issn.1006-0111.2012.02.002
Citation: WAN Zhan, ZHOU Jian, HAN Mei-na, YANG Feng. Progress on micro-needles transdermal drug delivery system[J]. Journal of Pharmaceutical Practice and Service, 2012, 30(2): 86-88,142. doi: 10.3969/j.issn.1006-0111.2012.02.002
shu

微针透皮给药系统应用研究进展

doi: 10.3969/j.issn.1006-0111.2012.02.002
  • 1.

    河北北方学院基础医学院, 河北 张家口 075000;第二军医大学药学院, 上海 200433

  • 2.

    重庆医科大学药学院, 重庆 400331;第二军医大学药学院, 上海 200433

  • 3.

    第二军医大学药学院, 上海 200433

基金项目: 上海高校选拔培养优秀青年教师科研专项基金(egd09014).

Progress on micro-needles transdermal drug delivery system

  • 1.

    School of Basic Medical Sciences, Hebei North University, Zhangjiakou 075000, China;School of Pharmacy, Second Military Medical University, Shanghai 200433, China

  • 2.

    School of Pharmacy, Chongqing Medical University, Chongqing 400331, China;School of Pharmacy, Second Military Medical University, Shanghai 200433, China

  • 3.

    School of Pharmacy, Second Military Medical University, Shanghai 200433, China

  • 摘要: 微针透皮给药系统是近年来透皮给药系统研究的热点。微针透皮给药系统具有注射给药和透皮给药的双重优势,具有快速、方便、无痛等众多优点,研究表明可以显著提高药物透皮速率和吸收量,特别是在蛋白质、多肽、DNA和RNA等大分子物质的透皮制剂研究领域表现出良好的效果和应用前景,本文对微针透皮给药系统应用研究的最新进展进行了综述。随着微针加工技术、载药技术和应用研究的不断深入,微针透皮技术在临床领域将会有更广泛的应用。
    Abstract: Micro-needles transdermal drug delivery system became the hot spot in the field of transdermal drug delivery system, which had the double advantages in both injection drug delivery and transdermal drug delivery. It also had the merits of fast absorption, continence and painless utility in clinical. Research indicated both transdermal speed and dose of drugs were highly increased when micro-needles transdermal drug delivery system was applied, which especially showed outstanding effects and promise in the preparation of drugs composed of protein, polypeptide, DNA and RNA, etc. Latest developments of micro-needles transdermal drug delivery system were reviewed in this paper. With the development of the industrial arts of the micro-needle, drug delivery technology and application research, micro-needles transdermal drug delivery system would be extensively employed in clinical field.
  • [1] Henry S, McAllister DV, Allen MG, et al. Microfabricated microneedles : a novel approach to transdermal drug delivery[J]. J Pharmacol Sci,1998,87(8):922.
    [2] Mark RP, Robert L. Transdermal drug delivery[J].Nat Biotechnol,2008,26(11):1261.
    [3] Kalluri H, Banga AK. Transdermal delivery of proteins[J]. AAPS Pharmscitech, 2011.12(1):431.
    [4] Zhu QY,Zarnitsyn VG,Ye L,et al.Immunization by vaccine-coated microneedle arrays protects against lethal influenza virus challenge[J].Proc Natl Acad Sci USA,2009,106(19):7968.
    [5] Kaushik S, Hord AH, Denson DD, et al. Lack of pain associated with microfabricated microneedles[J]. Anesth.Analg,2001,92(2):502.
    [6] Ding Z,Riet V,Romeijn S,et al.Immune modulation by adjuvants combined with diphtheria toxoid administered topically in BALB／c mice after microneedle array pretreatment [J].Pharm Res,2009,26(7):163.
    [7] Sullivan SP, Koutsonanos DG,Del Pilar Martin M, et al.Dissolving polymer microneedle patches for influenza vaccination[J].Nat Med,2010,16(8):915.
    [8] Quan FS,Kim YC, Compans RW,et al. Dose sparing enabled by skin immunization with influenza virus-like particle vaccine using microneedles[J].J Controlled Release,2010,147(3):326.
    [9] Hiraishi Y,Nandakumar S,Choi SO,et al.Bacillus Calmette-Guerin vaccination using a microneedle patch[J].Vaccine,2011,29(14):2626.
    [10] Nordquist L,Roxhed N,Griss P,et al.ovel microneedle patches for active insulin delivery are efficientin maintaining glycaemic control:an initial comparison with ubcutaneous administration[J].Pharm Res,2007,24(7):1381.
    [11] Chen HB, Zhu HD,Zheng JN,et al. Iontophoresis-driven penetration of nanovesicles through microneedle induced skin microchannels for enhancing transdermal delivery of insulin[J]. J Controlled Release,2009,139(1):63.
    [12] Gupta J,Felner EI,Prausnitz MR.Rapid pharmacokinetics of intradermal insulin administered using microneedles in type 1 diabetes subjects[J].Diabetes Technol Ther,2011 13(4):451.
    [13] You X,Chang Jong-hyeon,Ju Byeong-Kwon,et al.Rapidly dissolving fibroin microneedles for transdermal drug delivery[J]. Mater Sci Eng.,C 2011,31(8):1632.
    [14] Qin G, Gao Y, Wu Y,et al.Simultaneous basal-bolus delivery of fast-acting insulin and its significance in diabetes management[J].Nanomedicine:NBM 2011,doi: 10.1016/j.nano.2011.05.017.
    [15] Harvey AJ,Kaestner SA,Sutter DE,et al.Microneedle-based intradermal delivery enables rapid lymphatic uptake and distribution of protein drugs[J].Pharm Res,2011,28(1):107.
    [16] Pearton M, Allender C, Brain K,et al.Gene delivery to the epidermal cells of human skin explants using microfabricated microneedles and hydrogel formulations[J]. Pharm Res,2008,25(2):407.
    [17] Gill HS, Soderholm J,Prausnitz MR,et al.Cutaneous vaccination using microneedles coated with hepatitis C DNA vaccine[J]. Gene Ther,2010,17(6):811.
    [18] Chen X,Kask AS,Crichton ML,et al.Improved DNA vaccination by skin-targeted delivery using dry-coated densely-packed microprojection arrays[J].J Controlled Release,2010,148(3):321.
    [19] Kask AS,Chen X,Marshak JO,et al.DNA vaccine delivery by densely-packed and short microprojection arrays to skin protects against vaginal HSV-2 challenge[J].Vaccine,2010,28(47):7483.
    [20] Gonzalez-Gonzalez E, Speaker TJ,Hickerson RP,et al.Silencing of reporter gene expression in skin using siRNAs and Expression of plasmid DNA delivered by a soluble protrusion array device[J]. Mol Ther,2010,18(9):1667.
    [21] Donnelly RF,Morrow DI,Fay F,et al.Microneedle-mediated intradermal nanoparticle delivery:potential for enhanced local administration of hydrophobic pre-formed photosensitisers[J].Photodiagnosis Photodyn Ther,2010,7(4):222.
    [22] Ito Y,Murano H,Hamasaki N,et al.Incidence of low bioavailability of leuprolide acetate after percutaneous administration to rats by dissolving microneedles[J].Int J Pharm,2011,407(1-2):126.
    [23] Baek C,Han M,Min J,et al.Local transdermal delivery of phenylephine to the anal sphincter muscle using microneedles[J].J Controlled Release,2011,154(2):138.
    [24] Milewski M,Yerramreddy TR,Ghosh P,et al.In vitro permeation of apegylated naltrexone prodrug across microneedle-treated skin[J].J Controlled Release,2010,146(1):37.
  • [1] 张艺昕, 关欣怡, 王博宁, 闻俊, 洪战英.  二氢吡啶类钙离子拮抗药物手性分析及其立体选择性药动学研究进展 . 药学实践与服务, 2024, 42(8): 319-324. doi: 10.12206/j.issn.2097-2024.202308062
    [2] 崔亚玲, 吴琼, 马良煜, 胡北, 姚东, 许子华.  肝素钠肌醇烟酸酯乳膏中肌醇烟酸酯皮肤药动学研究 . 药学实践与服务, 2024, 42(): 1-5. doi: 10.12206/j.issn.2097-2024.202404006
    [3] 陈炳辰, 佟达丰, 万苗, 闫飞虎, 姚建忠.  UPLC-MS/MS法测定小鼠血浆中紫杉醇脂肪酸酯前药及其药代动力学研究 . 药学实践与服务, 2024, 42(8): 341-345. doi: 10.12206/j.issn.2097-2024.202404082
    [4] 张莲卿, 骆岩, 杨提, 姚佳晨, 李文艳.  基于FAERS数据库的艾塞那肽微球不良事件信号挖掘与研究 . 药学实践与服务, 2024, 42(10): 445-450. doi: 10.12206/j.issn.2097-2024.202403057
    [5] 张广雨, 杜晶, 刘梦珍, 朱丹妮, 闫慧, 刘冲.  新斯的明与山莨菪碱联合应用对肺型氧中毒的保护作用及其机制的研究 . 药学实践与服务, 2024, 42(10): 433-438, 444. doi: 10.12206/j.issn.2097-2024.202310049
    [6] 刘依秦, 王超群, 邱娇娜.  胆宁片预处理在糖尿病患者结肠镜检查前的应用效果分析 . 药学实践与服务, 2024, 42(9): 407-410. doi: 10.12206/j.issn.2097-2024.202407037
    [7] 王晓飞, 张颖, 顾佳钰, 胡馨儿, 张海, 曹岩.  表面等离子共振传感器的识别元件在医药领域中的研究应用进展 . 药学实践与服务, 2024, 42(): 1-9. doi: 10.12206/j.issn.2097-2024.202309014
    [8] 丁千雪, 尚圣兰, 余梦辰, 余爱荣.  机器学习在肾病综合征患者他克莫司个体化用药中的应用 . 药学实践与服务, 2024, 42(6): 227-230, 243. doi: 10.12206/j.issn.2097-2024.202310007
    [9] 杨凤艳, 张月, 陈恩贤, 缪雪蓉, 魏凯.  瑞马唑仑临床应用研究进展 . 药学实践与服务, 2024, 42(9): 365-374. doi: 10.12206/j.issn.2097-2024.202405026
  • 加载中
WeChat 点击查看大图
计量
  • 文章访问数:  5363
  • HTML全文浏览量:  302
  • PDF下载量:  1245
  • 被引次数: 0
出版历程
  • 收稿日期:  2011-09-01
  • 修回日期:  2011-12-06

微针透皮给药系统应用研究进展

doi: 10.3969/j.issn.1006-0111.2012.02.002
  • 1. 河北北方学院基础医学院, 河北 张家口 075000;第二军医大学药学院, 上海 200433
  • 2. 重庆医科大学药学院, 重庆 400331;第二军医大学药学院, 上海 200433
  • 3. 第二军医大学药学院, 上海 200433
    • 基金项目:  上海高校选拔培养优秀青年教师科研专项基金(egd09014).
  • 收稿日期: 2011-09-01
  • 修回日期: 2011-12-06

摘要: 微针透皮给药系统是近年来透皮给药系统研究的热点。微针透皮给药系统具有注射给药和透皮给药的双重优势,具有快速、方便、无痛等众多优点,研究表明可以显著提高药物透皮速率和吸收量,特别是在蛋白质、多肽、DNA和RNA等大分子物质的透皮制剂研究领域表现出良好的效果和应用前景,本文对微针透皮给药系统应用研究的最新进展进行了综述。随着微针加工技术、载药技术和应用研究的不断深入,微针透皮技术在临床领域将会有更广泛的应用。

English Abstract

万展, 周剑, 韩美娜, 杨峰. 微针透皮给药系统应用研究进展[J]. 药学实践与服务, 2012, 30(2): 86-88,142. doi: 10.3969/j.issn.1006-0111.2012.02.002
引用本文: 万展, 周剑, 韩美娜, 杨峰. 微针透皮给药系统应用研究进展[J]. 药学实践与服务, 2012, 30(2): 86-88,142. doi: 10.3969/j.issn.1006-0111.2012.02.002
shu
WAN Zhan, ZHOU Jian, HAN Mei-na, YANG Feng. Progress on micro-needles transdermal drug delivery system[J]. Journal of Pharmaceutical Practice and Service, 2012, 30(2): 86-88,142. doi: 10.3969/j.issn.1006-0111.2012.02.002
Citation: WAN Zhan, ZHOU Jian, HAN Mei-na, YANG Feng. Progress on micro-needles transdermal drug delivery system[J]. Journal of Pharmaceutical Practice and Service, 2012, 30(2): 86-88,142. doi: 10.3969/j.issn.1006-0111.2012.02.002
shu

    全文HTML

参考文献 (24)

目录

    /

    返回文章
    返回

    版权所有：《药学实践与服务》编辑委员会

    主管、主办: 中国人民解放军海军军医大学地址: 上海市杨浦区国和路325号邮政编码: 200433

    电话: （021）81871324,81871397 E-mail: yxsjzzs@163.com

    网站备案号 沪ICP备05003363号-1

    本系统由 北京仁和汇智信息技术有限公司 开发    百度统计