葡萄糖氯化钠钾注射液与注射用盐酸头孢吡肟配伍的稳定性
Compatible stability of glucose and sodium potassium chloride injection mixing with cefepime Hydrochloride for injection
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摘要: 目的: 研究在室温下葡萄糖氯化钠钾注射液(简称GNK)与注射用盐酸头孢吡肟配伍后的稳定性。 方法: 采用RP-HPLC法测定配伍后注射用盐酸头孢吡肟的含量变化,同时考察配伍溶液的外观、pH值和不溶性微粒的变化。 结果: 在室温下配伍溶液8 h内均无气体或沉淀产生,pH值、不溶性微粒和含量均无明显变化。 结论: GNK与注射用盐酸头孢吡肟配伍后8 h稳定,在8 h内可安全应用于临床。
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关键词:
- 配伍稳定性 /
- 葡萄糖氯化钠钾注射液 /
- 盐酸头孢吡肟
Abstract: Objective To study the stability of glucose and sodium potassium chloride injection(GNK) mixing with cefepime hydrochloride in room temperature. Methods RP-HPLC was applied to determine the content change of cefepime hydrochloride in different time.The pH,quantity of non-soluble particulate and appearance of mixtures were also observed. Results In room temperature the mixtures produced neither gas nor sediment.The pH,quantity of non-soluble particulate and content did not change within 8 hours. Conclusion The mixtures of GNK mixing with cefepime hydrochloride are stable in 8 hours.-
Key words:
- compatible stability /
- GNK /
- cefepime hydrochloride
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