不同分子量构成的玻璃酸钠对骨关节炎治疗作用的实验研究
Experimental study of therapeutic effects on osteoarthritis with sodium hyaluronate of different molecular weight
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摘要: 目的观察不同分子量构成(分子量150万Da以上相对大分子和150万Da以下相对小分子)的玻璃酸钠对骨关节炎治疗作用的特点。方法采用骨关节固定法和木瓜蛋白酶关节腔内注射两种方法造成兔膝骨关节炎模型,采用病理学研究以及镇痛实验和毛细血管通透性实验评价两种不同分子量玻璃酸钠对骨关节炎的治疗效果。结果两种玻璃酸钠对骨关节炎模型关节软骨和滑膜的病变均有不同程度的治疗作用,均能有效镇痛,并抑制毛细血管通透性。在木瓜蛋白酶注射法制作的兔膝骨关节炎模型中,分子量为150万Da以下的相对小分子量玻璃酸钠组在促进软骨组织修复和减少滑膜组织增生方面治疗效果更好。结论本研究选用的不同分子量玻璃酸钠在治疗骨关节炎方面均有确切疗效,显示玻璃酸钠治疗骨关节炎安全有效,而分子量为80~150万Da的相对小分子量玻璃酸钠在促进软骨组织修复和减少滑膜组织增生方面略显优势。Abstract: Objective To study the therapeutic effects of sodium hyaluronate injection of different molecular weight(MW: 800~1500 kDa vs.1500~2500 kDa) on osteoarthritis. Methods Two kinds of osteoarthritis models were induced in rabbit’s knee joints: long-term immobilization experiment,and intra-articular injection of papain.Pathological study,analgesic effect experiment and capillary permeability experiment were carried out to observe the effects of treatment with intra-articular injection of sodium hyaluronate. Results Both of the two kinds of sodium hyaluronate injection of different molecular weight have the ability to resist the pathological changes of cartilage and synovial.They all show significant analgesic effect and inhibit capillary permeability.Furthermore,greater improvement in osteoarthritis models induced by intra-articular injection of papain was achieved by administration of sodium hyaluronate of relatively low molecular weight(MW: 800~1500 kDa). Conclusion Sodium hyaluronate of different molecular weight all could improve the outcomes of osteoarthritis.Our findings suggest that sodium hyaluronate treatment of osteoarthritis is a safe,effective therapeutic option,and low molecular weight sodium hyaluronate may have better performance in improving the pathological changes of cartilage and synovial.
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Key words:
- osteoarthritis /
- sodium hyaluronate /
- molecular weight
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