注射用氨苄西林钠/氯唑西林钠与不同溶媒配伍稳定性的研究
Study on compatible stability of ampicloxacillin sodium for injection in five infusions
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摘要: 目的 :研究注射用氨苄西林钠/氯唑西林钠(氨氯青霉素钠)与5种常用输液在不同放置时间、不同温度下的配伍稳定性。 方法 :将注射用氨苄西林钠/氯唑西林钠用5种常用输液分别配成溶液,用高效液相色谱法测定各配伍液中氨苄西林钠、氯唑西林钠的含量。 结果 :样品与5%葡萄糖注射液和葡萄糖氯化钠注射液配伍时,随着放置时间和温度的升高,各组溶液中氨苄西林钠和氯唑西林钠的含量下降,其中以葡萄糖注射液中者最为显著。 结论 :氨氯青霉素钠在5%葡萄糖和葡萄糖氯化钠注射液中不稳定。Abstract: Objective : To investigate the compatible stability of ampicoxacillin sodium for injection in five infusions in different time and different temperature conditions. Methods : Ampicloxacillin sodium was dissolved in five infusions.Ampicillin and cloxacillin in ampicloxacillin sodium for injection were determined by HPLC,and the color changes of all infusions were observed. Results : The ampicillin and eloxacillin contents in ampicloxacillin sodium for injection declined with time and temperature increased.The most distinct were 5% glucose injection. Concision : Ampicloxacillin sodium for injection wasn't stable in 5% glucose, gluscose and sodium chloride injection.
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Key words:
- ampicloxacillin /
- ampicillin /
- cloxacillin /
- compatibility
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