灰指灵药膏皮肤毒性及过敏性试验观察
The observation toxicity and hypersensitive test of Hueizhilin ointment to skin
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摘要: 目的 评价灰指灵(主含间苯二酚、升华硫、水杨酸等)药膏的皮肤安全性。方法 常规急性毒性试验和皮肤刺激性试验。结果 灰指灵药膏对大鼠完整皮肤,破损皮肤均无急性毒性反应,也不影响伤口愈合,对大鼠亦无长期皮肤毒性反应。对豚鼠皮肤一次和多次涂药均有刺激性,均属中度刺激性。对豚鼠未产生皮肤过敏反应。结论 本制剂无毒性,可供甲真菌病、手足癣、患者使用。Abstract: OBJECTIVE To evaluate safety for skin of Hueizhilin ointment which containes resorcinol,sulfur, salicylic acid,et al. METHODS Acute toxicity test and skin hypersensitive test were used. RESULTS Hueizhilin oitment had no acute toxicity and chronic toxicity to rat skin. But It had middle irritation to rat skin. No hypersensitive reaction be taken place during treatment. CONCLUSION Hueizhilin ointment has no toxicity to the skin. It can be used in patients with onychomycosis, tinea manus and pedis.
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Key words:
- Hueizhilin /
- tpxicity /
- irritation /
- hypersensilivity
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