黄芪保心汤对急性心肌缺血大鼠血浆ET、CGRP水平的影响

李小宁; 卫新国; 尚云; 卫洪昌; 朱晓梅; 孙平龙; 严世芸

留言板

尊敬的读者、作者、审稿人, 关于本刊的投稿、审稿、编辑和出版的任何问题, 您可以本页添加留言。我们将尽快给您答复。谢谢您的支持!

姓名
邮箱
手机号码
标题
留言内容
验证码

x 关闭永久关闭

重要提示

《药学实践与服务》杂志不接收生物战剂、毒剂相关内容的稿件。对于涉军信息类论文如需投稿，请务必投稿前电话或邮箱咨询。联系电话：021-81871323，邮箱：yxsjzzs@163.com。敬请谅解，谢谢配合！

《药学实践与服务》编辑部

免责声明

《药学实践与服务》杂志目前不收取审稿费、版面费、加急费等费用，如收到邮件声称是编辑部X编辑，要求加作者微信的，请谨防财产损失！编辑部用于作者校稿时微信绑定的邮件是通过yxsjzzs@163.com发送的，标题是《药学实践与服务》XML数字出版服务微信绑定，请区分开！

黄芪保心汤对急性心肌缺血大鼠血浆ET、CGRP水平的影响

李小宁, 卫新国, 尚云, 卫洪昌, 朱晓梅, 孙平龙, 严世芸

文章导航 > 药学实践与服务 > 2001 > (5): 270-272

李小宁, 卫新国, 尚云, 卫洪昌, 朱晓梅, 孙平龙, 严世芸. 黄芪保心汤对急性心肌缺血大鼠血浆ET、CGRP水平的影响[J]. 药学实践与服务, 2001, (5): 270-272.

引用本文:

李小宁, 卫新国, 尚云, 卫洪昌, 朱晓梅, 孙平龙, 严世芸. 黄芪保心汤对急性心肌缺血大鼠血浆ET、CGRP水平的影响[J]. 药学实践与服务, 2001, (5): 270-272.

LI Xiao-ning, WEI Xin-guo, SHANG Yun, WEI Hong-chang, ZHU Xiao-mei, SUN Ping-long, YAN Shi-yun. Influence of Astragalus heart keeping decoction on plasma ET and CGRP in the rats of experimental acute myocardial infarction[J]. Journal of Pharmaceutical Practice and Service, 2001, (5): 270-272.

Citation:

LI Xiao-ning, WEI Xin-guo, SHANG Yun, WEI Hong-chang, ZHU Xiao-mei, SUN Ping-long, YAN Shi-yun. Influence of Astragalus heart keeping decoction on plasma ET and CGRP in the rats of experimental acute myocardial infarction[J]. Journal of Pharmaceutical Practice and Service, 2001, (5): 270-272.

黄芪保心汤对急性心肌缺血大鼠血浆ET、CGRP水平的影响

1.
上海市南汇县光明中医医院, 上海201300
2.
上海中医药大学, 上海200032

Influence of Astragalus heart keeping decoction on plasma ET and CGRP in the rats of experimental acute myocardial infarction

1.
Guangming Hospital of TCM, Nanhui, Shanghai 201300, China
2.
Shanghai University of Traditional Chinese Medicine and Pharmacy, Shanghai 200032, China

摘要: 目的探讨黄芪保心汤地实验性急性心肌缺血大鼠血浆内皮素(ET)、降钙素基因相关肽(CGRP)水平的影响。方法 44只大白鼠随机分为4组:假手术组,模型对照组,黄芪保心汤组,复方丹参滴丸组。结扎左冠状动脉前降支造成急性心肌缺血模型,观察3h后,从腹主动脉取血检测血浆ET、CGRP水平。结果黄芪保心汤组,能显着降低血浆ET含量(P<0.001),升高血浆GGRP水平(P<0.01)。结论以益气活血祛痰化浊为主的黄芪保心汤有调节急性心肌缺血时血浆ET、CGRP水平失衡的作用,改善心肌缺血、缺氧状态,减少心肌缺血损伤,且作用优于复方丹参滴丸。
- 急性实验性心肌缺血 /
- 内皮素 /
- 降钙素基因相关肽 /
- 黄芪保心汤
Abstract: OBJECTIVE To investigate the influence of Astragalus heart keeping decoction on the level of plasma endothelin(El') and calcitonin gene related peptide (CGRP) in rats during the coronary artery occlusion in vivo. METHODS 44 rats were devided randomly into the sham ligation group, the control group, the Astragalus heart -keeping decoction (AHKD) group, the Composite Danshen Droplet Pills (CDDP) group. Various groups of the rats were fed with water, AHKD, CDDP for four weeks, respectively. And then rats were subjected to left anterior descending artery occlusion for 3 hour. for the determination of plasma El' and CGRP. RESULTS the level of plasma ET was lower on average in the group of AHKD than in the control group(P<0.01),and in comparison with the control group there was no significant difference in plasma ET in the group of CDDP (P<0.05). The level of plasma CGRP in the AHKD and CDDP groups was higher than that of plasma CGRP in the control group (P<0.01). CONCLUSION AHKD and CDDP have the function to regulate the level of plasma ET and CGRP in rats during the coronary artery occlusion, to improve myocardial ischemia,and that the efficacy of AHKD is superior to that of CDDP.
- astragalus heart-keeping decoction /
- acute myocardial infarction /
- experimental study /
- ET

[1]	张紫璇, 高苑, 张利, 李佳莉, 徐希科, 祖先鹏. 中药防治急性肺损伤的活性成分及其作用机制研究进展 . 药学实践与服务, 2025, 43(9): 421-426, 474. doi: 10.12206/j.issn.2097-2024.202404079
[2]	何静, 安晔, 张朝绅. 复方黑参滴丸与复方黑参丸药效学实验比较研究 . 药学实践与服务, 2025, 43(1): 17-21. doi: 10.12206/j.issn.2097-2024.202404009
[3]	赵凤平, 于镇铭, 陈熹, 姜棋文, 郑灿辉, 陈新. 醛脱氢酶2改善铁死亡相关疾病预后的研究进展 . 药学实践与服务, 2025, 43(): 1-7. doi: 10.12206/j.issn.2097-2024.202411043
[4]	杨瑾冬, 房振西, 聂成洋, 陈瑞兵, 李卿, 张磊. 丹参及其近缘物种的叶绿体基因组分析 . 药学实践与服务, 2025, 43(6): 275-282. doi: 10.12206/j.issn.2097-2024.202504023
[5]	冯婷婷, 张景翔, 王彦, 许维恒, 张俊平. ANXA3基因及蛋白的研究进展 . 药学实践与服务, 2025, 43(2): 47-50, 74. doi: 10.12206/j.issn.2097-2024.202309023
[6]	赵雪, 顾妍秋, 楚皓文, 吴彩胜, 李镐, 陈啸飞. 基于超高效液相色谱-四极杆飞行时间质谱的麻杏石甘汤化学成分分析 . 药学实践与服务, 2025, 43(11): 548-554, 571. doi: 10.12206/j.issn.2097-2024.202306028
[7]	张霖峰, 孙宇恒, 王冬尧, 李丹, 曹岩, 吕狄亚. 茵陈蒿汤体内成分分析及其抗肝癌作用机制的网络药理学研究 . 药学实践与服务, 2025, 43(): 1-9. doi: 10.12206/j.issn.2097-2024.202501017
[8]	段雅倩, 王旭, 唐高卿, 邵艳茹, 黄宝康. 莲子和莲子心生物碱成分及抗癌活性的比较分析 . 药学实践与服务, 2025, 43(9): 449-454. doi: 10.12206/j.issn.2097-2024.202407061
[9]	赵全公, 王国坤, 徐志云. 虾青素通过激活Nrf2/HO-1通路抑制瓣膜间质细胞钙化 . 药学实践与服务, 2025, 43(6): 283-287. doi: 10.12206/j.issn.2097-2024.202412057
[10]	吴若南, 叶爽, 李墨晨轩, 缪震元, 罗川. 冬凌草甲素磺酰脲衍生物的设计与抗炎活性研究 . 药学实践与服务, 2025, 43(7): 335-338, 352. doi: 10.12206/j.issn.2097-2024.202401048
[11]	竺东杰, 贺新征, 邹杰, 余史丹, 李红霞. 雷公藤甲素对大鼠脑缺血再灌注损伤的影响及机制研究 . 药学实践与服务, 2025, 43(7): 339-343, 361. doi: 10.12206/j.issn.2097-2024.202311021
[12]	王鹏, 张争艳, 吴宗贵. 活心丸（浓缩丸）联合八段锦对急性心肌梗死合并心力衰竭介入术预后的影响 . 药学实践与服务, 2025, 43(7): 348-352. doi: 10.12206/j.issn.2097-2024.202308034
[13]	姚瑞阳, 于海征, 李耀盺, 张磊. 丹参FBXL 基因家族的鉴定和表达模式分析 . 药学实践与服务, 2024, 42(11): 461-470. doi: 10.12206/j.issn.2097-2024.202407034
[14]	岳春华, 贲永光, 王海桥. 基于NLRP1炎症小体探讨百合知母汤抗抑郁的作用机制 . 药学实践与服务, 2024, 42(8): 325-333. doi: 10.12206/j.issn.2097-2024.202401033
[15]	张莲卿, 骆岩, 杨提, 姚佳晨, 李文艳. 基于FAERS数据库的艾塞那肽微球不良事件信号挖掘与研究 . 药学实践与服务, 2024, 42(10): 445-450. doi: 10.12206/j.issn.2097-2024.202403057
[16]	景凯, 杨慈荣, 张圳, 臧艺蓓, 刘霞. 黄芪甲苷衍生物治疗慢性心力衰竭小鼠的药效评价及作用机制研究 . 药学实践与服务, 2024, 42(5): 190-197. doi: 10.12206/j.issn.2097-2024.202310004
[17]	何亚伦, 祁智, 常杰. 消胀通便膏在晚期肝癌患者阿片类药物相关性便秘中的应用研究 . 药学实践与服务, 2024, 42(12): 520-523. doi: 10.12206/j.issn.2097-2024.202309009
[18]	孙丹倪, 黄勇, 张嘉宝, 王培. 代谢相关脂肪性肝病的无创诊断与药物治疗 . 药学实践与服务, 2024, 42(10): 411-418. doi: 10.12206/j.issn.2097-2024.202403049
[19]	唐淑慧, 凤美娟, 薛智霞, 鲁桂华. 帕博利珠单抗治疗所致免疫相关不良反应与中医体质的相关性研究 . 药学实践与服务, 2024, 42(5): 217-222. doi: 10.12206/j.issn.2097-2024.202311029
[20]	桂明珠, 李静, 李志玲. 儿童伏立康唑的血药浓度与CYP2C19、CYP2C9和CYP3A5基因多态性的相关性研究 . 药学实践与服务, 2024, 42(): 1-5. doi: 10.12206/j.issn.2097-2024.202402020

点击查看大图

计量

文章访问数: 3673
HTML全文浏览量: 263
PDF下载量: 392
被引次数: 0

黄芪保心汤对急性心肌缺血大鼠血浆ET、CGRP水平的影响

1. 上海市南汇县光明中医医院, 上海201300

2. 上海中医药大学, 上海200032

收稿日期: 2001-04-24

关键词:

急性实验性心肌缺血 /

内皮素 /

降钙素基因相关肽 /

黄芪保心汤

摘要: 目的探讨黄芪保心汤地实验性急性心肌缺血大鼠血浆内皮素(ET)、降钙素基因相关肽(CGRP)水平的影响。方法 44只大白鼠随机分为4组:假手术组,模型对照组,黄芪保心汤组,复方丹参滴丸组。结扎左冠状动脉前降支造成急性心肌缺血模型,观察3h后,从腹主动脉取血检测血浆ET、CGRP水平。结果黄芪保心汤组,能显着降低血浆ET含量(P<0.001),升高血浆GGRP水平(P<0.01)。结论以益气活血祛痰化浊为主的黄芪保心汤有调节急性心肌缺血时血浆ET、CGRP水平失衡的作用,改善心肌缺血、缺氧状态,减少心肌缺血损伤,且作用优于复方丹参滴丸。

English Abstract

Influence of Astragalus heart keeping decoction on plasma ET and CGRP in the rats of experimental acute myocardial infarction

1. Guangming Hospital of TCM, Nanhui, Shanghai 201300, China

2. Shanghai University of Traditional Chinese Medicine and Pharmacy, Shanghai 200032, China

Received Date: 2001-04-24

Keywords:

Abstract: OBJECTIVE To investigate the influence of Astragalus heart keeping decoction on the level of plasma endothelin(El') and calcitonin gene related peptide (CGRP) in rats during the coronary artery occlusion in vivo. METHODS 44 rats were devided randomly into the sham ligation group, the control group, the Astragalus heart -keeping decoction (AHKD) group, the Composite Danshen Droplet Pills (CDDP) group. Various groups of the rats were fed with water, AHKD, CDDP for four weeks, respectively. And then rats were subjected to left anterior descending artery occlusion for 3 hour. for the determination of plasma El' and CGRP. RESULTS the level of plasma ET was lower on average in the group of AHKD than in the control group(P<0.01),and in comparison with the control group there was no significant difference in plasma ET in the group of CDDP (P<0.05). The level of plasma CGRP in the AHKD and CDDP groups was higher than that of plasma CGRP in the control group (P<0.01). CONCLUSION AHKD and CDDP have the function to regulate the level of plasma ET and CGRP in rats during the coronary artery occlusion, to improve myocardial ischemia,and that the efficacy of AHKD is superior to that of CDDP.

李小宁, 卫新国, 尚云, 卫洪昌, 朱晓梅, 孙平龙, 严世芸. 黄芪保心汤对急性心肌缺血大鼠血浆ET、CGRP水平的影响[J]. 药学实践与服务, 2001, (5): 270-272.

引用本文:

李小宁, 卫新国, 尚云, 卫洪昌, 朱晓梅, 孙平龙, 严世芸. 黄芪保心汤对急性心肌缺血大鼠血浆ET、CGRP水平的影响[J]. 药学实践与服务, 2001, (5): 270-272.

Citation:

LI Xiao-ning, WEI Xin-guo, SHANG Yun, WEI Hong-chang, ZHU Xiao-mei, SUN Ping-long, YAN Shi-yun. Influence of Astragalus heart keeping decoction on plasma ET and CGRP in the rats of experimental acute myocardial infarction[J]. Journal of Pharmaceutical Practice and Service, 2001, (5): 270-272.

全文HTML

下载: 全尺寸图片幻灯片

返回文章

用微信扫码二维码

分享至好友和朋友圈

主管、主办: 中国人民解放军海军军医大学地址: 上海市杨浦区国和路325号邮政编码: 200433

电话: （021）81871324,81871397 E-mail: yxsjzzs@163.com

网站备案号沪ICP备05003363号-1

本系统由北京仁和汇智信息技术有限公司开发

留言板

黄芪保心汤对急性心肌缺血大鼠血浆ET、CGRP水平的影响

Influence of Astragalus heart keeping decoction on plasma ET and CGRP in the rats of experimental acute myocardial infarction

计量

出版历程

黄芪保心汤对急性心肌缺血大鼠血浆ET、CGRP水平的影响

1. 上海市南汇县光明中医医院, 上海201300 2. 上海中医药大学, 上海200032

English Abstract

Influence of Astragalus heart keeping decoction on plasma ET and CGRP in the rats of experimental acute myocardial infarction

1. Guangming Hospital of TCM, Nanhui, Shanghai 201300, China 2. Shanghai University of Traditional Chinese Medicine and Pharmacy, Shanghai 200032, China

全文HTML

目录

1. 上海市南汇县光明中医医院, 上海201300

2. 上海中医药大学, 上海200032

1. Guangming Hospital of TCM, Nanhui, Shanghai 201300, China

2. Shanghai University of Traditional Chinese Medicine and Pharmacy, Shanghai 200032, China