Clinical observation on local reaction of the subcutaneous etanercept for treating ankylosing spondylitis with different injection site
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摘要: 目的 观察不同部位注射益赛普治疗强直性脊柱炎局部皮肤反应。 方法 选取2012年3月-2013年3月在该院住院治疗的强直性脊柱炎患者60例。随机分为A、B两组,每组30例。A组采用上臂三角肌皮下注射,B组采用腹部皮下注射,比较两组患者发生皮肤局部不良反应情况。 结果 上臂三角肌皮下注射的A组患者发生不良反应为10例,经腹部皮下注射的B组患者发生不良反应为1例,腹部皮下注射不良反应发生率明显低于上臂三角肌皮下注射(P<0.05)。 结论 腹部皮下注射益赛普治疗强直性脊柱炎可以减少局部皮肤的不良反应,提高临床疗效,值得推广应用。Abstract: Objective To observe adverse reactions of the subcutaneous etanercept with different injection site. Methods 60 patients with ankylosing spondylitis treated in our hospital from March 2012 to March 2013 were divided randomly into two groups.A group were injected deltoid subcutaneous,and B group were injected abdominal subcutaneous.The local adverse skin reactions were compared between the two groups. Results 10 cases occurred adverse reactions from A group,and only 1case occurred adverse reactions from group B.The incidence of adverse reactions of injected subcutaneously significantly lower than deltoid subcutaneous (P<0.05). Conclusion Abdominal subcutaneous etanercept could reduces the incidence of adverse reactions,which was worthy of clinical application.
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Key words:
- etanercept /
- subcutaneously /
- adverse reaction
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[1] 汪年松,冯承德.风湿病学[M].上海:上海交通大学出版社,2009:234-237. [2] Breedveld FC.Tumour necrosis factor antagonists:infliximab,adalimumab and etanercept[J].Ned Tijdschr Geneeskd,2005,149(41):2273-2277. [3] Clelland S,Hunek JR.Etanercept injection site reaction[J].Dermatol Nurs,2005,17(5):375. -
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