沙利度胺联合地塞米松治疗老年多发性骨髓瘤的疗效分析及不良反应

吴宁宁

doi:10.3969/j.issn.1006-0111.2012.06.014

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沙利度胺联合地塞米松治疗老年多发性骨髓瘤的疗效分析及不良反应

吴宁宁

文章导航 > 药学实践与服务 > 2012 > 30(6): 447-448

吴宁宁. 沙利度胺联合地塞米松治疗老年多发性骨髓瘤的疗效分析及不良反应[J]. 药学实践与服务, 2012, 30(6): 447-448. doi: 10.3969/j.issn.1006-0111.2012.06.014

引用本文:

吴宁宁. 沙利度胺联合地塞米松治疗老年多发性骨髓瘤的疗效分析及不良反应[J]. 药学实践与服务, 2012, 30(6): 447-448. doi: 10.3969/j.issn.1006-0111.2012.06.014

WU Ning-ning. Therapeutic effect and adverse reaction of Thalidomide combined with dexamethasone in elderly patients with multiple myeloma[J]. Journal of Pharmaceutical Practice and Service, 2012, 30(6): 447-448. doi: 10.3969/j.issn.1006-0111.2012.06.014

Citation:

WU Ning-ning. Therapeutic effect and adverse reaction of Thalidomide combined with dexamethasone in elderly patients with multiple myeloma[J]. Journal of Pharmaceutical Practice and Service, 2012, 30(6): 447-448. doi: 10.3969/j.issn.1006-0111.2012.06.014

沙利度胺联合地塞米松治疗老年多发性骨髓瘤的疗效分析及不良反应

doi: 10.3969/j.issn.1006-0111.2012.06.014

吴宁宁

宁波市第二医院血液科, 浙江宁波 315000

Therapeutic effect and adverse reaction of Thalidomide combined with dexamethasone in elderly patients with multiple myeloma

WU Ning-ning

Department of Hematology, Second Hospital of Ningbo, Ningbo 315000, China

摘要: 目的观察沙利度胺联合地塞米松治疗老年多发性骨髓瘤的疗效和安全性。方法初治老年多发性骨髓瘤患者50例,均给予沙利度胺联合地塞米松治疗,沙利度胺起始剂量50 mg/次,1次/d,口服,根据患者耐受情况逐步增加剂量50 mg,至最大量200 mg/次,1次/日,口服;地塞米松20 mg/次,1次/日,第1~4天,第9~12天,第17~20天,静脉滴注,每28 d为1个疗程。治疗4个疗程后评定疗效。结果完全缓解15例,非常好的部分缓解12例,部分缓解13例,病情无变化5例,疾病进展5例,总有效率为80%。治疗过程中出现嗜睡l7例,便秘16例,疲乏16例,血糖升高10例,外周神经炎8例,皮疹3例,对症处理后均可耐受。结论沙利度胺联合地塞米松是治疗老年多发性骨髓瘤的有效方法。
- 沙利度胺 /
- 地塞米松 /
- 多发性骨髓瘤
Abstract: Objective To observe the efficiency and safety of thalidomide combined with dexamethasone in elderly patients with multiple myeloma. Methods A total of 50 elderly patients with multiple myeloma in initial treatment were administered thalidomide combined with dexamethasone. Thalidomide was administered at an initial dose of 50 mg once-daily orally followed by gradually increased in 50 mg according to patients' tolerance to a maximum of 200 mg once-daily orally, dexamethasone was administered at 20 mg once-daily IV in 1~4 d, 9~12 d and 17~20 d with 28 d as a course of treatment. The efficiency after 4 courses of treatment eva-luate was evauated. Results Complete remission were in 15 cases, immense partial remission in 12 cases, partial remission in 13 cases, no change in 5 cases and progression of disease in 5 cases. The total effective rate was 80%. During treatment, there were 17 patients suffering from hypersomnia, 16 onstipation, 16 lassitude, 10 increased blood sugar, 8 peripheral neuropathy and 3 rashes. All the patients could tolerant after expectant treatment. Conclusion It could be an effective method of thalidomide combined with dexamethasone in elderly patients with multiple myeloma.
- thalidomide /
- dexamethasone /
- multiple

[1]	沙信山,李永辉,张桂芳,等.小剂量沙利度胺联合长春地辛、吡喃阿霉素和地塞米松方案治疗老年多发性骨髓瘤[J].中华实用诊断与治疗杂志,2009,23(3):303.
[2]	中国多发性骨髓瘤工作组.中国多发性骨髓瘤诊治指南[J].中华内科杂志,2008,47(10):869.
[3]	Facon T, Mary JY, Pegourie B, et al. Dexamethasone-based regi-mens versus melphalan-prednisone for elderly multiple myeloma patients ineligible for high-dose therapy[J]. Blood,2006,107(4):1292.
[4]	Fujita J,Mestre JR,Zeldis JB,et al.Thalidomide and its analogues inhibit lipop1ysaccharide mediated linduction of cyclooxygenase 2[J].Clin Cancer Res,2001,7(11):3349.
[5]	顾惠慈.三氧化二砷联合化疗治疗难治复发多发骨髓瘤的临床疗效分析[J].实用诊断与治疗杂志,2006,20(12):918.
[6]	张之南.血液病诊断及疗效标准[M].第2版,北京:科学出版社,1998:73.

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沙利度胺联合地塞米松治疗老年多发性骨髓瘤的疗效分析及不良反应

doi: 10.3969/j.issn.1006-0111.2012.06.014

吴宁宁

宁波市第二医院血液科, 浙江宁波 315000

收稿日期: 2012-02-21
修回日期: 2012-05-28

关键词:

沙利度胺 /

地塞米松 /

多发性骨髓瘤

摘要: 目的观察沙利度胺联合地塞米松治疗老年多发性骨髓瘤的疗效和安全性。方法初治老年多发性骨髓瘤患者50例,均给予沙利度胺联合地塞米松治疗,沙利度胺起始剂量50 mg/次,1次/d,口服,根据患者耐受情况逐步增加剂量50 mg,至最大量200 mg/次,1次/日,口服;地塞米松20 mg/次,1次/日,第1~4天,第9~12天,第17~20天,静脉滴注,每28 d为1个疗程。治疗4个疗程后评定疗效。结果完全缓解15例,非常好的部分缓解12例,部分缓解13例,病情无变化5例,疾病进展5例,总有效率为80%。治疗过程中出现嗜睡l7例,便秘16例,疲乏16例,血糖升高10例,外周神经炎8例,皮疹3例,对症处理后均可耐受。结论沙利度胺联合地塞米松是治疗老年多发性骨髓瘤的有效方法。