益心酮抗心肌缺血作用的实验研究
Experimental study on anti-myocardial ischemia effect of Yixintong
-
摘要: 目的 研究益心酮的抗心肌缺血作用。 方法 采用腹腔注射异丙肾上腺素造成大鼠心肌缺血模型,运用益心酮治疗;采用皮下注射大剂量肾上腺素加寒冷刺激的方法复制大鼠急性血瘀模型,以观察益心酮对血瘀大鼠血黏度的影响;观察益心酮对大鼠血小板聚集率的影响;采用实验性急性心肌梗死犬模型,观察益心酮的抗心肌缺血作用。 结果 益心酮能够降低心肌缺血大鼠心电图中ST段位移,降低AST(天门冬氨酸氨基转移酶)、CPK(肌酸磷酸激酶)、LDH(乳酸脱氢酶)等心肌酶的升高程度,降低血液黏度;益心酮能够改善大鼠血瘀模型血液流变学,降低其血黏度;益心酮能够降低大鼠血小板聚集率;4益心酮能够降低心肌缺血程度(Σ-ST),减少心肌缺血范围(N-ST),缩小心肌梗死面积(MST),同时能够降低血清中AST、CPK和LDH等心肌酶的升高程度。 结论 益心酮具有抗心肌缺血作用。Abstract: Objective To study the anti-myocardial ischemia effect of Yixintong. Methods The rat myocardial ischemia model was caused by isoprenaline and the experiment myocardial infraction dogs were used to observe the effect of Yixintong. Blood stasis model was used to observe the effect of Yixintong on blood viscosity and platelet aggregation. Results Yixintong (0.4 g/kg, 0.2 g/kg)could decrease ST length and rise serum enzyme(such as AST,CPK and LDH). Yixintong (0.4 g/kg,0.2 g/kg) could also lower the blood viscosity. Yixintong could improve hemorrheologic abnormality and lower the whole blood viscosity. Yixintong could inhibit platelet aggregation of rat. Yixintong could ameliorate the myocardial ischemia degree(Σ-ST) and decrease the myocardial ischemia coverage(N-ST). Yixintong could also decrease the rised serum enzyme(such as AST,CPK and LDH). Conclusions Yixintong had a protective and therapeutic action to the experimental myocardial ischemia.
-
Key words:
- Yinxintong /
- myocardial ischemia /
- blood viscosity /
- platelet aggregation /
- myocardia enzyme
-
[1] 陈 修. 心血管药物和药理学研究进展与展望[J]. 中国药理学与毒理学杂志,1995,9(3):161. [2] 张玉玺,姚晓颖,肖 艳,等.大根草提取物对模型大鼠心肌缺血的保护作用研究[J].中国药房,2009,20(33):2575. [3] 朴晋华,董培智,高天红,等.益心酮片对大鼠心肌缺血的保护作用[J]. 中国中药杂志,2003,28(5):442. [4] 张钧田.现代药理实验方法学[M].北京:北京医科大学中国协和医科大学联合出版社,1989:1153. [5] 邱 全 ,王 辉 ,王海洋 ,等.水蛭颗粒对大鼠急性血瘀模型血液流变学、SOD、MDA的影响[J].实用中医药杂志,2008,24(11):687. [6] 徐叔云,卞如濂,陈 修. 药理实验方法学[M].第2版.北京:人民卫生出版社,1991:854. [7] 李路江 ,吴子芳 ,吕文伟,等.红花提取物对犬急性心肌缺血的保护作用[J].中草药,2007,37(9):1381. -
点击查看大图
计量
- 文章访问数: 2937
- HTML全文浏览量: 278
- PDF下载量: 178
- 被引次数: 0
下载:
