摘要:
目的: 观察镰形棘豆中2′,4′-二羟基查尔酮的抗炎和止血作用。 方法: 取2′,4′-二羟基查尔酮配成溶液,小鼠ig给药连续5 d,使用二甲苯致小鼠耳肿胀后,观察其抗炎作用;同样给药方式,采用断尾法测定出血时间、玻片法和毛细管法测定凝血时间、眼眶采血测定凝血酶原时间(PT);以此观察2′,4′-二羟基查尔酮的止血作用。 结果: 2′,4′-二羟基查尔酮能抑制二甲苯所致小鼠耳肿胀的肿胀度,其高剂量(80 mg/ml)对肿胀的抑制率接近地塞米松抑制率;2′,4′-二羟基查尔酮有缩短小鼠出血时间、加速凝血和缩短PT的作用,其中高剂量(80 mg/ml)作用更为明显。 结论: 镰形棘豆中2′,4′-二羟基查尔酮具有良好的抗炎、止血和促凝血作用。
Abstract:
Objective To observe the effect of anti-inflammatory and hemostasis of 2′,4′-dihydroxy chalcone in Oxyptropis Falcate Bunge. Methods the mice were taken 2′,4′-dihydroxy chalcone by gavage in 5 days.The anti-inflammatory effect was determined by using the model of xylene-induced mouse ear edema.The hemostasis effect was measured by bleeding time,clotting time and prothrombin time in mice. Results The compounds reduced the bleeding time,accelerated blood clotting and decreased the role of PT in mice,which was more obviously effective in high dose(80 mg/kg). Conclusion 2′,4′-dihydroxy chalcone in Oxyptropis Falcate Bunge has good effects on anti-inflammatory,hemostasis and blood coagulation.
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