锗对关节炎大鼠PGE<SUB>2</SUB>的影响

张哲; 郭苗莉; 郭俊生

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锗对关节炎大鼠PGE₂的影响

张哲, 郭苗莉, 郭俊生

文章导航 > 药学实践与服务 > 2009 > 27(3): 174-176

张哲, 郭苗莉, 郭俊生. 锗对关节炎大鼠PGE2的影响[J]. 药学实践与服务, 2009, 27(3): 174-176.

引用本文:

张哲, 郭苗莉, 郭俊生. 锗对关节炎大鼠PGE₂的影响[J]. 药学实践与服务, 2009, 27(3): 174-176.

ZHANG Zhe, GUO Miao-li, GUO Jun-sheng. Influnce of germanium on PGE of rat with rheumatoid arthritis[J]. Journal of Pharmaceutical Practice and Service, 2009, 27(3): 174-176.

Citation:

ZHANG Zhe, GUO Miao-li, GUO Jun-sheng. Influnce of germanium on PGE of rat with rheumatoid arthritis[J]. Journal of Pharmaceutical Practice and Service, 2009, 27(3): 174-176.

锗对关节炎大鼠PGE₂的影响

第二军医大学海军医学系,上海200433

基金项目: 中国营养学会科研基金(yj0606)

Influnce of germanium on PGE of rat with rheumatoid arthritis

School of pharmacy, Second Military Medical University, Shanghai 200433, China

摘要: 目的:探讨锗(Germanium,Ge)对关节炎大鼠前列腺素E₂(Prostaglandin E₂,PGE₂)的调节作用。方法:利用弗氏完全佐剂(Freund's complete adjuvant,FCA)诱导制造关节炎大鼠模型,用不同剂量的β-羧乙基锗倍半氧化物(carboxyethylgermanium sesquioxide,Ge-132)进行治疗。于造模前、造模后第3、6、9、12、15、18、21d观测每只大鼠的一般情况,计算体重增长率和足跖肿胀率。造模后21 d断头处死大鼠,测量组织内炎症介质PGE₂的含量。结果:经过干预后,锗中、高剂量组及阳性药物组大鼠的食欲、活力、体重和足跖肿胀等状况优于模型组。组织内炎症介质PGE₂的含量,锗中、高剂量组及阳性药物组均显著低于模型组(P<0.01),干预组中锗高剂量组最低,其次为锗中剂量和阳性药物组,锗低剂量组为最高。结论:各剂量的锗均可显著下调关节炎大鼠炎症介质PGE₂,高剂量的锗效果优于吲哚美辛(indomethacin,IDMT),锗对关节炎大鼠的PGE₂调节作用有剂量效应关系。
- 锗 /
- 关节炎 /
- 前列腺素E₂
Abstract: Objective :To investigate the regulatory effect of germanium(Ge) on PGE₂ of the rheumatoid arthritic model. Methods :The rat model of rheumatoid arthritis(RA) induced by Freund's complete adjuvant(FCA) was interfered with different dosages of β-carboxyethylgermanium sesquioxide(Ge-132).The body weight and the paw volume of each rat model were measured at the 3rd,6th,12th,15th,18th and 21st days,and the weight growth rate and paw swelling rate were caculated.After rats was quickly beheaded at the 21st day,the contents of Prostaglandin E₂(PGE₂) in the tissue were measured. Results :Appetite,energy,weight gains and the paw volume of germanium with middle and high dosages and Indomethacin(IDMT) treated groups were better then those of the model group(P<0.01).Compared with the IDMT treated group,the level of tissue inflammatory mediator PGE₂ in germanuium with middle and high dosages and the normal saline treated groups were significantly lower than that of the model group(P<0.01),and the germanuium with high dosage was the lowest one,while the germanuium with middle dosage and the IDMT treated groups were in the second place,and the germanuium with low dosage was the highest one among all the groups. Conclusion :All the dosages of germanuium were able to decrease PGE₂ significantly by measuring the content of the inflammatory mediator;the high dosed germanuium gave better anti-inflammatory effects on the experimental RA rat model than IDMT.There was a relationship between the dose and enhancement effect of germanuium.
- germanium /
- rheumatoid arthritis /
- prostaglandin E₂

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锗对关节炎大鼠PGE₂的影响

第二军医大学海军医学系,上海200433

基金项目: 中国营养学会科研基金(yj0606)

收稿日期: 2009-03-10

关键词:

锗 /

关节炎 /

前列腺素E₂

摘要: 目的:探讨锗(Germanium,Ge)对关节炎大鼠前列腺素E₂(Prostaglandin E₂,PGE₂)的调节作用。方法:利用弗氏完全佐剂(Freund's complete adjuvant,FCA)诱导制造关节炎大鼠模型,用不同剂量的β-羧乙基锗倍半氧化物(carboxyethylgermanium sesquioxide,Ge-132)进行治疗。于造模前、造模后第3、6、9、12、15、18、21d观测每只大鼠的一般情况,计算体重增长率和足跖肿胀率。造模后21 d断头处死大鼠,测量组织内炎症介质PGE₂的含量。结果:经过干预后,锗中、高剂量组及阳性药物组大鼠的食欲、活力、体重和足跖肿胀等状况优于模型组。组织内炎症介质PGE₂的含量,锗中、高剂量组及阳性药物组均显著低于模型组(P<0.01),干预组中锗高剂量组最低,其次为锗中剂量和阳性药物组,锗低剂量组为最高。结论:各剂量的锗均可显著下调关节炎大鼠炎症介质PGE₂,高剂量的锗效果优于吲哚美辛(indomethacin,IDMT),锗对关节炎大鼠的PGE₂调节作用有剂量效应关系。

English Abstract

Influnce of germanium on PGE of rat with rheumatoid arthritis

School of pharmacy, Second Military Medical University, Shanghai 200433, China

Received Date: 2009-03-10

Keywords:

Abstract: Objective :To investigate the regulatory effect of germanium(Ge) on PGE₂ of the rheumatoid arthritic model. Methods :The rat model of rheumatoid arthritis(RA) induced by Freund's complete adjuvant(FCA) was interfered with different dosages of β-carboxyethylgermanium sesquioxide(Ge-132).The body weight and the paw volume of each rat model were measured at the 3rd,6th,12th,15th,18th and 21st days,and the weight growth rate and paw swelling rate were caculated.After rats was quickly beheaded at the 21st day,the contents of Prostaglandin E₂(PGE₂) in the tissue were measured. Results :Appetite,energy,weight gains and the paw volume of germanium with middle and high dosages and Indomethacin(IDMT) treated groups were better then those of the model group(P<0.01).Compared with the IDMT treated group,the level of tissue inflammatory mediator PGE₂ in germanuium with middle and high dosages and the normal saline treated groups were significantly lower than that of the model group(P<0.01),and the germanuium with high dosage was the lowest one,while the germanuium with middle dosage and the IDMT treated groups were in the second place,and the germanuium with low dosage was the highest one among all the groups. Conclusion :All the dosages of germanuium were able to decrease PGE₂ significantly by measuring the content of the inflammatory mediator;the high dosed germanuium gave better anti-inflammatory effects on the experimental RA rat model than IDMT.There was a relationship between the dose and enhancement effect of germanuium.

张哲, 郭苗莉, 郭俊生. 锗对关节炎大鼠PGE2的影响[J]. 药学实践与服务, 2009, 27(3): 174-176.

引用本文:

张哲, 郭苗莉, 郭俊生. 锗对关节炎大鼠PGE₂的影响[J]. 药学实践与服务, 2009, 27(3): 174-176.

ZHANG Zhe, GUO Miao-li, GUO Jun-sheng. Influnce of germanium on PGE of rat with rheumatoid arthritis[J]. Journal of Pharmaceutical Practice and Service, 2009, 27(3): 174-176.

Citation:

ZHANG Zhe, GUO Miao-li, GUO Jun-sheng. Influnce of germanium on PGE of rat with rheumatoid arthritis[J]. Journal of Pharmaceutical Practice and Service, 2009, 27(3): 174-176.