摘要:
目的 考察室温下8h内诺氟沙星与7种常用注射液(5%葡萄糖注射液,10%葡萄糖注射液,5%葡萄糖氯化钠注射液,10%葡萄糖氯化钠注射液,复方氯化钠注射液,0.9%氯化钠注射液,乳酸钠注射液)的配伍稳定性.方法 采用褶合光谱法,并结合外观和pH值检查法,以差谱值予以定量表达.结果 诺氟沙星与上述常用注射液配伍后在8h内,外观均无变化,pH值变化不显著,除诺氟沙星与乳酸钠注射液配伍在4、6、8h的褶合光谱的差谱值分别为11.51%,19.73%,24.81%外,其余各差谱值均小于10%.结论 室温下8h 内,除诺氟沙星与乳酸钠注射液不能配伍外,与其余6种常用输液均能配伍使用,褶合光谱法为药物稳定性研究提供了一个新的手段.
Abstract:
Objective To observe the chemical stabihty of seven common injections (5% glucose injection, 10% glucose injection, 5% glucose and sodium chloride injection, 10% glucose and sodium chloride injection, compound sodium chloride injection, 0.9% sodium chloride injection, sodium lactate injection) mixed with norfloxacin at room temperature for 8 hours. Methods A convolution spectrometry was used, the appearance was observed and pH value was tested. The results were described quantitatively by subtract spectrometry value. Results There were no obvious changes in the appearances and pH in 8 hours. Except that the subtract spectrometry values of norfloxacin with sodium lactate injection in 4, 6, 8h were 11.51%,19.73%,24.81%, the others were less than 10%. Conclusion Norfloxacin can be mixed with other common injections except sodium lactate injection at room temperature for 8 hours. The convolution spectrometry provides a new method for the research of the stability of drugs.
点击查看大图
下载:
