甲硝唑乳膏的制备及质量控制
Preparation and quality control of metronidazole cream
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摘要: 目的 制备甲硝唑乳膏并建立其质量控制标准。方法 以甲硝唑为主药制备甲硝唑乳膏,采用紫外分光光度法测定甲硝唑乳膏中甲硝唑的含量。结果 甲硝唑的平均回收率为100.2%,RSD为1.7%。结论 该制剂处方及工艺具有生产可行性,其质量控制标准符合《中国药典》要求,含量测定方法简单、快速、准确。Abstract: Objective To prepare metronidazole cream and establish quality control standard. Methods The cream was prepared by taking metronidazole as main components. The contents of metronidazole was determined by UV spectrometry. Results The average recovery of metronidazole was 100.2%, RSD was 1.7%. Conclusion The cream can be prepare feasibly. The method of quality control is simple,rapid and accurate.
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Key words:
- metronidazole /
- cream /
- quality control
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