2024 Vol. 42, No. 9
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2024, 42(9): 365-374.
doi: 10.12206/j.issn.2097-2024.202405026
Abstract:
Remazolam is a new ultra-short-acting benzodiazepine that produces sedation by acting on γ-aminobutyric acid type A（GABAA）receptors. Remazolam has characteristics of rapid onset of action, short half-life, high clearance, and no accumulation in the b...
Remazolam is a new ultra-short-acting benzodiazepine that produces sedation by acting on γ-aminobutyric acid type A（GABAA）receptors. Remazolam has characteristics of rapid onset of action, short half-life, high clearance, and no accumulation in the b...
2024, 42(9): 375-378.
doi: 10.12206/j.issn.2097-2024.202312075
Abstract:
Ferroptosis, discovered in 2012, is a newly form of non-apoptotic and non-necrotic cell death, which is characterized by an increasement in lipid peroxidation and accumulation of intracellular iron ions. Glutathione peroxidase 4（GPX4）is the fourth me...
Ferroptosis, discovered in 2012, is a newly form of non-apoptotic and non-necrotic cell death, which is characterized by an increasement in lipid peroxidation and accumulation of intracellular iron ions. Glutathione peroxidase 4（GPX4）is the fourth me...
2024, 42(9): 379-384, 410.
doi: 10.12206/j.issn.2097-2024.202404062
Abstract:
Objective To improve the cellular uptake efficiency and the therapeutic effect through the structural modification of paclitaxel （PTX） and the preparation of corresponding liposomes. Methods The prodrug of paclitaxel, PTX-PA, was prepared by e...
2024, 42(9): 385-388, 398.
doi: 10.12206/j.issn.2097-2024.202308045
Abstract:
Objective Hand-foot syndrome is a dose-limiting toxicity of capecitabine. At present, there is no unified gold standard for the establishment of hand-foot syndrome model. To induce hand-foot syndrome and provide a reference for the establishment of...
2024, 42(9): 389-398.
doi: 10.12206/j.issn.2097-2024.202404096
Abstract:
Objective To investigate the therapeutic effect of Qiwei Zhigan prescription on two classic animal models of non-alcoholic steatohepatitis（NASH）. Methods Methionine-choline-deficient（MCD）rat model and choline-deficient, L-amino acid-defined, h...
2024, 42(9): 399-401, 406.
doi: 10.12206/j.issn.2097-2024.202404063
Abstract:
Objective To establish a high-precision and high-specificity quantitative nuclear magnetic resonance phosphorus spectrometry method（31P-qNMR）for detecting the phosphorus content in calcium hydrogen phosphate chewable tablets. Methods Hexamethy...
2024, 42(9): 402-406.
doi: 10.12206/j.issn.2097-2024.202403030
Abstract:
Objective To develop a high performance liquid chromatography-tandem mass spectrometry （HPLC-MS/MS） method for simultaneous determination of five flavonoids in Ganmao’an granules （GMA）. Methods Chromatographic separation was achieved on a Kro...
2024, 42(9): 407-410.
doi: 10.12206/j.issn.2097-2024.202407037
Abstract:
Objective To investigate the efficacy of oral Danning tablets for bowel preparation for colonoscopy in diabetes mellitus patients. Methods A study was conducted from November 2022 to May 2024, 100 type 2 diabetic patients （aged≥30 years）admitt...
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