2024 Vol. 42, No. 8
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2024, 42(8): 319-324.
doi: 10.12206/j.issn.2097-2024.202308062
Abstract:
Chiral drugs are closely related to the safety and effectiveness of drug use. Most dihydropyridine drugs have chiral carbon atoms, which are used as racemes and produce stereoselective disposal characteristics after entering the body, and may affect ...
Chiral drugs are closely related to the safety and effectiveness of drug use. Most dihydropyridine drugs have chiral carbon atoms, which are used as racemes and produce stereoselective disposal characteristics after entering the body, and may affect ...
2024, 42(8): 325-333.
doi: 10.12206/j.issn.2097-2024.202401033
Abstract:
Objective To study the mechanism of antidepressant effect of Baihe Zhimu decoction based on NLRP1 inflammasome. Methods A chronic unpredictable mild stress（CUMS）induced depression mouse model was constructed. C57BL/6J mice were randomly divide...
2024, 42(8): 334-340.
doi: 10.12206/j.issn.2097-2024.202303023
Abstract:
Objective To make the cost-effectiveness analysis of pembrolizumab and platinum chemotherapy as the first-line treatment for advanced non-small cell lung cancer （NSCLC） in the population with tumor proportion score （TPS） ≥ 1% of PD-L1, and provide ...
2024, 42(8): 341-345.
doi: 10.12206/j.issn.2097-2024.202404082
Abstract:
Objective To establish an UPLC-MS/MS method for determinating content of three paclitaxel fatty acid esters such as paclitaxel myristate （PTX-MA）, paclitaxel palmitate （PTX-PA） and paclitaxel myristate （PTX-SA） in mouse plasma, and preliminarily in...
2024, 42(8): 346-349.
doi: 10.12206/j.issn.2097-2024.202211047
Abstract:
Objective To study the sedative and hypnotic effects of Yening Capsules and investigate its bioactive mechanism in mice. Methods The mice were randomly divided into control group, estazolam group （0.8 mg/kg）, low, medium and high-dose Yening C...
2024, 42(8): 350-358.
doi: 10.12206/j.issn.2097-2024.202303048
Abstract:
Objective To predict the potential Q-markers of Abri Herba based on network pharmacology and molecular docking and establish a quality control characteristic. Methods The network relationship of “Abri Herba - component - target - pathway” was ...
2024, 42(8): 359-364.
doi: 10.12206/j.issn.2097-2024.202310015
Abstract:
Objective To explore the ideas and measures to further optimize China’s drug emergency approval system by comparing the drug emergency approval systems in China and other countries. Methods The current situation of China’s drug emergency appro...
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