药学实践与服务

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2024 Vol. 42, No. 11

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Reviews

Progress on the treatment of sepsis

SONG Zecheng, CHEN Linlin, LU Renyi, LIU Mengxiao, WANG Yan

2024, 42(11): 457-460, 502. doi: 10.12206/j.issn.2097-2024.202405059

Abstract(7437) HTML (2550) PDF (1208KB)(149)

Abstract:
Sepsis is a severe and life-threatening symptom that poses a significant risk to human health. Treatment mainly involves supportive care, but research on new drugs is ongoing. Advancements have been achieved in the management of immune function, infl...

Original articles

Identification and expression pattern analysis of FBXL gene family in Salvia miltiorrhiza

YAO Ruiyang, YU Haizheng, LI Yaoxin, ZHANG Lei

2024, 42(11): 461-470. doi: 10.12206/j.issn.2097-2024.202407034

Abstract(2167) HTML (784) PDF (3972KB)(17)

Abstract:
Objective To identify and analyze the bioinformatics and expression patterns of the F-box-LRR（FBXL） gene family of Salvia miltiorrhiza based on genomic data, and provide a foundation for further elucidating its gene functions. Methods The SmF...

Study on the potential mechanism of JQQSG for the treatment of CAP based on network pharmacology and molecular docking technology

CHEN Jintao, QIAO Ziying, MA Minghua, ZHANG Ruoxi, WANG Zhenwei, NIAN Hua

2024, 42(11): 471-478. doi: 10.12206/j.issn.2097-2024.202312014

Abstract(6534) HTML (2812) PDF (2177KB)(77)

Abstract:
Objective To investigate the possible mechanism of action of Jinqi Qingshu granules （JQQSG） in the treatment of community-acquired pneumonia （CAP） by network pharmacology and molecular docking technology. Methods The TCMSP database and SwissTa...

Mechanism of effective ingredients of Dingqing tablets in the treatment of leukemia based on network pharmacology and molecular docking technology

CHEN Jing, HE Ruihua, WENG Yue, XU Yi, LIU Jing, HUANG Jin

2024, 42(11): 479-486. doi: 10.12206/j.issn.2097-2024.202401073

Abstract(4088) HTML (1309) PDF (3370KB)(65)

Abstract:
Objective To explore the material basis and mechanism of the Chinese medicine Dingqing tablets in the treatment of leukemia. Methods The potential active ingredients of Dingqing tablets were retrieved through TCMSP and HERB Database and the ta...

Effects of MT-1207 on blood glucose, blood lipids and atherosclerosis in mice

ZHANG Xiuping, TIAN Jiasheng, WANG Daoxin, LI Jiaxin, WANG Pin, MIAO Chaoyu

2024, 42(11): 487-494. doi: 10.12206/j.issn.2097-2024.202306011

Abstract(5462) HTML (2019) PDF (1685KB)(10)

Abstract:
Objective To study the effect of MT-1207 on blood glucose, blood lipids and atherosclerosis in mice. Methods The apolipoprotein E knockout (ApoE-/-) mice were fed with^normal feed, drug feed containing losartan and drug feed containing MT-1207...

Optimization of the preparation process for lenvatinib mixed micelles by central composite design-response surface methodology

KAILIBINUER Aobuliaisan, LI Qian, XIE Zhi, JIA Wenyan, YIN Dongfeng

2024, 42(11): 495-502. doi: 10.12206/j.issn.2097-2024.202403019

Abstract(2477) HTML (1721) PDF (1395KB)(9)

Abstract:
Objective To optimize the formulation and preparation process of lenvatinib mixed micelles. Methods Hybrid micelles of lenvatinib were prepared by film hydration method, with Pluronic P123 and F127 as carrier materials. Optimal formulation was...