2023 Vol. 41, No. 1
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2023, 41(1): 1-7, 35.
doi: 10.12206/j.issn.2097-2024.202203113
Abstract:
Immunoparalysis is the main cause of death in patients with intermediate and terminal sepsis. The correction of immunoparalysis is an important direction of sepsis treatment. In the pathological process of sepsis, a variety of factors contribute to ...
Immunoparalysis is the main cause of death in patients with intermediate and terminal sepsis. The correction of immunoparalysis is an important direction of sepsis treatment. In the pathological process of sepsis, a variety of factors contribute to ...
2023, 41(1): 8-13.
doi: 10.12206/j.issn.2097-2024.202101032
Abstract:
Osteoporosis is a systemic bone metabolism disease characterized by low bone mass, bone microstructure destruction, increased bone fragility, and easy fracture, which is more common in the elderly. Animal medicine, as an important part of natural med...
Osteoporosis is a systemic bone metabolism disease characterized by low bone mass, bone microstructure destruction, increased bone fragility, and easy fracture, which is more common in the elderly. Animal medicine, as an important part of natural med...
2023, 41(1): 14-17.
doi: 10.12206/j.issn.2097-2024.202105086
Abstract:
Reactive oxygen species（ROS） responsive liposomes are prepared based on the high level of ROS expression in the tumor microenvironment, enabling precise drug delivery to the tumor site. With the addition of photosensitizer, the controllability of dr...
Reactive oxygen species（ROS） responsive liposomes are prepared based on the high level of ROS expression in the tumor microenvironment, enabling precise drug delivery to the tumor site. With the addition of photosensitizer, the controllability of dr...
2023, 41(1): 18-25.
doi: 10.12206/j.issn.2097-2024.202206050
Abstract:
Objective To design and synthesize autophagic degraders targeting BRD4 based on autophagosome tethering compound (ATTEC) strategy and test their BRD4 degradation activity. Methods BRD4-targeting ATTECs were constructed by conjugating ispine...
2023, 41(1): 26-30, 55.
doi: 10.12206/j.issn.2097-2024.202207001
Abstract:
Objective To prepare a biomimetic nano carrier macrophage membrane hybrid liposome by heterozygous macrophage membrane and liposome, which could be used for the clearance and toxicity inhibition of Vibrio vulnificus hemolysin A (VvhA). Methods ...
2023, 41(1): 31-35.
doi: 10.12206/j.issn.2097-2024.202203034
Abstract:
Objective To investigate the rules of Traditional Chinese Medicine in the treatment of perimenopausal syndrome (PMS) and provide a theoretical basis for the clinical treatment of PMS. Methods The literature related to PMS were collected from C...
2023, 41(1): 36-39, 62.
doi: 10.12206/j.issn.2097-2024.202108066
Abstract:
Objective To establish a near infrared (NIR) quantitative model for the dissolution behavior of aripiprazole tablets. Methods The NIR spectra of aripiprazole tablets were collected and the dissolution tests were performed to determine the diss...
2023, 41(1): 40-44, 49.
doi: 10.12206/j.issn.2097-2024.202111111
Abstract:
Objective To explore the therapeutic effects of estrogen-intervened endothelial progenitor cells( EPCs) transplantation on diabetic ischemic stroke rats. Methods PKH26-labeled diabetic EPCs and estrogen-intervened diabetic EPCs were injected ...
2023, 41(1): 45-49.
doi: 10.12206/j.issn.2097-2024.202108090
Abstract:
Objective To optimize the formulation and preparation of diphenhydramine hydrochloride and caffeine orally disintegrating tablet. Methods Melt granulation technology of steric acid and API was used to mask the unpleasant tasting of diphenhyd...
2023, 41(1): 50-55.
doi: 10.12206/j.issn.2097-2024.202206035
Abstract:
Objective To study the genotoxicities of raceanisodamine hydrochloride injection. Methods B acterial reverse mutation test, in vitro Chromosomal aberration test and in vivo Micronucleus test were performed to investigate the genotoxicities of race...
2023, 41(1): 56-58.
doi: 10.12206/j.issn.2097-2024.202208052
Abstract:
Objective To observe the short-term clinical effect of compound phellodendron gargle combined with the total glucosides of paeony (TGP) in the treatment of erosive oral lichen planus (OLP). Methods 6 2 patients were divided into observation group ...
2023, 41(1): 59-62.
doi: 10.12206/j.issn.2097-2024.202102009
Abstract:
Objective To investigate the role of clinical pharmacists in individualized treatment and pharmaceutical care for a Crohn’s disease patient with non-response to infliximab. Methods The clinical pharmacist participated in the pharmaceutical car...
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