2022 Vol. 40, No. 6
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2022, 40(6): 485-493.
doi: 10.12206/j.issn.2097-2024.202204037
Abstract:
α7 nicotinic acetylcholine receptor (α7nAChR) belongs to nicotinic acetylcholine receptors (nAChRs), which is the key receptor in cholinergic anti-inflammatory pathway and plays an important role in the neural regulation of immune system. Recent stud...
α7 nicotinic acetylcholine receptor (α7nAChR) belongs to nicotinic acetylcholine receptors (nAChRs), which is the key receptor in cholinergic anti-inflammatory pathway and plays an important role in the neural regulation of immune system. Recent stud...
2022, 40(6): 494-498, 504.
doi: 10.12206/j.issn.2097-2024.202201016
Abstract:
Objective To explore the polymorphism of microbial community after laparoscopic abdominal exploration by using bacterial 16s ribosomal DNA (16S rDNA) sequencing technology. Methods New Zealand rabbits were divided into model group and control ...
2022, 40(6): 499-504.
doi: 10.12206/j.issn.2097-2024.202206081
Abstract:
Objective In order to obtain small molecule compounds with novel structure and good biological activity, the secondary metabolites of polar sponge-symbiotic Streptomyces sp. LHW11-07 were studied. Methods The fermentation product of Streptomyc...
2022, 40(6): 505-509.
doi: 10.12206/j.issn.2097-2024.202111068
Abstract:
Objective To investigate the anti-inflammatory effect and mechanism of wilforine. Methods Anti-inflammatory activity of wilforine was investigated in LPS-induced RAW264.7 cells. The cytokines production of RAW264.7 cells was analyzed by ELISA ...
2022, 40(6): 510-514.
doi: 10.12206/j.issn.2097-2024.202206057
Abstract:
Objective To study the hypoglycemic effect of Polygonatum sibiricum polysaccharides on type 2 diabetic mice and its effects on intestinal flora and pathological structure of small intestine. Methods Fifty male mice were used, except 10 were fe...
2022, 40(6): 515-518, 531.
doi: 10.12206/j.issn.2097-2024.202112012
Abstract:
Objective To study the intestinal absorption characteristics of apixaban in rats with renal failure, and the effect of P-glycoprotein (P-gp) inhibitors on its absorption behavior. Methods The in vivo absorption experiment was performed in CRF ...
2022, 40(6): 519-525, 545.
doi: 10.12206/j.issn.2097-2024.202104112
Abstract:
Objective To explore the molecular targets and associated potential pathways of Kunxian capsule in the treatment of rheumatoid arthritis (RA) based on network pharmacology. Methods The constituents of Kunxian capsule were searched by Traditiona...
2022, 40(6): 526-531.
doi: 10.12206/j.issn.2097-2024.202106117
Abstract:
Objective To evaluate the quality of coenzyme Q10 emulsion with improved formulation and technology and establish an assay method. Methods Coenzyme Q10 emulsion with a high oil concentration was prepared and analyzed by HPLC. The physical an...
2022, 40(6): 532-535.
doi: 10.12206/j.issn.2097-2024.202105136
Abstract:
Objective To investigate the effect of different freezing thawing conditions on the stability of metronidazole sodium chloride injection in extreme cold environment. Methods The freezing process of metronidazole sodium chloride injection in ex...
2022, 40(6): 536-539.
doi: 10.12206/j.issn.2097-2024.202202083
Abstract:
Objective To study the acute toxicity of tetrodotoxin to zebra fish. Methods The maximum non-lethal concentration (MNLC) and 10% lethal concentration (LC10) determinations were used to assess the acute toxicity of tetrodotoxin. Results Ac...
2022, 40(6): 540-545.
doi: 10.12206/j.issn.2097-2024.202206045
Abstract:
Objective To compare the difference of volatile organic compounds (VOCs) in the urine of diabetic patients comorbid with or without depression. Methods Patients with type 2 diabetes who met the diagnostic criteria of prevention and treatment ...
2022, 40(6): 546-549.
doi: 10.12206/j.issn.2097-2024.202207061
Abstract:
Objective To establish the quality standard of Gansu granules (GGs) and effectively control the quality of GGs. Methods TLC identification method of Gansu granules was improved by using pinocembrin-7-O-β-D-glucoside as the indicator. In HPLC a...
2022, 40(6): 550-552, 562.
doi: 10.12206/j.issn.2097-2024.202109100
Abstract:
Objective To assay the contents of acetaminophen with ultra high-performance liquid chromatography (UHPLC) method in the sustained-release tablets radiated by Gamma ray. Methods Acetaminophen sustained-release tablets were radiated by 60Co. U...
2022, 40(6): 553-556, 570.
doi: 10.12206/j.issn.2097-2024.202202038
Abstract:
Objective To establish the method for the simultaneous determination of liquiritin, ammonium glycyrrhizinate, hesperidin, nobiletin;tangeretin;costunolide, dehydrocostuslactone in Chenxiang Lubailu tablet by HPLC. Methods ZORBAX Eclipse XDB-C...
2022, 40(6): 557-562.
doi: 10.12206/j.issn.2097-2024.202201042
Abstract:
Objective To establish a quality control system of volatile oil of Chunyang Zhengqi capsules. Methods The chromatogram of volatile oil was established by GC method, and the contents of cinnamaldehyde and eugenol were determined. Results ...
2022, 40(6): 563-570.
doi: 10.12206/j.issn.2097-2024.202204049
Abstract:
Objective To explore the anti-inflammatory and hepatoprotective mechanism of Shuganning injection through establishing the active ingredients-targets network and protein interactions network. Methods The main active ingredients of Artemisiae s...
2022, 40(6): 571-575.
doi: 10.12206/j.issn.2097-2024.202203068
Abstract:
Objective To investigate the influence of renal failure on the area under curve (AUC) and adverse reactions of docetaxel in breast cancer patients, and provide evidence for the dosage of docetaxel in renal failure patients. Methods A retrospec...
2022, 40(6): 576-579.
doi: 10.12206/j.issn.2097-2024.202206091
Abstract:
Objective To evaluate the effect of Ulinastatin injection on inflammation, hemodynamics, oxygenation index (PaO2/FiO2) and prognosis in patients with septic shock. Methods A retrospective analysis was performed on clinical data of 109 patients...
2022, 40(6): 580-582.
doi: 10.12206/j.issn.2097-2024.202107101
Abstract:
Objective To explore the effective management of post-operation infections through clinical pharmacists participating in the treatment of a gastric cancer patient with post operation abdominal infection and cellulitis. Methods Clinical pharma...
2022, 40(6): 583-586.
doi: 10.12206/j.issn.2097-2024.202009044
Abstract:
Objective To retrospectively analyze the use of antiviral drugs in 1765 patients admitted to a hospital of COVID-19 in Hubei Province, and to provide experience and suggestions for clinical rational drug use. Methods The antiviral drugs used i...
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