2021 Vol. 39, No. 2
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2021, 39(2): 97-101.
doi: 10.12206/j.issn.1006-0111.202006087
Abstract:
Paeoniae Radix Rubra has the effects of clearing heat, cooling blood, dissipating blood stasis and pain relieving (in terms of Chinese medicine). Paeoniae Radix Rubra and its active ingredients have significant pharmacological effects in anti-tumor, ...
Paeoniae Radix Rubra has the effects of clearing heat, cooling blood, dissipating blood stasis and pain relieving (in terms of Chinese medicine). Paeoniae Radix Rubra and its active ingredients have significant pharmacological effects in anti-tumor, ...
2021, 39(2): 102-107.
doi: 10.12206/j.issn.1006-0111.202012003
Abstract:
Hepatitis C virus (HCV) is an important factor leading to chronic hepatitis, cirrhosis and hepatocellular carcinoma. Currently, there is no vaccine available to prevent HCV infection. This article reviews the natural products with anti-HCV activity d...
Hepatitis C virus (HCV) is an important factor leading to chronic hepatitis, cirrhosis and hepatocellular carcinoma. Currently, there is no vaccine available to prevent HCV infection. This article reviews the natural products with anti-HCV activity d...
2021, 39(2): 108-111.
doi: 10.12206/j.issn.1006-0111.202010022
Abstract:
Objective To investigate the effect of different guanine base numbers on the fluorescence intensity of DNA/ silver nanoclusters through C-G base complementary pairing, in order to explore a new method for the construction of fluorescent probe switc...
2021, 39(2): 112-117.
doi: 10.12206/j.issn.1006-0111.202012006
Abstract:
Objective To investigate the effects of upadacitinib on the polarization and inflammation of BV2 microglia after oxygen glucose deprivation/recovery (OGD/R) and to explore its mechanism of action. Methods The experiment was divided into 3 group...
2021, 39(2): 118-120, 125.
doi: 10.12206/j.issn.1006-0111.202012019
Abstract:
Objective To evaluate the transdermal safety of lanthanum (La) in sunscreen and jellyfish sting protective lotion, establish a microwave digestion-inductively coupled plasma opticalemission spectroscopy (ICP-OES) method for determination of lanthan...
2021, 39(2): 121-125.
doi: 10.12206/j.issn.1006-0111.202012002
Abstract:
Objective To study the effects of atherosclerotic high-fat diet on body weight, blood glucose, blood lipid levels and atherosclerotic plaque formation in mice, and to determine the effect of fasting time on the results of blood lipid testing. Met...
2021, 39(2): 126-129.
doi: 10.12206/j.issn.1006-0111.202009031
Abstract:
Objective To find novel lead compounds as p53-MDM2 inhibitors by drug repurposing strategy. Methods The p53-MDM2 inhibitory activities of compounds were determined by FP and western blotting. MTT method was used to determine the in-vitro antitu...
2021, 39(2): 130-133.
doi: 10.12206/j.issn.1006-0111.202101006
Abstract:
Objective To establish the chemical synthesis of the active ingredient rosavin of Rhodiola rosea. Methods β-D-pentaacetylglucose, 1-hydroxy-2,3,4-triacetylarabinose and cinnamyl alcohol were used as starting materials. The target compound was p...
2021, 39(2): 134-137, 142.
doi: 10.12206/j.issn.1006-0111.202102006
Abstract:
Objective To study the effect of nicotinamide mononucleotide (NMN) on the mortality of the lipopoly-saccharide (LPS)-induced endotoxic shock mouse model. Methods 10-week-old C57BL/6J male mice were randomly divided into groups, and were injecte...
2021, 39(2): 138-142.
doi: 10.12206/j.issn.1006-0111.202012004
Abstract:
Objective To investigate the role of vestibular organs on stress analgesia induced by rotation in mice. Methods Female mice were randomly divided into morphine group and rotation group. After 15 minutes of intraperitoneal injection of naloxone ...
2021, 39(2): 143-147.
doi: 10.12206/j.issn.1006-0111.202101003
Abstract:
Objective To find the effect of leonurine on LPS-induced macrophages activation and its potential mechanism. Methods Mouse primary peritoneal macrophages were isolated and pretreated for 24 h with LPS and leonurine. MTT assay was used to detect...
2021, 39(2): 148-151, 156.
doi: 10.12206/j.issn.1006-0111.202012017
Abstract:
Objective To establish a method to determine 11 main components in Hanshi yufei decoction. Methods The method adopted UHPLC-MS/MS with an Agilent ZORBAX SB-C18 (3.5 μm, 2.1 mm×150 mm) column. The mobile phase was consisted of 0.2% formic acid p...
2021, 39(2): 152-156.
doi: 10.12206/j.issn.1006-0111.202006053
Abstract:
Objective To establish a RP-HPLC method for determination of ketoconazole, mupirocin and mometasone furoate in compound ketoconazole ointment. Methods RP-HPLC was conducted on a Intersil ODS-3 column (250 mm×4.6 mm, 5 μm), with methanol-PBS wit...
2021, 39(2): 157-159.
doi: 10.12206/j.issn.1006-0111.202007059
Abstract:
Objective To establish a LC-MS/MS method for the determination of salidroside in the capsule. Methods An electrospray ionization and multiple reaction detection were used to detect negative ion. Theophylline was used as standard. The detection ...
2021, 39(2): 160-163.
doi: 10.12206/j.issn.1006-0111.202008017
Abstract:
Objective To establish an UPLC-MS/MS method of voriconazole assay in human plasma for clinical therapeutic drug monitoring. Methods The plasma samples were treated with methanol to precipitate protein and the supernatants were assayed by UPLC-M...
2021, 39(2): 164-168, 177.
doi: 10.12206/j.issn.1006-0111.202009010
Abstract:
Objective To evaluate clinical utility of the personalized drug delivery decision support system, Smart Dose, applied to the monitoring of therapeutic drugs in Chinese population. Methods Use Smart Dose system to predict the trough concentratio...
2021, 39(2): 169-173.
doi: 10.3969/j.issn.1006-0111.202008042
Abstract:
Objective To provide reference for anti-infection treatment and individual pharmaceutical care in patient on peritoneal dialysis. Methods The plasma concentration of vancomycin in patient on peritoneal dialysis was monitored by clinical pharmac...
2021, 39(2): 174-177.
doi: 10.12206/j.issn.1006-0111.202012022
Abstract:
Objective To explore the strategies of drug treatment and pharmaceutical care for children with bacterial meningitis. Methods The anti-infective therapy, therapeutic drug monitoring and dose adjustment of vancomycin in children with bacterial m...
2021, 39(2): 178-181, 190.
doi: 10.12206/j.issn.1006-0111.202012020
Abstract:
Objective To explore the formulation and adjustment of nutritional therapy by nutrition support pharmacists in patient with acute prerenal failure complicated with urinary tract infection, and to provide a reference for nutritional therapy in such ...
2021, 39(2): 182-185.
doi: 10.12206/j.issn.1006-0111.202008016
Abstract:
Objective To explore the clinical pharmacist participation in the treatment of pregnancy complicated with Clostridium difficile infection. Methods From the perspective of medications, clinical pharmacists followed evidence-based medical practic...
2021, 39(2): 186-190.
doi: 10.12206/j.issn.1006-0111.202005092
Abstract:
Objective To analyze the quality of the hospital preparation magnesium sulfate oral solution by using capability sixpack. Methods By using the capability sixpack of Minitab, the content of magnesium sulfate in the magnesium sulfate oral solutio...
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