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2019 Vol. 37, No. 4

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Research progress on the pathogenesis of isoniazid induced liver injury
WANG Yupeng, BAO Jie
2019, 37(4): 289-293. doi: 10.3969/j.issn.1006-0111.2019.04.001
Abstract(6453) PDF (979KB)(822)
Abstract:
Isoniazid(INH) is one of the most important drugs for the prevention and treatment of tuberculosis,and is the first choice for the four major first-line anti-tuberculosis drugs.A series of studies have shown that isoniazid has hepatotoxicity,and the ...
Protective effect of areca catechu linn ethanol extract against hypoxia in H9C2 cells
ZHAO Anpeng, JIN Ting, WANG Rong
2019, 37(4): 294-298. doi: 10.3969/j.issn.1006-0111.2019.04.002
Abstract:
Objective To study the protective effect and mechanism of anhydrous ethanol extract of areca catechu linn against hypoxia in H9C2 cells. Methods Myocardial cell hypoxic mold was established by H9C2 cell line.The effect of areca catechu linn anhydro...
Protective effects of Gallic acid on ionizing irradiated HIEC cells
SUN Huijuan, ZHAO Tao
2019, 37(4): 299-303. doi: 10.3969/j.issn.1006-0111.2019.04.003
Abstract:
Objective To investigate the protective effect and primary mechanism of Gallic acid on 60Co-γ ray induced Human Intestinal Epithelial cell (HIEC) damage. Methods HIEC in the exponential phase were inoculated in petri dishes and were randomly divide...
Protective effect of Shengxian decoction and each single herb component against adriamycin-induced cardiomyocyte injury
MAN Huan, ZHANG Feng, HUANG Doudou, XIONG Xiaojuan, ZHAN Qin, LIAO Lina, LI Tiejun, CHEN Wansheng
2019, 37(4): 304-308. doi: 10.3969/j.issn.1006-0111.2019.04.004
Abstract:
Objective To study the protective effect of Shengxian decoction (SXT) and its each single herb component against doxorubicin induced cardiomyocyte injury. Methods Myocardial cells isolated from the neonatal rats with hypoxia/reoxygenation injury of...
Chemical constituents and cytotoxic activities in breast cancer of Euphorbia ebracteolata
CAO Qingqing, LI Chengjian, LI Yunqing, GE Jiyun, CHEN Jun, ZHOU Jin, QIAN Xian, ZHAO Liang
2019, 37(4): 309-313,317. doi: 10.3969/j.issn.1006-0111.2019.04.005
Abstract:
Objective To investigate the chemical constituents and cytotoxic activities of breast cancer in the roots of Euphorbia ebracteolata. Methods The chemical constituents were isolated and purified by various chromatographic techniques.The in vitro cyt...
Study on the secondary metabolites of the fungus Chaetomium sp.
MENG Hui, XU Yong
2019, 37(4): 314-317. doi: 10.3969/j.issn.1006-0111.2019.04.006
Abstract(4398) PDF (947KB)(438)
Abstract:
Objective To investigate the secondary metabolites of the marine fungi Chaetomium sp. Methods The EtOAc extract of Chaetomium sp.fermentation was purified by repeated column chromatography on silica gel,Sephadex LH-20,and high-performance liquid ch...
Resources investigation and pharmacognostical identification on Abri Herba
XIAO Xiao, YAO Xiangcao, YU Yaru, XU Zhongyuan, HUANG Baokang
2019, 37(4): 318-321. doi: 10.3969/j.issn.1006-0111.2019.04.007
Abstract:
Objective To investigate the distribution of resources and pharmacognostical characteristics of Abri herba and provide scientific basis for the identification and utilization of Abri herba safely and rationally. Methods Through the literature sear...
Rapid identification of domestic and imported hops based on NIRS technology and PCA-SVM algorithm
GUO Yunxiang, CHEN Long, LI Xiaojin, WANG Guoping, JIANG Yiping, XIN Hailiang, JIA Xiaoguang
2019, 37(4): 322-331. doi: 10.3969/j.issn.1006-0111.2019.04.008
Abstract:
Objective To develop a rapid identification method for domestic and imported hops by the establishment of PCA-SVM model using near-infrared reflectance spectroscopy (NIRS),combined with principal component analysis (PCA) and support vector machine (...
Metabolomics study of Lysimachiae Herba on mice with crystallization kidney injury by GC-MS
DU Yi, DING Deying, LÜ Lei, LI Ling
2019, 37(4): 332-336. doi: 10.3969/j.issn.1006-0111.2019.04.009
Abstract:
Objective To evaluate therapeutic effects of Lysimachiae Herba for crystallization kidney injury with serum metabolomics method. Methods 21 rats were randomly divided into three groups including control group,crystallization kidney injury model gro...
The assay of three triterpenoid saponin extracted from Bessia calthaefolia simultaneously by HPLC-ELSD and their antioxidant effects in vitro
ZHOU Jing, YE Zhaohui, WU Yanhua
2019, 37(4): 337-341,347. doi: 10.3969/j.issn.1006-0111.2019.04.010
Abstract:
Objective To establish a method for simultaneous determination of three triterpenoid saponins (BeesiosideⅠ、Ⅱ、Ⅲ),and investigate antioxidant effects of triterpenoid saponin extracted from Bessia calthaefolia. Methods The content assay of triterpenoi...
The effect of triamcinolone acetonide delivered by microneedle roller on nude mouse model xenografted with human hypertrophic scar
ZHANG Juanjuan, YU Hai, WU Zhihong, XU Shun, ZHANG Lichao
2019, 37(4): 342-347. doi: 10.3969/j.issn.1006-0111.2019.04.011
Abstract:
Objective To investigate the effect of triamcinolone acetonide cream (TAC) delivered by microneedle roller on the treatment for human hypertrophic scar. Methods The model was established by xenografting human hypertrophic scar onto the back of nude...
Determination of content of α-Asarone in Piper sarmentosum Roxb.from different habitats by HPLC
LI Qing, HE Mingyue, QU Falin, TAN Xingqi, DONG Wenshen, NI Yujia, SHAO Liuying
2019, 37(4): 348-351. doi: 10.3969/j.issn.1006-0111.2019.04.012
Abstract:
Objective To determine the content of α-Asarone in Piper sarmentosum Roxb.from different habitats by HPLC. Methods The chromatographic column was Lichrospher C18 (150 mm×4.6 mm,5μm).The mobile phase was acetonitrile-0.05% H3PO4 solution (47:53) wit...
Determination for total flavonoids in compound Huanglian clysis
NI Xiaoxia, WANG Qingfen, LIU Xiaoling, YE Caifa
2019, 37(4): 352-356,374. doi: 10.3969/j.issn.1006-0111.2019.04.013
Abstract:
Objective To establish a method for the determination of the content of total flavonoids in compound Huanglian clysis. Methods Three reference substances and the three coloration methods were studied to find the ideal coloration method and determin...
Validation of microbial limit test for compound terbinafine gel
CHEN Jing, ZHONG Guixiang, YAN Jia, SONG Hongtao
2019, 37(4): 357-360,369. doi: 10.3969/j.issn.1006-0111.2019.04.014
Abstract:
Objective To establish a microbial limit test method for compound terbinafine gel. Methods The test was carried out according to the requirements of provision 1105,1106 and 1107 of rules of preparation in volume IV of Chinese pharmacopoeia 2015 edi...
Determination of dexamethasone sodium phosphate and ethylparaben in Zhiyang dishuang cream by HPLC of double wavelength
HAO Zhe, QIU Huiping, WANG Lijun, LIU Dong, SONG Yanli, WANG Weiqin, QU Jun
2019, 37(4): 361-364. doi: 10.3969/j.issn.1006-0111.2019.04.015
Abstract:
Objective To establish a double wavelength HPLC method for determination of dexamethasone sodium phosphate and ethylparaben in Zhiyang dishuang cream. Methods The HPLC method was adopted with the Wondasil C18(4.6 mm×250 mm,5 μm) and triethylamine s...
Pharmacological monitoring in a case of primary hepatocellular carcinoma with type 2 diabetes mellitus followed by hepatic abscess after radiofrequency ablation
WU Yimei, SHENG Yuehong, LIU Yi, XIE Congjing, GE Jiyun, HUANG Yufeng
2019, 37(4): 365-369. doi: 10.3969/j.issn.1006-0111.2019.04.016
Abstract:
Objective To investigate the pharmacological monitoring in a hepatic abscess patient after radiofrequency ablation for primary hepatocellular carcinoma with type 2 diabetes mellitus. Methods The patient's liver and kidney function were monitored to...
Pharmaceutical care of antithrombotic therapy for heparin-induced thrombocytopenia after percutaneous coronary intervention
GUAN Wenjie, CHEN Huihui, WANG Tao, ZHANG Chenchen, CHEN Yanjie, ZHU Jie
2019, 37(4): 370-374. doi: 10.3969/j.issn.1006-0111.2019.04.017
Abstract:
Objective To explore clinical pharmacists' role in antithrombotic therapy for acute myocardial infarction (AMI) inpatients with heparin-induced thrombocytopenia (HIT) after percutaneous coronary intervention (PCI). Methods Clinical pharmacists used...
A Meta-analysis on magnesium isoglycyrrhizinate in treatment of antituberculosis drug-induced liver injury
RUAN Jun, YIN Heng, KOU Guoxian, LIU Mingxin, YANG Ruixi
2019, 37(4): 375-379. doi: 10.3969/j.issn.1006-0111.2019.04.018
Abstract:
Objective To evaluate the therapeutic effects of magnesium isoglycyrrhizinate in patients with antituberculosis drug-induced liver injury. Methods The literatures related to randomized controlled trials (RCT) of magnesium isoglycyrrhizinate treatme...
Analysis of rational use of Chinese patent medicine in a hospital outpatient pharmacy in Shanghai from 2015 to 2017
JIANG Yin, YIN Cha
2019, 37(4): 380-384. doi: 10.3969/j.issn.1006-0111.2019.04.019
Abstract:
Objective To analyze the utilization of Chinese patent medicines in a hospital outpatient pharmacy in Shanghai and evaluate the effectiveness of measures to control the component ratio of the medications. Methods The sales volume and total cost of ...