2019 Vol. 37, No. 5
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2019, 37(5): 385-389,399.
doi: 10.3969/j.issn.1006-0111.2019.05.001
Abstract:
Metabolomics is a new science to quantitatively or qualitatively analyze all the endogenous small molecule metabolites in biological system(cells,tissues,organs,living organisms),which reveals the metabolic nature of diseases by studying the laws bet...
Metabolomics is a new science to quantitatively or qualitatively analyze all the endogenous small molecule metabolites in biological system(cells,tissues,organs,living organisms),which reveals the metabolic nature of diseases by studying the laws bet...
2019, 37(5): 390-393,421.
doi: 10.3969/j.issn.1006-0111.2019.05.002
Abstract:
Long non-coding RNA (lncRNA) covers most of the messages from the human DNA without protein-coding potential,which is a wide range of complicated molecules that consist of more than 90% of the whole genomic and present in different forms in the cours...
Long non-coding RNA (lncRNA) covers most of the messages from the human DNA without protein-coding potential,which is a wide range of complicated molecules that consist of more than 90% of the whole genomic and present in different forms in the cours...
2019, 37(5): 394-399.
doi: 10.3969/j.issn.1006-0111.2019.05.003
Abstract:
Biotechnology drugs have attracted increasing attention as a hot topic in research and development of new drugs.The pharmacokinetics of biotechnology drugs shows uniqueness and complexity due to the different physical and chemical properties from tho...
Biotechnology drugs have attracted increasing attention as a hot topic in research and development of new drugs.The pharmacokinetics of biotechnology drugs shows uniqueness and complexity due to the different physical and chemical properties from tho...
2019, 37(5): 400-405,426.
doi: 10.3969/j.issn.1006-0111.2019.05.004
Abstract:
Objective To investigate the effect of p62 protein on the lipid autophagy and the expression of inflammatory cytokines in macrophage-derived foam cells. Methods RAW264.7 cells were stimulated by oxidized low density lipoprotein to mimic the formati...
Objective To investigate the effect of p62 protein on the lipid autophagy and the expression of inflammatory cytokines in macrophage-derived foam cells. Methods RAW264.7 cells were stimulated by oxidized low density lipoprotein to mimic the formati...
2019, 37(5): 406-415.
doi: 10.3969/j.issn.1006-0111.2019.05.005
Abstract:
Objective To identify the chemical constituents in Fuzheng Huayu capsule by ultra performance liquid chromatography-high resolution time of flight mass spectrometry(UHPLC-TOF/MS). Methods ACQUITY UPLCHSS T3(2.1mm×100mm,1.8μm) was used to chromatogr...
Objective To identify the chemical constituents in Fuzheng Huayu capsule by ultra performance liquid chromatography-high resolution time of flight mass spectrometry(UHPLC-TOF/MS). Methods ACQUITY UPLCHSS T3(2.1mm×100mm,1.8μm) was used to chromatogr...
2019, 37(5): 416-421.
doi: 10.3969/j.issn.1006-0111.2019.05.006
Abstract:
Objective To study the effects of microneedle-roller insertion times on skin permeation. Methods Tretinoin was used as model drug.The in vitro transdermal characteristics in nude mice were studied with Franz diffusion cell and the tissue homogeniza...
Objective To study the effects of microneedle-roller insertion times on skin permeation. Methods Tretinoin was used as model drug.The in vitro transdermal characteristics in nude mice were studied with Franz diffusion cell and the tissue homogeniza...
2019, 37(5): 422-426.
doi: 10.3969/j.issn.1006-0111.2019.05.007
Abstract:
Objective To establish rat polycystic ovary syndrome model with letrozole combined high fat diet. Methods Eighteen 21-day-old female rats were fed with 45% high-fat diet for 16 weeks.Letrozole was started at the 6th week of age until the end of mod...
Objective To establish rat polycystic ovary syndrome model with letrozole combined high fat diet. Methods Eighteen 21-day-old female rats were fed with 45% high-fat diet for 16 weeks.Letrozole was started at the 6th week of age until the end of mod...
2019, 37(5): 427-432.
doi: 10.3969/j.issn.1006-0111.2019.05.008
Abstract:
Objective To investigate the correlation between anti-insomnia effects and HPLC fingerprint of compound caulis polygoni multiflori mixture. Methods A fingerprinting method was established by high performance liquid chromatography and then used to a...
Objective To investigate the correlation between anti-insomnia effects and HPLC fingerprint of compound caulis polygoni multiflori mixture. Methods A fingerprinting method was established by high performance liquid chromatography and then used to a...
2019, 37(5): 433-439.
doi: 10.3969/j.issn.1006-0111.2019.05.009
Abstract:
Objective To study the regulation and mechanism of hsa-miRNA-30a-5p on the proliferation of human lung cancer A549 cells. Methods Five pairs of lung cancer and para-carcinoma tissues were harvested in clinical and measured for hsa-miRNA-30a-5p and ...
Objective To study the regulation and mechanism of hsa-miRNA-30a-5p on the proliferation of human lung cancer A549 cells. Methods Five pairs of lung cancer and para-carcinoma tissues were harvested in clinical and measured for hsa-miRNA-30a-5p and ...
2019, 37(5): 440-443,449.
doi: 10.3969/j.issn.1006-0111.2019.05.010
Abstract:
Objective To investigate the physicochemical constants such as the solubility and the apparent oil-water partition coefficient of total flavonoids from Oxytropis falcata Bunge and study the in vitro percutaneous permeability for providing the refere...
Objective To investigate the physicochemical constants such as the solubility and the apparent oil-water partition coefficient of total flavonoids from Oxytropis falcata Bunge and study the in vitro percutaneous permeability for providing the refere...
2019, 37(5): 444-449.
doi: 10.3969/j.issn.1006-0111.2019.05.011
Abstract:
Objective The marine cyclopeptide stylissamide Ⅰ was synthesized through a solid phase synthesis and cyclization in solution(SPS-CS). Methods 2-chlorotrityl chloride resin was used as solid support for the total synthesis.Each amino acid protected ...
Objective The marine cyclopeptide stylissamide Ⅰ was synthesized through a solid phase synthesis and cyclization in solution(SPS-CS). Methods 2-chlorotrityl chloride resin was used as solid support for the total synthesis.Each amino acid protected ...
2019, 37(5): 450-452,480.
doi: 10.3969/j.issn.1006-0111.2019.05.012
Abstract:
Objective To establish a HPLC method for the assay of palmitul 3-(3,4-dihydroxyphenyl)-2-hydroxypropanoate (PDSS) in liposomes. Methods The separation was performed with an Agilent ZORBAX Eclipse Plus C18 column (4.6 mm×200 mm,5 μm) at room tempera...
Objective To establish a HPLC method for the assay of palmitul 3-(3,4-dihydroxyphenyl)-2-hydroxypropanoate (PDSS) in liposomes. Methods The separation was performed with an Agilent ZORBAX Eclipse Plus C18 column (4.6 mm×200 mm,5 μm) at room tempera...
2019, 37(5): 453-459.
doi: 10.3969/j.issn.1006-0111.2019.05.013
Abstract:
Objective To understand the research trends and hot issues of the research literature on the rational drug use of hypertension in Chinese hospital,and provide reference for promoting rational drug use of hypertension. Methods Literature of rational...
Objective To understand the research trends and hot issues of the research literature on the rational drug use of hypertension in Chinese hospital,and provide reference for promoting rational drug use of hypertension. Methods Literature of rational...
2019, 37(5): 460-463.
doi: 10.3969/j.issn.1006-0111.2019.05.014
Abstract:
Objective To establish an assay method for three flavonoid glycosides:kaempferol-3-O-L-rhamnopyranosyl(1→2)-β-D-glucopyranoside,kaempferol-3-O-glucoside and kaemperol-3-O-α-L-rhamnopyranosyl(1→2)-[6-O-acetyl]-β-D-glucopyranoside in Thesium chinensis...
Objective To establish an assay method for three flavonoid glycosides:kaempferol-3-O-L-rhamnopyranosyl(1→2)-β-D-glucopyranoside,kaempferol-3-O-glucoside and kaemperol-3-O-α-L-rhamnopyranosyl(1→2)-[6-O-acetyl]-β-D-glucopyranoside in Thesium chinensis...
2019, 37(5): 464-465,469.
doi: 10.3969/j.issn.1006-0111.2019.05.015
Abstract:
Objective To establish a method for determination of ethanol content in intermediate products during the production of blood products by GC. Methods DB-624 column was used with FID detection.The temperature of the injector and detector was 230℃,280...
Objective To establish a method for determination of ethanol content in intermediate products during the production of blood products by GC. Methods DB-624 column was used with FID detection.The temperature of the injector and detector was 230℃,280...
2019, 37(5): 466-469.
doi: 10.3969/j.issn.1006-0111.2019.05.016
Abstract:
Objective To analyze the participation effect of clinical pharmacist during the treatment process of sodium valproate in a patient with secondary epilepsy after stroke. Methods The correct dose and usage of sodium valproate under TDM,the most commo...
Objective To analyze the participation effect of clinical pharmacist during the treatment process of sodium valproate in a patient with secondary epilepsy after stroke. Methods The correct dose and usage of sodium valproate under TDM,the most commo...
2019, 37(5): 470-472.
doi: 10.3969/j.issn.1006-0111.2019.05.017
Abstract:
Objective To analyze the reason of gynecomastia in a male patient with heart failure and provide safer references for clinical prescriptions. Methods The patient's clinical symptoms,signs and laboratory findings in great detail were learned and the...
Objective To analyze the reason of gynecomastia in a male patient with heart failure and provide safer references for clinical prescriptions. Methods The patient's clinical symptoms,signs and laboratory findings in great detail were learned and the...
2019, 37(5): 473-480.
doi: 10.3969/j.issn.1006-0111.2019.05.018
Abstract:
Objective To evaluate the efficacy and safety of once-daily fluticasone furoate/vilanterol compared with ICS alone or twice-daily ICS/LABA formulations in patients with asthma. Methods Systematic search was performed for randomized controlled trial...
Objective To evaluate the efficacy and safety of once-daily fluticasone furoate/vilanterol compared with ICS alone or twice-daily ICS/LABA formulations in patients with asthma. Methods Systematic search was performed for randomized controlled trial...
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