DU Yi, DING Deying, LÜ Lei, LI Ling. Metabolomics study of Lysimachiae Herba on mice with crystallization kidney injury by GC-MS[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(4): 332-336. doi: 10.3969/j.issn.1006-0111.2019.04.009
| Citation:
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DU Yi, DING Deying, LÜ Lei, LI Ling. Metabolomics study of Lysimachiae Herba on mice with crystallization kidney injury by GC-MS[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(4): 332-336. doi: 10.3969/j.issn.1006-0111.2019.04.009
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Metabolomics study of Lysimachiae Herba on mice with crystallization kidney injury by GC-MS
- 1.
Department of Pharmacy, Xinhua Hospital Affiliated to School of Medicine, Shanghai Jiaotong University, Shanghai 200092, China
- 2.
Pharmaceutical Analysis Center, School of Pharmacy, Naval Medical University, Shanghai 200433, China
- 3.
Department of Pharmacy, Shanghai Eastern Hepatobiliary Surgery Hospital, Shanghai 200438, China
- Received Date: 2018-12-13
- Rev Recd Date:
2019-05-07
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Abstract
Objective To evaluate therapeutic effects of Lysimachiae Herba for crystallization kidney injury with serum metabolomics method. Methods 21 rats were randomly divided into three groups including control group,crystallization kidney injury model group and Lysimachiae Herba-treated group.The medicated group received Lysimachiae Herba for 6 days.Then,the serum samples of each rat were collected and analyzed by Gas Chromatography-Mass Spectrometer (GC-MS).The pattern recognition analysis of metabolomics differences among three groups was used to evaluate therapeutic effects of Lysimachiae Herba. Results 14 metabolites were identified through serum metabolomics analysis.The possible mechanism of crystallization kidney injury was mainly related to the metabolic products of purine,amino acid,fatty acid and sugar.The kidney injury by crystallization was alleviated by Lysimachiae Herba. Conclusion Lysimachiae Herba has preventive and therapeutic effects for crystallization kidney injury through partially regulating the perturbed purine metabolism,amino acid metabolism and glycometabolism.
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References
|
[1]
|
简宇,马进.慢性肾衰竭中西医治疗进展[J].辽宁中医药大学学报,2014,16(11):198-201. |
|
[2]
|
李昕.慢性肾功能衰竭并发症的研究进展[J].医学信息:中旬刊,2010,5(5):1334. |
|
[3]
|
李飞艳,周日宝,刘群群.金钱草及其混伪品的微性状鉴定[J].海峡药学,2018,30(7):39-41. |
|
[4]
|
武维波,刘永,刘桂营.利尿排石汤治疗泌尿系结石780例[J].实用中医药杂志,2013,29(7):559. |
|
[5]
|
赵建一.金钱草治疗尿结石的机理作用研究[J].中医临床研究,2013,5(16):37-38. |
|
[6]
|
GUO L,TAN G G,LIU P,et al.Three plasma metabolite signatures for diagnosing high altitude pulmonary edema[J].Sci Rep,2015,5:15126. |
|
[7]
|
BIJLSMA S,BOBELDIJK I,VERHEIJ E R,et al.Large-scale human metabolomics studies:A strategy for data (pre-) processing and validation[J].Anal Chem,2006,78(2):567-574. |
|
[8]
|
EDVARDSSON V O,INDRIDASON O S,HARALDSSON G,et al.Temporal trends in the incidence of kidney stone disease[J].Kidney Int,2013,83(1):146-152. |
|
[9]
|
彭明,顾向明,杜国有,等.泌尿系结石患者血清胱抑素C的含量变化分析[J].检验医学与临床,2011,8(2):172-173. |
|
[10]
|
ZAKARIA F A.Effect of oxygen derived free radicals and glycine on sodium-potassium adenosine triphosphatase in the basolateral membrane of the kidney in ischemia-reperfusion[J].Saudi Med J,2002,23(11):1380-1385. |
|
[11]
|
GARIBOTTO G,BONANNI A,VERZOLA D.Effect of kidney failure and hemodialysis on protein and amino acid metabolism[J].Curr Opin Clin Nutr Metab Care,2012,15(1):78-84. |
|
[12]
|
张珺,尹磊,王昭君,等.脓毒症相关性肾损伤临床特征及预后分析[J].宁夏医学杂志,2018,40(9):807-809. |
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