2018 Vol. 36, No. 2
Display Method:
2018, 36(2): 97-102.
doi: 10.3969/j.issn.1006-0111.2018.02.001
Abstract:
Network pharmacology is the basis of system biology, systematically expounded the interaction of the principle and regulation between body and the drug, representing the idea of the modern biomedical philosophy and researching model. It could be more...
Network pharmacology is the basis of system biology, systematically expounded the interaction of the principle and regulation between body and the drug, representing the idea of the modern biomedical philosophy and researching model. It could be more...
2018, 36(2): 103-107,130.
doi: 10.3969/j.issn.1006-0111.2018.02.002
Abstract:
Antiangiogenic target therapy has been a hot topic in cancer treatment recently. Apatinib is a category 1.1 new medication developed domestically. It effectively inhibits angiogenic and exhibits promising anti-tumor activity in preclinical studies. A...
Antiangiogenic target therapy has been a hot topic in cancer treatment recently. Apatinib is a category 1.1 new medication developed domestically. It effectively inhibits angiogenic and exhibits promising anti-tumor activity in preclinical studies. A...
2018, 36(2): 108-111.
doi: 10.3969/j.issn.1006-0111.2018.02.003
Abstract:
Tanshinone ⅡA is a kind of phenanthraquinone derivatives derived from Salvia miltiorrhiza, which is one of the main active components of Danshen to play the protective role of cerebral ischemic injury. Inflammation plays an important role in the path...
Tanshinone ⅡA is a kind of phenanthraquinone derivatives derived from Salvia miltiorrhiza, which is one of the main active components of Danshen to play the protective role of cerebral ischemic injury. Inflammation plays an important role in the path...
2018, 36(2): 112-115,135.
doi: 10.3969/j.issn.1006-0111.2018.02.004
Abstract:
Objective To design and synthesize schisandrone derivatives for the therapy of disease like AD,and to measure their anti-oxidation activity. Methods Ten compounds were synthesized,and seven of them were first reported.The influence all the compoun...
Objective To design and synthesize schisandrone derivatives for the therapy of disease like AD,and to measure their anti-oxidation activity. Methods Ten compounds were synthesized,and seven of them were first reported.The influence all the compoun...
2018, 36(2): 116-120.
doi: 10.3969/j.issn.1006-0111.2018.02.005
Abstract:
Objective To perform the ligand-based computer-aided drug design and construct the pharmacophore model of (1,3)-β-D-Glucan Synthase (GS) small molecule inhibitors. Method Six small molecules with diverse structures and good inhibitory activity wer...
Objective To perform the ligand-based computer-aided drug design and construct the pharmacophore model of (1,3)-β-D-Glucan Synthase (GS) small molecule inhibitors. Method Six small molecules with diverse structures and good inhibitory activity wer...
2018, 36(2): 121-125.
doi: 10.3969/j.issn.1006-0111.2018.02.006
Abstract:
Objective To study the extraction technology and optimize the extraction process of Fuyuan Xingnao granule. Methods The preliminary extraction process was designed by routine extraction method combined with the results of pharmacological activity ...
Objective To study the extraction technology and optimize the extraction process of Fuyuan Xingnao granule. Methods The preliminary extraction process was designed by routine extraction method combined with the results of pharmacological activity ...
2018, 36(2): 126-130.
doi: 10.3969/j.issn.1006-0111.2018.02.007
Abstract:
Objective To evaluate the regulation of the TRPV1 receptor on the expression of EGFR protein and the effects on related cell functions. Methods Human pancreatic cancer cells PANC-1 were cultured and treated by over-expression and siRNA. Cell proli...
Objective To evaluate the regulation of the TRPV1 receptor on the expression of EGFR protein and the effects on related cell functions. Methods Human pancreatic cancer cells PANC-1 were cultured and treated by over-expression and siRNA. Cell proli...
2018, 36(2): 131-135.
doi: 10.3969/j.issn.1006-0111.2018.02.008
Abstract:
Objective To investigate the effects of combination therapy with ACEI and aldosterone receptor antagonist on Cys-C and urinary microprotein regulation. Methods Patients were randomly divided into two groups. The control group received benazepine h...
Objective To investigate the effects of combination therapy with ACEI and aldosterone receptor antagonist on Cys-C and urinary microprotein regulation. Methods Patients were randomly divided into two groups. The control group received benazepine h...
2018, 36(2): 136-139,146.
doi: 10.3969/j.issn.1006-0111.2018.02.009
Abstract:
Objective To compare the renal toxicity of vancomycin with continuous infusion vs intermittent infusion. Methods The databases of EMBASE, PUBMED, the Cochrane Register of Controlled Trials, CBM, CNKI and WanFang were searched. The Cochrane Revman5...
Objective To compare the renal toxicity of vancomycin with continuous infusion vs intermittent infusion. Methods The databases of EMBASE, PUBMED, the Cochrane Register of Controlled Trials, CBM, CNKI and WanFang were searched. The Cochrane Revman5...
2018, 36(2): 140-146.
doi: 10.3969/j.issn.1006-0111.2018.02.010
Abstract:
Objective To explore the licorice herbs principal component isomer content and percentage change in different processing and extracting conditions. Methods RP-HPLC method were used with 18 beta glycyrrhizic acid (18β-Gly) and 18 alpha glycyrrhizic...
Objective To explore the licorice herbs principal component isomer content and percentage change in different processing and extracting conditions. Methods RP-HPLC method were used with 18 beta glycyrrhizic acid (18β-Gly) and 18 alpha glycyrrhizic...
2018, 36(2): 147-155.
doi: 10.3969/j.issn.1006-0111.2018.02.011
Abstract:
Objective To compare the cost-effectiveness of Danshenchuanxiongqin injection versus salvianolate injection for angina pectoris. Methods Databases including CBM, CNKI, VIP, Cochrane library, Pubmed, Embase and Wanfang were electronically searched ...
Objective To compare the cost-effectiveness of Danshenchuanxiongqin injection versus salvianolate injection for angina pectoris. Methods Databases including CBM, CNKI, VIP, Cochrane library, Pubmed, Embase and Wanfang were electronically searched ...
2018, 36(2): 156-161.
doi: 10.3969/j.issn.1006-0111.2018.02.012
Abstract:
Objective To establish the quality control method for Huoguwan. Methods TLC was applied to detect the component of Danshen, Dihuang, Danggui, Chuanxiong, Sanqi, Tubiechong, and Zhicaowu in this compound preparation. HPLC was used to measure the co...
Objective To establish the quality control method for Huoguwan. Methods TLC was applied to detect the component of Danshen, Dihuang, Danggui, Chuanxiong, Sanqi, Tubiechong, and Zhicaowu in this compound preparation. HPLC was used to measure the co...
2018, 36(2): 162-165,169.
doi: 10.3969/j.issn.1006-0111.2018.02.013
Abstract:
Objective To improve the quality standard of Taohong Tongmai granule. Methods TLC was used to make qualitative identification of Paeoniae Radix Rubra,Rehmanniae Radix,Glycyrrhizae Radix; The effective components of the main walnut kernel were iden...
Objective To improve the quality standard of Taohong Tongmai granule. Methods TLC was used to make qualitative identification of Paeoniae Radix Rubra,Rehmanniae Radix,Glycyrrhizae Radix; The effective components of the main walnut kernel were iden...
2018, 36(2): 166-169.
doi: 10.3969/j.issn.1006-0111.2018.02.014
Abstract:
Objective To evaluate and analyze the drug-drug interactions (DDI) of different antidiabetic drugs. Methods DDI database Lexi-InteractionTM was used to evaluate DDI for 28 commonly used antidiabetic medications (including insulin and 27 non-insuli...
Objective To evaluate and analyze the drug-drug interactions (DDI) of different antidiabetic drugs. Methods DDI database Lexi-InteractionTM was used to evaluate DDI for 28 commonly used antidiabetic medications (including insulin and 27 non-insuli...
2018, 36(2): 170-172,179.
doi: 10.3969/j.issn.1006-0111.2018.02.015
Abstract:
Objective To investigate the structure and optical activity of flavonoid derivative:2-(3,4-dimethoxyphenyl) -4-oxo-4H-chromen-3-yl acetate ( 4 ). Methods The absolute configuration was obtained by X-ray single crystal diffraction. The optical rota...
Objective To investigate the structure and optical activity of flavonoid derivative:2-(3,4-dimethoxyphenyl) -4-oxo-4H-chromen-3-yl acetate ( 4 ). Methods The absolute configuration was obtained by X-ray single crystal diffraction. The optical rota...
2018, 36(2): 173-175.
doi: 10.3969/j.issn.1006-0111.2018.02.016
Abstract:
Objective To optimize the extraction process and improve the quality of Toufu irrigation. Methods Matrine assay was selected to be the indicator for the extraction efficacy. Orthogonal test was used to determine the optimal water amount, extractio...
Objective To optimize the extraction process and improve the quality of Toufu irrigation. Methods Matrine assay was selected to be the indicator for the extraction efficacy. Orthogonal test was used to determine the optimal water amount, extractio...
2018, 36(2): 176-179.
doi: 10.3969/j.issn.1006-0111.2018.01.017
Abstract:
Objective To evaluate the cost-effectiveness of two chemotherapy regimens in NSCLC for the purpose of lower cost, higher quality medical care. Methods 56 patients with advanced NSCLC were divided into two groups from our hospital, group PP (pemtre...
Objective To evaluate the cost-effectiveness of two chemotherapy regimens in NSCLC for the purpose of lower cost, higher quality medical care. Methods 56 patients with advanced NSCLC were divided into two groups from our hospital, group PP (pemtre...
2018, 36(2): 180-182.
doi: 10.3969/j.issn.1006-0111.2018.02.018
Abstract:
Objective To explore the application of mixed anesthesia with epinephrine hydrochloride and lidocaine in senile ptosis surgery. Methods 90 senile ptosis cases (180 eyes) treated from January 2016 to June 2016 were randomly divided into experimenta...
Objective To explore the application of mixed anesthesia with epinephrine hydrochloride and lidocaine in senile ptosis surgery. Methods 90 senile ptosis cases (180 eyes) treated from January 2016 to June 2016 were randomly divided into experimenta...
2018, 36(2): 183-185.
doi: 10.3969/j.issn.1006-0111.2018.02.019
Abstract:
Objective To observe the effectiveness and safeness of granulocyte macrophage colony stimulating factor(GM-CSF) and whole lung lavage therapy for patients with idiopathic pulmonary alveolar proteinosis (IPAP). Methods Two IPAP patients who were ho...
Objective To observe the effectiveness and safeness of granulocyte macrophage colony stimulating factor(GM-CSF) and whole lung lavage therapy for patients with idiopathic pulmonary alveolar proteinosis (IPAP). Methods Two IPAP patients who were ho...
2018, 36(2): 186-188,191.
doi: 10.3969/j.issn.1006-0111.2018.02.020
Abstract:
Objective To study the features, general patterns and predisposing factors of adverse drug reactions (ADR) occurred in our hospital and to provide the guidance for rational and safe use of drugs in clinic. Methods 302 cases of ADR were reported fr...
Objective To study the features, general patterns and predisposing factors of adverse drug reactions (ADR) occurred in our hospital and to provide the guidance for rational and safe use of drugs in clinic. Methods 302 cases of ADR were reported fr...
2018, 36(2): 189-191.
doi: 10.3969/j.issn.1006-0111.2018.02.021
Abstract:
Objective To compare three different anti-hypertension therapeutic projects by pharmacoeconomic evaluation and to find out the best therapeutic project. Methods Retrospective study was used.120 patients with hypertension were randomly assigned to ...
Objective To compare three different anti-hypertension therapeutic projects by pharmacoeconomic evaluation and to find out the best therapeutic project. Methods Retrospective study was used.120 patients with hypertension were randomly assigned to ...
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