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心肌缺血的昼夜节律性与时辰疗法

张恩晖,  王海峰,  陈莉,  刘佃花,  于剑光,  蔡国君

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文章导航 > 药学实践与服务  > 2016 >  34(1): 8-11,47
张恩晖, 王海峰, 陈莉, 刘佃花, 于剑光, 蔡国君. 心肌缺血的昼夜节律性与时辰疗法[J]. 药学实践与服务, 2016, 34(1): 8-11,47. doi: 10.3969/j.issn.1006-0111.2016.01.003
引用本文: 张恩晖, 王海峰, 陈莉, 刘佃花, 于剑光, 蔡国君. 心肌缺血的昼夜节律性与时辰疗法[J]. 药学实践与服务, 2016, 34(1): 8-11,47. doi: 10.3969/j.issn.1006-0111.2016.01.003
shu
ZHANG Enhui, WANG Haifeng, CHEN Li, LIU Dianhua, YU Jianguang, CAI Guojun. Circadian rhythms of myocardial ischemia and chronotherapy[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(1): 8-11,47. doi: 10.3969/j.issn.1006-0111.2016.01.003
Citation: ZHANG Enhui, WANG Haifeng, CHEN Li, LIU Dianhua, YU Jianguang, CAI Guojun. Circadian rhythms of myocardial ischemia and chronotherapy[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(1): 8-11,47. doi: 10.3969/j.issn.1006-0111.2016.01.003
shu

心肌缺血的昼夜节律性与时辰疗法

doi: 10.3969/j.issn.1006-0111.2016.01.003
  • 1.

    第二军医大学药学院药理学教研室, 上海 200433;解放军203医院药械科, 黑龙江 齐齐哈尔 161000

  • 2.

    解放军203医院药械科, 黑龙江 齐齐哈尔 161000

  • 3.

    第二军医大学药学院药理学教研室, 上海 200433

Circadian rhythms of myocardial ischemia and chronotherapy

  • 1.

    Department of Pharmacology, School of Pharmacy, the Second Military Medical University, Shanghai 200433, China;Department of Pharmacy and Equipment, No.203 Hospital of PLA, Qiqihar, 161000, China

  • 2.

    Department of Pharmacy and Equipment, No.203 Hospital of PLA, Qiqihar, 161000, China

  • 3.

    Department of Pharmacology, School of Pharmacy, the Second Military Medical University, Shanghai 200433, China

  • 摘要: 临床上心肌缺血(MI)的发作频率伴有昼夜变化,在清晨和傍晚是发病高峰期。产生这一现象主要是受到机体病理生理机制的昼夜节律性以及外界的环境因素影响。目前β-受体阻断剂、硝酸酯类以及钙通道阻滞剂等药物的治疗作用已经被证明受到机体昼夜节律的影响。因此,笔者对MI发作的昼夜节律特点、病理生理机制以及目前临床上的时辰疗法进行综述,并对未来的治疗策略进行探讨。
    Abstract: The occurrence of the clinical manifestations of myocardial ischemia shows clear circadian rhythmicity, and they are unevenly distributed during the 24 h with higher morbidity during the initial hours of the daily activity span and in the late afternoon or early evening. Such temporal patterns result from circadian rhythms in pathophysiological mechanisms plus cyclic environmental stressors that trigger these clinical events. β-receptor antagonist medications, oral nitrate, and calcium channel blocker have been shown to be influenced by the circadian time of their administration. Here we briefly review the characteristics of circadian rhythmicity in MI, the pathophysiological mechanisms as well as the current chronotherapy,and then discuss the future treatment strategies.
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  • 收稿日期:  2014-09-19
  • 修回日期:  2015-04-28

心肌缺血的昼夜节律性与时辰疗法

doi: 10.3969/j.issn.1006-0111.2016.01.003
  • 1. 第二军医大学药学院药理学教研室, 上海 200433;解放军203医院药械科, 黑龙江 齐齐哈尔 161000
  • 2. 解放军203医院药械科, 黑龙江 齐齐哈尔 161000
  • 3. 第二军医大学药学院药理学教研室, 上海 200433
  • 收稿日期: 2014-09-19
  • 修回日期: 2015-04-28

摘要: 临床上心肌缺血(MI)的发作频率伴有昼夜变化,在清晨和傍晚是发病高峰期。产生这一现象主要是受到机体病理生理机制的昼夜节律性以及外界的环境因素影响。目前β-受体阻断剂、硝酸酯类以及钙通道阻滞剂等药物的治疗作用已经被证明受到机体昼夜节律的影响。因此,笔者对MI发作的昼夜节律特点、病理生理机制以及目前临床上的时辰疗法进行综述,并对未来的治疗策略进行探讨。

English Abstract

张恩晖, 王海峰, 陈莉, 刘佃花, 于剑光, 蔡国君. 心肌缺血的昼夜节律性与时辰疗法[J]. 药学实践与服务, 2016, 34(1): 8-11,47. doi: 10.3969/j.issn.1006-0111.2016.01.003
引用本文: 张恩晖, 王海峰, 陈莉, 刘佃花, 于剑光, 蔡国君. 心肌缺血的昼夜节律性与时辰疗法[J]. 药学实践与服务, 2016, 34(1): 8-11,47. doi: 10.3969/j.issn.1006-0111.2016.01.003
shu
ZHANG Enhui, WANG Haifeng, CHEN Li, LIU Dianhua, YU Jianguang, CAI Guojun. Circadian rhythms of myocardial ischemia and chronotherapy[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(1): 8-11,47. doi: 10.3969/j.issn.1006-0111.2016.01.003
Citation: ZHANG Enhui, WANG Haifeng, CHEN Li, LIU Dianhua, YU Jianguang, CAI Guojun. Circadian rhythms of myocardial ischemia and chronotherapy[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(1): 8-11,47. doi: 10.3969/j.issn.1006-0111.2016.01.003
shu

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