甲状旁腺素和甲状旁腺素相关肽在皮肤病中的研究进展

卜晓琳; 毕新岭; 徐晓光; 高志祥; 李慧; 顾军

doi:10.3969/j.issn.1006-0111.2014.06.002

甲状旁腺素和甲状旁腺素相关肽在皮肤病中的研究进展

doi: 10.3969/j.issn.1006-0111.2014.06.002

1.
上海市浦东新区公利医院皮肤科, 上海 200135;第二军医大学附属长海医院皮肤科, 上海 200433
2.
第二军医大学附属长海医院皮肤科, 上海 200433

基金项目: 浦东新区卫生系统优秀青年医学人才培养计划(PWRq2013-02).

The research progress of parathyroid hormone and parathyroid hormone-related peptide in skin disease

1.
Department of Dermatology, Shanghai Pudong New Area Gongli Hospital, Shanghai 200135, China;Department of Dermatology, Changhai Hospital affiliated to Secend Military Medical University, Shanghai 200433, China
2.
Department of Dermatology, Changhai Hospital affiliated to Secend Military Medical University, Shanghai 200433, China

摘要: 甲状旁腺素(PTH)和甲状旁腺素相关肽(PTHrP)是一类多肽类激素,它们具有相似的基因结构、相同的膜受体,在人体钙、磷代谢过程中起着重要的调节作用。PTH和PTHrP及其受体除表达于肿瘤组织外,在皮肤、毛囊等正常组织也有表达。它们对表皮增殖分化、毛发生长的生理作用等方面,有望成为银屑病等常见皮肤病的治疗新靶点。
- 甲状旁腺素 /
- 甲状旁腺素相关肽 /
- 皮肤病
Abstract: Parathyroid hormone/parathyroid hormone-related peptides are polypeptide hormones. They have similar gene structure and same membrane receptor. They play great roles in regulating the calcium and phosphorus metabolism in vivo. PTH/PTHrP and their receptors are expressed in tissues of tumor,skin, hair follicle and other normal tissues. Because of their physiological action on the proliferation and differentiation of epidermis and hair growth,they may be a potential therapeutic target for some skin diseases including psoriasis.
- parathyroid hormone /
- parathyroid hormone-related peptide /
- skin disease

[1]	Oquendo M, Abramovits W, Morrell P.Topical vitamin D analogs available to treat psoriasis[J]. Skin Med, 2012,10(6):356-360.
[2]	Shah KN.Diagnosis and treatment of pediatric psoriasis: current and future[J]. Am J Clin Dermatol,2013,14(3):195-213.
[3]	Holick MF. Clinical efficacy of 1,25-dihydroxyvitamin D₃ and its analogues in the treatment of psoriasis[J]. Retinoids,1998,14: 12-17.
[4]	Cupp ME, Nayak SK, Adem AS, et al.Parathyroid hormone (PTH) and PTH-related peptide domains contributing to activation of different PTH receptor-mediated signaling pathways[J]. J Pharmacol Exp Ther,2013,345(3):404-418.
[5]	Whitfield JF, Isaacs RJ, Chakravarthy B, et al.Stimulation of protein kinase C activity in cells expressing human parathyroid hormone receptors by C-and N-terminally truncated fragments of parathyroid hormone 1-34[J]. J Bone Miner Res, 2001,16(3):441-447.
[6]	Strewler GJ,Nissenson RA.Hypercalcemia in malignancy[J]. West J Med,1990,153(6):635-640.
[7]	Wysolmerski JJ, Broadus AE.Hypercalcemia of malignancy: the central role of parathyroid hormone-related protein[J]. Annu Rev Med, 1994,45:189-200.
[8]	Strewler GJ. The parathyroid hormone-related protein[J]. Endocrinol Metab Clin North Am, 2000,29(3):629-645.
[9]	Milanesi A, Yu R, Wolin EM.Humoral hypercalcemia of malignancy caused by parathyroid hormone-related peptide-secreting neuroendocrine tumors: report of six cases[J]. Pancreatology, 2013,13(3):324-326.
[10]	Nilubol N, Weisbrod AB, Weinstein LS,et al.Utility of intraoperative parathyroid hormone monitoring in patients with multiple endocrine neoplasia type 1-associated primary hyperparathyroidism undergoing initial parathyroidectomy[J]. World J Surg,2013,37(8):1966-1972.
[11]	Hiremath M, Wysolmerski J.Parathyroid hormone-related protein apecifies the mammary mesenchyme and regulates embryonic mammary sevelopment[J]. J Mamm Gland Biol Neopl,2013,18(2):171-177.
[12]	Jia T, Qureshi AR, Brandenburg V,et al.Determinants of dibroblast growth dactor-23 and parathyroid hormone variability in dialysis patients[J]. Am J Nephrol, 2013,37(5):462-471.
[13]	Metzger M, Houillier P, Gauci C, et al.Relation between circulating levels of 25(OH) vitamin D and parathyroid hormone in chronic kidney disease: quest for a threshold[J].J Clin Endocrinol Metab,2013,98(7):2922-2928.
[14]	Urea P.The PTH/PTHrP receptor: biological implications[J].Nefrologia,2003,23(Suppl 2):12-17.
[15]	Errazahi A, Bouizar Z, Lieberherr M,et al.Functional type I PTH/PTHrP receptor in freshly isolated newborn rat keratinocytes: identification by RT-PCR and immunohistochemistry[J].J Bone Miner Res, 2003,18(4):737-750.
[16]	Calvi LM, Adams GB, Weibrecht KW,et al. Osteoblastic cells regulate the haematopoietic stem cell niche[J].Nature, 2003,425(6960):841-846.
[17]	Weber JM, Adams GB, Guaman ML, et al. Parathyroid treatment improves survival after bone marrow transplantation and increases osteoblastic expression of the Notch ligand Jagged 1[J].J Bone Miner Res,2004,19:S407.
[18]	Aho S.Soluble form of Jagged1: unique product of epithelial keratinocytes and a regulator of keratinocyte differentiation[J].J Cell Biochem, 2004,92(6):1271-1281.
[19]	Holick MF, Nussbaum S, Persons KS. PTH-like humoral hypercalcemia factor (HHF) of malignancy may be an epidermal differentiation factor:synthetic hHHF(1-34) NH₂ inhibits proliferation and induces terminal differentiation of cultured human kerationcytes[J].J Bone Miner Res,1988,3:S214.
[20]	Hanafin NM, Chen TC, Heinrich G,et al.Cultured human fibroblasts and not cultured human keratinocytes express a PTH/PTHrP receptor mRNA[J].J Invest Dermatol,1995,105(1):133-137.
[21]	Whitfield JF.Taming psoriatic keratinocytes-PTHs'uses go up another notch[J].J Cell Biochem,2004,93(2):251-256.
[22]	KaiserSM, Sebag M, Rhim JS,et al.Antisense-mediated inhibition of parathyroid hormone-related peptide production in a keratinocyte cell line impedes differentiation[J].Mol Endocrinol,1994,8(2):139-147.
[23]	Juhlin L, Hagforsen E, Juhlin C.Parathyroid hormone related protein is localized in the granular layer of normal skin and in the dermal infiltrates of mycosis fungoides but is absent in psoriatic lesions[J].Acta Derm Venereol,1992,72(2):81-83.
[24]	Whitfield JF, Chakravarthy BR, Durkin JP,et al.Parathyroid hormone stimulates protein kinase C but not adenylate cyclase in mouse epidermal keratinocytes[J].J Cell Physiol, 1992,150(2):299-303.
[25]	Dore RK.Long-term safety, efficacy, and patient acceptability of teriparatide in the management of glucocorticoid-induced osteoporosis[J].Patient Prefer Adher, 2013,7:435-446.
[26]	Horwitz MJ, Augustine M, Kahn L,et al.A comparison of parathyroid hormone-related protein (1-36) and parathyroid hormone (1-34) on markers of bone turnover and bone density in postmenopausal women: the PrOP study[J].J Bone Miner Res, 2013,28(11):2266-2276.
[27]	Holick MF, Chimeh FN, Ray S.Topical PTH (1-34) is a novel, safe and effective treatment for psoriasis: a randomized self-controlled trial and an open trial[J].Br J Dermatol, 2003,149(2):370-376.
[28]	Peters EM, Foitzik K, Paus R,et al.A new strategy for modulating chemotherapy-induced alopecia, using PTH/PTHrP receptor agonist and antagonist[J].J Invest Dermatol, 2001,117(2):173-178.

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甲状旁腺素和甲状旁腺素相关肽在皮肤病中的研究进展

doi: 10.3969/j.issn.1006-0111.2014.06.002

The research progress of parathyroid hormone and parathyroid hormone-related peptide in skin disease

计量

甲状旁腺素和甲状旁腺素相关肽在皮肤病中的研究进展

doi: 10.3969/j.issn.1006-0111.2014.06.002

1. 上海市浦东新区公利医院皮肤科, 上海 200135;第二军医大学附属长海医院皮肤科, 上海 200433

2. 第二军医大学附属长海医院皮肤科, 上海 200433

English Abstract

The research progress of parathyroid hormone and parathyroid hormone-related peptide in skin disease

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甲状旁腺素和甲状旁腺素相关肽在皮肤病中的研究进展

doi: 10.3969/j.issn.1006-0111.2014.06.002

The research progress of parathyroid hormone and parathyroid hormone-related peptide in skin disease

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甲状旁腺素和甲状旁腺素相关肽在皮肤病中的研究进展

doi: 10.3969/j.issn.1006-0111.2014.06.002

1. 上海市浦东新区公利医院皮肤科, 上海 200135;第二军医大学附属长海医院皮肤科, 上海 200433 2. 第二军医大学附属长海医院皮肤科, 上海 200433

English Abstract

The research progress of parathyroid hormone and parathyroid hormone-related peptide in skin disease

全文HTML

目录

1. 上海市浦东新区公利医院皮肤科, 上海 200135;第二军医大学附属长海医院皮肤科, 上海 200433

2. 第二军医大学附属长海医院皮肤科, 上海 200433