他汀类药物多效药理作用及其机制研究进展

赵心彬; 倪敏; 陶霞

doi:10.3969/j.issn.1006-0111.2013.01.005

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他汀类药物多效药理作用及其机制研究进展

赵心彬, 倪敏, 陶霞

文章导航 > 药学实践与服务 > 2013 > 31(1): 19-21

赵心彬, 倪敏, 陶霞. 他汀类药物多效药理作用及其机制研究进展[J]. 药学实践与服务, 2013, 31(1): 19-21. doi: 10.3969/j.issn.1006-0111.2013.01.005

引用本文:

赵心彬, 倪敏, 陶霞. 他汀类药物多效药理作用及其机制研究进展[J]. 药学实践与服务, 2013, 31(1): 19-21. doi: 10.3969/j.issn.1006-0111.2013.01.005

ZHAO Xin-bin, NI Min, TAO Xia. Progress on the multiple pharmacological activity and mechanism of statins[J]. Journal of Pharmaceutical Practice and Service, 2013, 31(1): 19-21. doi: 10.3969/j.issn.1006-0111.2013.01.005

Citation:

ZHAO Xin-bin, NI Min, TAO Xia. Progress on the multiple pharmacological activity and mechanism of statins[J]. Journal of Pharmaceutical Practice and Service, 2013, 31(1): 19-21. doi: 10.3969/j.issn.1006-0111.2013.01.005

他汀类药物多效药理作用及其机制研究进展

doi: 10.3969/j.issn.1006-0111.2013.01.005

第二军医大学长征医院药学部, 上海 200003

Progress on the multiple pharmacological activity and mechanism of statins

Department of Pharmacy, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China

摘要: 他汀类是临床上治疗高胆固醇血症主要药物, 广泛应用于冠心病一级及二级预防。近年来研究表明,他汀类药物还具有降脂外的多重作用,包括改善血管内皮功能、抗炎症、抗氧化作用、稳定动脉粥样硬化和抗肿瘤作用等。本文围绕他汀类药物对血管疾病和肿瘤的作用及机制展开综述。
- 他汀类药物 /
- 血管疾病 /
- 肿瘤
Abstract: Statins were a mainstay in the treatment of hyperlipidemia and used in the primary and secondary prevention of coronary artery disease. Recent studies indicated that there were some cholesterol-independent or pleiotropic effects of statins, including improving endothelial function, decreasing oxidative stress, inhibiting inflammation, enhancing the stability of atherosclerotic plaques and used for anticancer therapy. The effects and mechanisms of statins on vascular disease and cancer were reviewed in this paper.
- statins /
- vascular disease /
- cancer

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