银杏叶鼻用原位凝胶的制备及体外吸收研究
Studies of preparation and in vitro Absorption of ginkgo biloba leaf in-situ nasal gel
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摘要: 目的: 制备银杏叶鼻用原位凝胶剂,并考察促渗剂对银杏叶透黏膜吸收作用。 方法: 以卡波姆934、HPMC为凝胶基质制备pH敏感型鼻用原位凝胶剂,对粘度、粘附性及药物离体透黏膜吸收进行研究。 结果: 0.8%卡波姆934和1.5%HPMC可制备原位凝胶。3种促渗剂黏膜渗透速率为:1%氮酮>1%吐温>0.5%冰片。随氮酮浓度的增大,药物黏膜吸收逐渐增加,吸收过程符合Weibull动力学方程。 结论: 本银杏叶鼻用原位凝胶剂制备工艺可行,氮酮能有效地促进银杏叶的鼻腔吸收。Abstract: Objective To preparation of ginkgo biloba leaf in-situ nasal gel and exploration of the effect of sorbefacients on nasal mucosa Absorption. Methods Carbopol 934 and HPMC were used as gel matrix to prepare pH sensitive in-situ ginkgo biloba leaf nasal gel,whose viscosity,adhesion,and in vitro nasal mucosa Absorption were studied. Results The in-situ ginkgo biloba leaf gel can be best prepared with 0.8% of Carbopol 934 and 1.5% of HPMC as gel matrix.Three sorbefacients were studied.The sequence of their permeation rate were 1% of Azone > 1% of Twain-80 > 0.5% of Borneol.The drug Absorption rate increases as the Azone concentration increases,the it’s Absorption process fits Weibull equation. Conclusion The preparation technology of in-situ ginkgo biloba leaf nasal gel is viable.And Azone is the most effective sorbefacient for nasal mucosa Absorption.
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Key words:
- ginkgo biloba leaf extract /
- in-situ nasal gel /
- sorbefacients
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