郁可欣胶囊及其拆方对行为绝望抑郁症小鼠的影响
Comparison of antidepressant effects between Yukexin capsule and its components on mouse models of depression
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摘要: 目的: 比较郁可欣胶囊及拆方对行为绝望抑郁症动物的影响。 方法: 将小鼠分为5个组,对照组、氟西汀组、郁可欣组、贯叶连翘组及其他组分组。选择小鼠强迫游泳、悬尾应激及利舍平所致眼睑下垂小鼠绝望模型,观察不同处理对抑郁症状的影响。 结果: 郁可欣胶囊能缩短小鼠强迫悬尾及游泳的不动时间,并可对抗利舍平所致的小鼠眼睑下垂;拆方各组未能显著改善行为绝望动物的抑郁症状。 结论: 作为多种有效成分组成的郁可欣胶囊对绝望动物抑郁症状的改善显示较好的协同效应。Abstract: Objective: To compare the antidepressant effects of Yukexin capsule and its components on depressive mouse models. Methods: The mice were randomly divided into 5 groups:a control group,a fluoxetine group、a hypericum perforatum group,and the other components.By Using mouse tail suspension test(TST),mouse forced swim test (FST) and reserpine reversal,the antidepres- sant effects of Yukexin capsule and its components were observed.Result:Yukexin capsule shortened the immobility time of tailing suspension and furced swimming of the mice,and could also reverse the ptosis induced by reserpine,hut the symptoms were not notely affected by its components. Conclusion:: hese results suggest that Yukexin capsule,as a complex of active components,can obviously improve all the symptoms of the depressive models through the synergistie actions of the active components in it.
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