金黄地鼠和大鼠高血脂模型的应用研究

李林鹏; 孙浚雯; 曹永兵; 任天舒; 姜远英; 孙德好

留言板

尊敬的读者、作者、审稿人, 关于本刊的投稿、审稿、编辑和出版的任何问题, 您可以本页添加留言。我们将尽快给您答复。谢谢您的支持!

姓名
邮箱
手机号码
标题
留言内容
验证码

x 关闭永久关闭

重要提示

《药学实践与服务》杂志不接收生物战剂、毒剂相关内容的稿件。对于涉军信息类论文如需投稿，请务必投稿前电话或邮箱咨询。联系电话：021-81871323，邮箱：yxsjzzs@163.com。敬请谅解，谢谢配合！

《药学实践与服务》编辑部

重要通知

《药学实践与服务》杂志目前不收取审稿费、版面费、加急费等费用，如收到邮件声称是编辑部X编辑，要求加作者微信的，或填写编委登记申请表的，请谨防诈骗！

编辑部用于作者校稿时微信绑定的邮件是通过官方邮箱：yxsjzzs@163.com发送的，标题是《药学实践与服务》XML数字出版服务微信绑定，请区分开！如有疑虑，请联系编辑部，电话：021-81871323。

《药学实践与服务》编辑部

金黄地鼠和大鼠高血脂模型的应用研究

李林鹏, 孙浚雯, 曹永兵, 任天舒, 姜远英, 孙德好

文章导航 > 药学实践与服务 > 2007 > (6): 369-371

李林鹏, 孙浚雯, 曹永兵, 任天舒, 姜远英, 孙德好. 金黄地鼠和大鼠高血脂模型的应用研究[J]. 药学实践与服务, 2007, (6): 369-371.

引用本文:

李林鹏, 孙浚雯, 曹永兵, 任天舒, 姜远英, 孙德好. 金黄地鼠和大鼠高血脂模型的应用研究[J]. 药学实践与服务, 2007, (6): 369-371.

LI Lin-peng, SUN Jun-wen, CAO Yong-bing, REN Tian-shu, JIANG Yuan-ying, SUN De-hao. Studies on the application of the hyperlipemia model of golden hamster and Wistar rat[J]. Journal of Pharmaceutical Practice and Service, 2007, (6): 369-371.

Citation:

LI Lin-peng, SUN Jun-wen, CAO Yong-bing, REN Tian-shu, JIANG Yuan-ying, SUN De-hao. Studies on the application of the hyperlipemia model of golden hamster and Wistar rat[J]. Journal of Pharmaceutical Practice and Service, 2007, (6): 369-371.

金黄地鼠和大鼠高血脂模型的应用研究

1.
第二军医大学药学院药理学教研室,上海200433
2.
第二军医大学流行病学教研室,上海200433
3.
中国人民解放军第411医院,上海200081

Studies on the application of the hyperlipemia model of golden hamster and Wistar rat

1.
Department of Pharmacology,School of Pharmacy,Second Military Medical University,Shanghai 200433,China;Department of Epidemiology Second Military Medical University,Shanghai 200433,China;3.The 411th Hospital of PLA,Shanghai 200433,China
2.
Department of Pharmacology,School of Pharmacy,Second Military Medical University,Shanghai 200433,China;Department of Epidemiology Second Military Medical University,Shanghai 200433,China;3.The 411th Hospital of PLA,Shanghai 200433,China
3.
Department of Pharmacology,School of Pharmacy,Second Military Medical University,Shanghai 200433,China;Department of Epidemiology Second Military Medical University,Shanghai 200433,China;3.The 411th Hospital of PLA,Shanghai 200433,China

摘要: 目的:通过比较辛伐他汀在Wistar大鼠与金黄地鼠两种高血脂模型中的作用,分析两种高血脂模型的合理应用。方法:取Wistar大鼠和金黄地鼠各30只,大鼠体重200-230 g,金黄地鼠体重100-130 g,各随机分成空白对照组、模型对照组以及辛伐他汀组各10只。确认模型建立成功后,两给药组分别给予辛伐他汀10 mg/（kg.d）,并于给药第14、28天测定血清TC和LDL-C。分析辛伐他汀在两种动物高血脂模型中的作用。结果:辛伐他汀能抑制Wistar大鼠血脂升高的趋势和降低高血脂症金黄地鼠的血脂水平。Wistar大鼠对辛伐他汀的降脂作用较金黄地鼠更为敏感。结论:Wistar大鼠高血脂模型对辛伐他汀的降脂作用更为敏感,作为某些降血脂药物如他汀类活性筛选动物模型具有其优势。而金黄地鼠胆固醇的合成代谢与人类更为接近,其高血脂模型更有利于进行某些降血脂新药的临床前评价。
- 高血脂症 /
- 金黄地鼠 /
- Wistar大鼠 /
- 辛伐他汀
Abstract: Objective :To compare the effect of simvastatin in the hyperlipemia model of the golden hamster and the Wistar rat,discuss the reasonable application of the two animal hyperlipemia models. Methods :Thirty male golden hamsters weighing 100-130 g and thirty male Wistar rat weighing 200-300 g were respectively randomized into 3 groups with 10 in each,named as the normal group,model group and simvastatin group.After the models of hyperlipemia were established,the simvastatin groups were treated with the dosage of 10mg/（kg·d） simvastatin.Observe the effect of simvastatin on lipid level in the 14th and 28th day.Analysed the effect of simvastatin in the two hyperlipemia models. Results :Simvastatin decreased the lipid level of the two hyperlipemia model.The effect in Wistar rat is better than in golden hamster. Conclusion : Wistar rat is more susceptible to simvastatin than golden hamster.The hyperlipemia model of Wistar rat is adapt to the application of the selection of cholesterol-lowering drugs.The hyperlipemia model of golden hamster is suit to the before clinical research of the novel cholesterol-lowering drugs.
- hyperlipemia /
- hamster /
- Wistar rat /
- simvastatin

[1]	徐展飞, 李利, 佟向阳, 赵雪超. 汉防己甲素片对绝经后骨质疏松症患者首次唑来膦酸治疗后炎性细胞因子及急性期反应的影响 . 药学实践与服务, 2026, 44(4): 216-220. doi: 10.12206/j.issn.2097-2024.202508039
[2]	江冼芮, 吕佳颐. 临床药师参与血液透析患者抗体阴性Ⅱ型肝素相关性血小板减少症的药学监护实践 . 药学实践与服务, 2026, 44(9): 1-5. doi: 10.12206/j.issn.2097-2024.202603024
[3]	韩丹, 于飞, 朱昕桐, 武玥, 邵尉, 李睿旻. 医保情景下利司扑兰治疗儿童脊髓性肌萎缩症的经济学评价 . 药学实践与服务, 2026, 44(): 1-6. doi: 10.12206/j.issn.2097-2024.202601017
[4]	周小婷, 段禹, 李星源, 刘琴, 刘爱军. 中药治疗高尿酸血症的肾保护作用研究进展 . 药学实践与服务, 2026, 44(4): 167-172. doi: 10.12206/j.issn.2097-2024.202507029
[5]	李霞, 孙悦, 付晓菲. 临床药师参与注射用哌拉西林钠他唑巴坦钠致极重度血小板增多的病例分析 . 药学实践与服务, 2026, 44(5): 268-271. doi: 10.12206/j.issn.2097-2024.202601008
[6]	何琳, 成彦琼, 赵娟娟, 陆蕙兰, 杨骏, 陈方剑. 血通胶囊降血脂以及肝脏保护作用研究 . 药学实践与服务, 2026, 44(6): 289-295, 321. doi: 10.12206/j.issn.2097-2024.202502015
[7]	詹济华, 颜滢. 低蛋白血症对头孢哌酮舒巴坦血药浓度的影响 . 药学实践与服务, 2025, 43(7): 344-347. doi: 10.12206/j.issn.2097-2024.202309040
[8]	张俊丽, 李媛媛, 尹静, 杨鸿源, 白耀武. 咪达唑仑调节PINK1/PARKIN信号通路对缺血性脑卒中大鼠神经元损伤的影响 . 药学实践与服务, 2025, 43(6): 288-292, 312. doi: 10.12206/j.issn.2097-2024.202405024
[9]	竺东杰, 贺新征, 邹杰, 余史丹, 李红霞. 雷公藤甲素对大鼠脑缺血再灌注损伤的影响及机制研究 . 药学实践与服务, 2025, 43(7): 339-343, 361. doi: 10.12206/j.issn.2097-2024.202311021
[10]	冯一帆, 严啸东, 张文彬, 李炳锋, 郭美丽. 菸花苷长期给药对脑缺血再灌注损伤大鼠神经功能的影响 . 药学实践与服务, 2025, 43(5): 228-234. doi: 10.12206/j.issn.2097-2024.202407038
[11]	徐尧, 马春辉, 李志勇. 高血压对大鼠心血管纤维化及sFRP2表达的影响 . 药学实践与服务, 2025, 43(4): 180-184. doi: 10.12206/j.issn.2097-2024.202409055
[12]	魏雨辰, 田家盛, 王道鑫, 凌期盛, 王治, 缪朝玉. 烟酰胺单核苷酸口服给药对高血压大鼠的影响 . 药学实践与服务, 2025, 43(5): 213-221. doi: 10.12206/j.issn.2097-2024.202412006
[13]	张修平, 田家盛, 王道鑫, 李佳鑫, 王品, 缪朝玉. MT-1207对小鼠血糖、血脂和动脉粥样硬化的作用 . 药学实践与服务, 2024, 42(11): 487-494. doi: 10.12206/j.issn.2097-2024.202306011
[14]	王鹏, 陈顺, 赵逸, 高守红, 王志鹏. 卡培他滨致小鼠手足综合征模型的建立及评价 . 药学实践与服务, 2024, 42(9): 385-388, 398. doi: 10.12206/j.issn.2097-2024.202308045
[15]	丁千雪, 尚圣兰, 余梦辰, 余爱荣. 机器学习在肾病综合征患者他克莫司个体化用药中的应用 . 药学实践与服务, 2024, 42(6): 227-230, 243. doi: 10.12206/j.issn.2097-2024.202310007

点击查看大图

计量

文章访问数: 4539
HTML全文浏览量: 382
PDF下载量: 28
被引次数: 0

金黄地鼠和大鼠高血脂模型的应用研究

1. 第二军医大学药学院药理学教研室,上海200433

2. 第二军医大学流行病学教研室,上海200433

3. 中国人民解放军第411医院,上海200081

收稿日期: 2007-04-11

关键词:

摘要: 目的:通过比较辛伐他汀在Wistar大鼠与金黄地鼠两种高血脂模型中的作用,分析两种高血脂模型的合理应用。方法:取Wistar大鼠和金黄地鼠各30只,大鼠体重200-230 g,金黄地鼠体重100-130 g,各随机分成空白对照组、模型对照组以及辛伐他汀组各10只。确认模型建立成功后,两给药组分别给予辛伐他汀10 mg/（kg.d）,并于给药第14、28天测定血清TC和LDL-C。分析辛伐他汀在两种动物高血脂模型中的作用。结果:辛伐他汀能抑制Wistar大鼠血脂升高的趋势和降低高血脂症金黄地鼠的血脂水平。Wistar大鼠对辛伐他汀的降脂作用较金黄地鼠更为敏感。结论:Wistar大鼠高血脂模型对辛伐他汀的降脂作用更为敏感,作为某些降血脂药物如他汀类活性筛选动物模型具有其优势。而金黄地鼠胆固醇的合成代谢与人类更为接近,其高血脂模型更有利于进行某些降血脂新药的临床前评价。

English Abstract

Studies on the application of the hyperlipemia model of golden hamster and Wistar rat

1. Department of Pharmacology,School of Pharmacy,Second Military Medical University,Shanghai 200433,China;Department of Epidemiology Second Military Medical University,Shanghai 200433,China;3.The 411th Hospital of PLA,Shanghai 200433,China

2. Department of Pharmacology,School of Pharmacy,Second Military Medical University,Shanghai 200433,China;Department of Epidemiology Second Military Medical University,Shanghai 200433,China;3.The 411th Hospital of PLA,Shanghai 200433,China

3. Department of Pharmacology,School of Pharmacy,Second Military Medical University,Shanghai 200433,China;Department of Epidemiology Second Military Medical University,Shanghai 200433,China;3.The 411th Hospital of PLA,Shanghai 200433,China

Received Date: 2007-04-11

Keywords:

Abstract: Objective :To compare the effect of simvastatin in the hyperlipemia model of the golden hamster and the Wistar rat,discuss the reasonable application of the two animal hyperlipemia models. Methods :Thirty male golden hamsters weighing 100-130 g and thirty male Wistar rat weighing 200-300 g were respectively randomized into 3 groups with 10 in each,named as the normal group,model group and simvastatin group.After the models of hyperlipemia were established,the simvastatin groups were treated with the dosage of 10mg/（kg·d） simvastatin.Observe the effect of simvastatin on lipid level in the 14th and 28th day.Analysed the effect of simvastatin in the two hyperlipemia models. Results :Simvastatin decreased the lipid level of the two hyperlipemia model.The effect in Wistar rat is better than in golden hamster. Conclusion : Wistar rat is more susceptible to simvastatin than golden hamster.The hyperlipemia model of Wistar rat is adapt to the application of the selection of cholesterol-lowering drugs.The hyperlipemia model of golden hamster is suit to the before clinical research of the novel cholesterol-lowering drugs.

李林鹏, 孙浚雯, 曹永兵, 任天舒, 姜远英, 孙德好. 金黄地鼠和大鼠高血脂模型的应用研究[J]. 药学实践与服务, 2007, (6): 369-371.

引用本文:

李林鹏, 孙浚雯, 曹永兵, 任天舒, 姜远英, 孙德好. 金黄地鼠和大鼠高血脂模型的应用研究[J]. 药学实践与服务, 2007, (6): 369-371.

Citation:

全文HTML

下载: 全尺寸图片幻灯片

返回文章

用微信扫码二维码

分享至好友和朋友圈

主管、主办: 中国人民解放军海军军医大学地址: 上海市杨浦区国和路325号邮政编码: 200433

电话: （021）81871324,81871397 E-mail: yxsjzzs@163.com

网站备案号沪ICP备05003363号-1

本系统由北京仁和汇智信息技术有限公司开发

留言板

金黄地鼠和大鼠高血脂模型的应用研究

Studies on the application of the hyperlipemia model of golden hamster and Wistar rat

计量

出版历程

金黄地鼠和大鼠高血脂模型的应用研究

1. 第二军医大学药学院药理学教研室,上海200433 2. 第二军医大学流行病学教研室,上海200433 3. 中国人民解放军第411医院,上海200081

English Abstract

Studies on the application of the hyperlipemia model of golden hamster and Wistar rat

全文HTML

目录

1. 第二军医大学药学院药理学教研室,上海200433

2. 第二军医大学流行病学教研室,上海200433

3. 中国人民解放军第411医院,上海200081