糙叶败酱中环烯醚萜苷元成分抗结肠癌作用的实验研究
Effects of the iridoid aglycones from Patrinia scabra on colon cancer
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摘要: 目的: 研究糙叶败酱中环烯醚萜苷元成分体外抗小鼠结肠癌细胞株C26作用和对小鼠结肠癌(C26)移植性肿瘤的作用。 方法: 采用四唑盐(MTT)比色法研究糙叶败酱中环烯醚萜苷元PS-Ⅰ和BJ3401对小鼠结肠癌细胞株C26生长的影响;于F1小鼠皮下注射小鼠结肠癌细胞株(C26)建立小鼠结肠癌移植性肿瘤模型,观察糙叶败酱中总环烯醚萜苷元对结肠癌移植性肿瘤小鼠的影响。 结果: 环烯醚萜苷元PS-Ⅰ、BJ3401可显著抑制小鼠结肠癌细胞株C26的生长,并且具有一定的剂量依赖关系;总环烯醚萜苷元可显著减轻荷瘤鼠瘤重。 结论: 糙叶败酱中环烯醚萜苷元具有抗结肠癌的作用。
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关键词:
- 糙叶败酱 /
- 抗肿瘤 /
- 环烯醚萜苷元 /
- 人结肠癌细胞株C26
Abstract: Objective:To study the effects of the iridoid aglycones from Patrinia scabra on mouse colon cancer cell line C26 in vitro and on transplanting-tumor of mouse colon cancer cell C26. Methods: The effects of the iridoid aglycones from Patrinia scabra(PS-I, BJ3401)on mouse colon cancer cell line C26 were studied by MTF experiment,the transplanting-tumor model of mouse colon cancer was established by hypodermic inoculating the mouse colon cancer cell lines C26 into the FI mice. Results: The iridoid aglycones PS -I and BJ3401 could significantly inhibit proliferation of C26 cell line in a doge-dependent manner,gross iridoid aglycones could sig- nificantly lessen the weight of the transplanting-tumor in mice.Conclusion :The iridoid aglycones from Patrinia scabra have anti-colon carcinoma activity.
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