甲苯磺酸托氟沙星胶囊溶出度测定方法的研究
Study of determination method of dissolution of tosufloxacin tosylate capsules
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摘要: 本文报道用盐酸液(0.1mol/L)作溶剂,以转篮法测定甲苯磺酸托氟沙星胶囊的溶出度,按本实验测得的吸收系数(E1cm1%)为738计算主药的溶出量.本法简便、灵敏、准确,甲苯磷酸托氟沙星的平均回收率为100.2%,RSD=0.45%(n=8).
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关键词:
- 甲苯磺酸托氟沙星胶囊 /
- 溶出度 /
- 转篮法
Abstract: A basket method was employed for determination of dissolution Of tosufloxacin tosylate capsules with hydrochloride acid solution (0.1mol/L) as medium. Calculated the dissolution of tesufloxacin tosylate,taking 738 as the value of A(1%, 1cm) that it was determinated by this test. This method was simple and accurate.The average recovery was 100.2%, RSD=0.45% (n=8).-
Key words:
- tosufloxacin tosylate capsules /
- dissolution /
- basket method
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