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2024 Vol. 42, No. 4

Cover Catalogue
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Research progress on hepatic macrophages and liver fibrosis
JIANG Haiyan, ZHONG Fangfang, ZHANG Junping
2024, 42(4): 135-140. doi: 10.12206/j.issn.2097-2024.202209030
Abstract(6054) HTML (2444) PDF (1023KB)(73)
Abstract:
Liver fibrosis is a repair response to chronic liver injury caused by various etiologies. Its continuous progression can develop into liver cirrhosis or even hepatocellular carcinoma, eventually leading to liver failure. Currently, there is no effect...
Upregulation of α1-acidglycoprotein to ameliorate hepatocyte lipid accumulation by Astragaloside derivative HHQ16
LI Xiang, DAI Xianmin, LIU Xia, SUN Yang
2024, 42(4): 141-146. doi: 10.12206/j.issn.2097-2024.202309026
Abstract(4417) HTML (1068) PDF (1314KB)(13)
Abstract:
Objective  To investigate the effect and mechanism of HHQ 16, a derivative of astragaloside Ⅳ, on hepatocyte lipid accumulation.   Methods  Free fatty acids were used to stimulate lipid hepatocyte accumulation. Triglyceride and Oil Red O staining ...
Genotoxicity evaluation of HMS-01
CHEN Yi, SUN Qingyan, LI Xiang, SUN Yang, LIU Xia
2024, 42(4): 147-150, 156. doi: 10.12206/j.issn.2097-2024.202308061
Abstract(2389) HTML (1323) PDF (1217KB)(11)
Abstract:
Objective   To provide a toxicological basis for HMS-01 in future clinical trials, through genotoxicity testing of safety evaluation.   Methods   The genotoxicity of HMS-01 was evaluated by Bacterial Reverse Mutation Assay (Ames test) with Salmone...
Study on antifungal effect of demethylzelamaldehyde in vitro
HAN Lei, ZHONG Hua, WANG Xinrong, WANG Yan
2024, 42(4): 151-156. doi: 10.12206/j.issn.2097-2024.202310011
Abstract(2039) HTML (983) PDF (1427KB)(10)
Abstract:
Objective  To study the antifungal effect of demethylzelamaldehyde in vitro.   Methods  The minimum inhibitory concentrations (MIC) of demethylzeylasteral and fluconazole against 23 fungal strains were determined by micro liquid dilution method. T...
Potential mechanism of Babao Dan in the treatment of hepatocellular carcinoma based on network pharmacology
ZHU Xinyu, BAI Haoran, ZHAO Naping, QI Dachuan, WEI Lixin, ZHANG Li
2024, 42(4): 157-164. doi: 10.12206/j.issn.2097-2024.202401061
Abstract(2421) HTML (1338) PDF (1831KB)(22)
Abstract:
Objective   To explore the potential mechanism of Babao Dan on primary liver cancer based on network pharmacology.   Methods   First, the diethylnitrosamine-induced hepatocellular carcinoma rat(HCC)model was used to observe the effects of Babao Da...
The increasement of blood METRNL protein by insulin sensitizer rosiglitazone
XU Fei, CHEN Jin, LI Zhiyong
2024, 42(4): 165-168. doi: 10.12206/j.issn.2097-2024.202308053
Abstract(1876) HTML (859) PDF (1284KB)(10)
Abstract:
Objective  To investigate the effect of insulin sensitizer rosiglitazone on blood METRNL levels.   Methods  After fed with high fat diet (HFD) for 3 months, obese mice were treated with rosiglitazone for 1 month. Glucose tolerance was tested with ...
Analysis of tissue distribution of metabolites in Crocus sativus L. corms based on DESI mass spectrometry imaging technique
CHEN Xi, XIE Xingguang, FENG Kunmiao, LU Yingjie, HAN Ting
2024, 42(4): 169-172, 180. doi: 10.12206/j.issn.2097-2024.202310055
Abstract(2329) HTML (951) PDF (1565KB)(12)
Abstract:
Objective  To explore the distribution characteristics of endogenous metabolites in Crocus sativus L. corms from different origins.   Methods  A method based on desorption electrospray ionization mass spectrometry imaging and optimized sample pret...
Mechanisms of Shexiang Baoxin Pill in homo-therapy for heteropathy in type 2 diabetes mellitus and coronary heart disease based on network pharmacology
ZHU Zifan, WANG Zhicong, XIE Bin, LIU Runhui
2024, 42(4): 173-180. doi: 10.12206/j.issn.2097-2024.202305037
Abstract(3926) HTML (1966) PDF (2014KB)(27)
Abstract:
Objective  To probe into the mechanism of Shexiang Baoxin Pill in homo-therapy for heteropathy for type 2 diabetes mellitus (T2DM) and coronary heart disease (CHD) based on network pharmacology.   Methods  All chemical components and action target...