2024 Vol. 42, No. 4
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2024, 42(4): 135-140.
doi: 10.12206/j.issn.2097-2024.202209030
Abstract:
Liver fibrosis is a repair response to chronic liver injury caused by various etiologies. Its continuous progression can develop into liver cirrhosis or even hepatocellular carcinoma, eventually leading to liver failure. Currently, there is no effect...
Liver fibrosis is a repair response to chronic liver injury caused by various etiologies. Its continuous progression can develop into liver cirrhosis or even hepatocellular carcinoma, eventually leading to liver failure. Currently, there is no effect...
2024, 42(4): 141-146.
doi: 10.12206/j.issn.2097-2024.202309026
Abstract:
Objective To investigate the effect and mechanism of HHQ 16, a derivative of astragaloside Ⅳ, on hepatocyte lipid accumulation. Methods Free fatty acids were used to stimulate lipid hepatocyte accumulation. Triglyceride and Oil Red O staining ...
2024, 42(4): 147-150, 156.
doi: 10.12206/j.issn.2097-2024.202308061
Abstract:
Objective To provide a toxicological basis for HMS-01 in future clinical trials, through genotoxicity testing of safety evaluation. Methods The genotoxicity of HMS-01 was evaluated by Bacterial Reverse Mutation Assay (Ames test) with Salmone...
2024, 42(4): 151-156.
doi: 10.12206/j.issn.2097-2024.202310011
Abstract:
Objective To study the antifungal effect of demethylzelamaldehyde in vitro. Methods The minimum inhibitory concentrations (MIC) of demethylzeylasteral and fluconazole against 23 fungal strains were determined by micro liquid dilution method. T...
2024, 42(4): 157-164.
doi: 10.12206/j.issn.2097-2024.202401061
Abstract:
Objective To explore the potential mechanism of Babao Dan on primary liver cancer based on network pharmacology. Methods First, the diethylnitrosamine-induced hepatocellular carcinoma rat(HCC)model was used to observe the effects of Babao Da...
2024, 42(4): 165-168.
doi: 10.12206/j.issn.2097-2024.202308053
Abstract:
Objective To investigate the effect of insulin sensitizer rosiglitazone on blood METRNL levels. Methods After fed with high fat diet (HFD) for 3 months, obese mice were treated with rosiglitazone for 1 month. Glucose tolerance was tested with ...
2024, 42(4): 169-172, 180.
doi: 10.12206/j.issn.2097-2024.202310055
Abstract:
Objective To explore the distribution characteristics of endogenous metabolites in Crocus sativus L. corms from different origins. Methods A method based on desorption electrospray ionization mass spectrometry imaging and optimized sample pret...
2024, 42(4): 173-180.
doi: 10.12206/j.issn.2097-2024.202305037
Abstract:
Objective To probe into the mechanism of Shexiang Baoxin Pill in homo-therapy for heteropathy for type 2 diabetes mellitus (T2DM) and coronary heart disease (CHD) based on network pharmacology. Methods All chemical components and action target...