2020 Vol. 38, No. 4
Display Method:
2020, 38(4): 289-295.
doi: 10.12206/j.issn.1006-0111.202004023
Abstract:
Objective To investigate the pharmacological mechanism of Chaihudaxiong mixture in the treatment of coronavirus disease 2019 (COVID-19) based on a network pharmacology approach. Methods The effective ingredients and targets of Chaihudaxiong mix...
2020, 38(4): 296-300, 306.
doi: 10.12206/j.issn.1006-0111.201910073
Abstract:
Objective To investigate the mechanism of leflunomide (LEF) in regulating pulmonary fibrosis by regulating microRNA (miR)-449a. Methods Human lung fibroblasts MRC-5 were divided into 6 groups: control group, LEF group, LEF+mimic group, mimic gr...
2020, 38(4): 301-306.
doi: 10.12206/j.issn.1006-0111.201910082
Abstract:
Objective To prepare a wound dressing using nitrocellulose as a membrane and optimize its formulation. Methods Partial analysis was performed on commercial available products. The wound dressings were prepared by using nitrocellulose as a film-...
2020, 38(4): 307-311, 317.
doi: 10.12206/j.issn.1006-0111.201911075
Abstract:
Objective In order to improve the problems of poor water-solubility and low bioavailability of ocular tacrolimus, a cationic nanoemulsion in-situ gel of tacrolimus was developed and its drug release behavior in vitro was studied to provide a basis ...
2020, 38(4): 312-317.
doi: 10.12206/j.issn.1006-0111.202002007
Abstract:
Objective To compare the pharmacokinetics of moxifloxacin (MXF) administered orally in the plasma and lung tissues of rats with pneumonia infected by Streptococcus pneumoniae (S.p) and normal rats. Methods To establish a model of Streptococcus ...
2020, 38(4): 318-321.
doi: 10.12206/j.issn.1006-0111.202003141
Abstract:
Objective To analyze the metabolic differences of 11C-flumazenil (11C-FMZ) with different specific radioactivity by detecting the percentage proportion of the main metabolites in vivo. Methods 5 male and 5 female volunteers with average age of ...
2020, 38(4): 322-327.
doi: 10.12206/j.issn.1006-0111.201909078
Abstract:
Objective To evaluate the pharmacodynamics and safety of the self-made compound ketoconazole ointment. Methods Using the disk diffusion test, 6 kinds of fungi and 2 kinds of bacteria were selected to investigate the effect of the self-made oint...
2020, 38(4): 328-333, 345.
doi: 10.12206/j.issn.1006-0111.201912092
Abstract:
Objective To avoid the accumulation of copper sulfide (CuS) nanoparticles, prepare and optimize CuS nanoparticles, analyze the factors affecting the particle size and evaluate their photothermal properties. Methods Based on the single factor st...
2020, 38(4): 334-339.
doi: 10.12206/j.issn.1006-0111.201911107
Abstract:
Objective To investigate the clinical efficacy of cyclosporine injection in subclinical or critical treatment of renal transplant patients, and to establish an individualized dosage regimen of cyclosporine injection by studying the effects of nine...
2020, 38(4): 340-345.
doi: 10.12206/j.issn.1006-0111.202001077
Abstract:
Objective To compare the effects of vitamin K1 (VK1), vitamin K2 (MK4), vitamin K2 (MK7) and vitamin K3 (VK3) on bone formation and bone absorption. Methods Osteoblasts were isolated from calvaria of newborn rats and osteoclasts were induced by...
2020, 38(4): 346-349.
doi: 10.12206/j.issn.1006-0111.201911013
Abstract:
Objective To optimize the extraction process of main iridoid glycosides in Damnacanthus officinarum Huang and evaluate the antioxidant activity of Damnacanthus officinarum Huang in vitro. Methods The classical heating-reflux extraction method w...
2020, 38(4): 350-353, 378.
doi: 10.12206/j.issn.1006-0111.202001063
Abstract:
Objective To establish a method for the determination of propylthiouracil in human plasma by UPLC-MS/MS and provide methodological basis for therapeutic drug monitoring (TDM) and bioequivalence test (BE) in clinical. Methods The chromatographic...
2020, 38(4): 354-358, 382.
doi: 10.12206/j.issn.1006-0111.202001025
Abstract:
Objective To optimize the process of ultrasonic extraction of polysaccharide in Anoectochilus roxburghii and to investigate the method of protein removal. Methods The extraction rate of polysaccharide was used as the detection index. On the bas...
2020, 38(4): 359-363.
doi: 10.12206/j.issn.1006-0111.202001083
Abstract:
Objective To optimize the extraction method and develop the detection method of ginsenoside Rb1 and astragaloside Ⅳ in Weikang granules. Methods The extraction process of ginsenoside Rb1 and astragaloside Ⅳ in Weikang granules were optimized by...
2020, 38(4): 364-367.
doi: 10.12206/j.issn.1006-0111.202002011
Abstract:
Objective To establish a fast detection method of sodium aescinate by using near infrared (NIR) spectroscopy analysis method for the determination of the content of sodium aescinate for injection. Methods OPUS software was used to optimize the ...
2020, 38(4): 368-372.
doi: 10.12206/j.issn.1006-0111.201912170
Abstract:
Objective To study the clinical effect of Yaotongning capsule combined with etoricoxib for the pain and inflammation of lumbar vertebrae in elderly patients with lumbar osteoarthritis. Methods 120 elderly patients with lumbar osteoarthritis adm...
2020, 38(4): 373-378.
doi: 10.12206/j.issn.1006-0111.202001054
Abstract:
Objective To analyze the impact of “4+7” City Drug Centralized Procurement Program on the utilization of cardiovascular medicines, and to provide a reference for optimizing the policy of generic medicines as substitutes for original medicines. Me...
2020, 38(4): 379-382.
doi: 10.12206/j.issn.1006-0111.202004095
Abstract:
Objective To investigate and analyze the inpatient use of narcotic drugs, provide reference for clinical norms and rational use of narcotic drugs. Methods The narcotic prescription number, usage and cost were analyzed statistically. The inpatie...
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