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2017 Vol. 35, No. 3

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Advance in resistance mechanism of cancer stem cells therapy
CAO Mengxue, SUN Fan, LIN Houwen
2017, 35(3): 193-196,247. doi: 10.3969/j.issn.1006-0111.2017.03.001
Abstract:
Lung cancer is the leading cause of cancer deaths worldwide. Recurrence and metastasis are the primary reasons for its poor prognosis. Growing evidence has proposed that lung cancer may be driven by cancer stem cells (CSCs), which may be responsible ...
The research status of the drug therapy for inflammatory bowel disease
BIAN Yingying, WANG Jie, LI An, KAI Guoyin, LU Yiming
2017, 35(3): 197-200,228. doi: 10.3969/j.issn.1006-0111.2017.03.002
Abstract(4528) PDF (1390KB)(1219)
Abstract:
Research on the inflammatory bowel disease(IBD) is a hot topic in the field of digestive system disease. IBD mainly consists of ulcerative colitis(UC) and Crohn's disease(CD). The pathogenesis of IBD has not been fully understood. So far, there is no...
Research progress in drugs for chronic obstructive pulmonary disease therapy
LUO Zhicheng, WU Guozhen, YUAN Xing
2017, 35(3): 201-204,242. doi: 10.3969/j.issn.1006-0111.2017.03.003
Abstract(3640) PDF (1387KB)(1198)
Abstract:
Chronic obstructive pulmonary disease (COPD) is a chronic respiratory disease characterized by incompletely reversible airflow limitation and progressive course. The pathogenesis of COPD is complicated. Clinical symptoms include declining pulmonary f...
Progress in research of sodium prasterone sulfate in vaginal atrophy
QIN Jinling, SUN Deyou, DING Minghe, LIU Wei, FAN Yanbo, XIA Jun
2017, 35(3): 205-207,274. doi: 10.3969/j.issn.1006-0111.2017.03.004
Abstract(4742) PDF (1638KB)(1678)
Abstract:
Sodium prasterone sulfate (DHEAS) and dehydroepiandrosterone (DHEA) are endogenous steroid compounds, which are synthesized and secreted by adrenal gland. They are the precursors of steroid hormones,including sex hormone. Based on intracrine theory,t...
Bioinformatics analysis of laccases involved in active lignans' biosynthesis in Isatis indigotica
CHEN Liang, LI Qing, CHEN Junfeng, FENG Jingxian, ZHANG Lei, CHEN Wansheng
2017, 35(3): 208-214. doi: 10.3969/j.issn.1006-0111.2017.03.005
Abstract:
Objective Identifying laccases, as one of the key synthetases in the lariciresinol biosynthetic pathway, by analyzing the transcriptome sequencing results in Isatis indigotica would provide a dependable foundation for later functional study of Isati...
TLC-SERS for detection of the dyed Croci Stigma
ZHANG Binbin, SHI Yi, CHEN Hui, ZHU Qingxia, LU Feng
2017, 35(3): 215-218. doi: 10.3969/j.issn.1006-0111.2017.03.006
Abstract(4134) PDF (4636KB)(1044)
Abstract:
Objective To establish a thin layer chromatography-surface-enhanced Raman scattering(TLC-SERS) method for the detection of dyed Croci Stigma. Method The dyed Croci Stigma was wetted by ethanol and pressed on TLC plate sprayed with Silver sol. The ...
Preparation and characterization of co-delivery of doxorubicin and elacridar in nanoparticles
CHEN Dazhong, GAO Jie, XIE Fangyuan, ZHANG He, LU Ying, ZOU Hao, ZHONG Yanqiang
2017, 35(3): 219-223,251. doi: 10.3969/j.issn.1006-0111.2017.03.007
Abstract(4216) PDF (6880KB)(1261)
Abstract:
Objective To establish methods for the determination of doxorubicin and elacridar, and prepare PLGA nanoparticles for the co-delivery of doxorubicin and elacridar. Methods Ultraviolet spectrophotometry (UV) and high performance liquid chromatograp...
Regulation and control of transcription factor Cup2 on Cu2+ metabolism and oxidative stress in Candida albicans
ZHANG Jinyu, WANG Lihong, QIN Yulin, ZHANG Lulu, JIANG Yuanying, CAO Yongbing
2017, 35(3): 224-228. doi: 10.3969/j.issn.1006-0111.2017.03.008
Abstract:
Objective To detect the transcription factors of copper ion (Cu2+) metabolism and oxidative stress by Candida albicans knocked down different transcription factors. Methods Spot assay, growth curve were used. Results The sensitivity to Cu2+ in C...
Inhibitory effect of myricetin on the metastasis of human renal cell carcinoma
TAN Haisong, YE Chen, WU Dengshuang, BAO Yi, LIU Bing, HE Yi, WANG Linhui
2017, 35(3): 229-232,237. doi: 10.3969/j.issn.1006-0111.2017.03.009
Abstract:
Objective To evaluate the role of myricetin in the metastasis of human renal cancer ACHN cells both in vitro and in vivo. Methods With different concentration of myricetin (25, 50, 100 μmol/L) acting on ACHN cells, the cell viability, migration an...
Cuprous oxide nanoparticles effect on the epithelial-mesenchymal transition of B16 cells
LI Xiangui, ZHAN Jieqiong, LI Xinfang, SHE Lan, MA Zhiqiang, SUN Linhong, YANG Feng
2017, 35(3): 233-237. doi: 10.3969/j.issn.1006-0111.2017.03.010
Abstract:
Objective To research the epithelial-mesenchymal transition (EMT) effects of cuprous oxide nanoparticles (CONPs) on melanoma. Methods Cuprous oxide nanoparticles were prepared hydrothermally.The B16 cells were cultured with cuprous oxide nanoparti...
Phenylethanoid glycosides of Pedicularis muscicola ameliorate high altitude-induced memory impairment by activating mTOR signal pathway
WANG Tao, ZHOU Baozhu, QIU Yan, LI Maoxing, LIU Yantong
2017, 35(3): 238-242. doi: 10.3969/j.issn.1006-0111.2017.03.011
Abstract:
Objective To investigate the mechanism of phenylethanoid glycosides of pedicularis muscicola Maxim ameliorating high altitude memory impairmentby activating mTOR signal pathway. Methods 60 clean male Wistar rats were randomly divided into normoxic...
Preparation of the etoposide chitosan micelle and the effect of chitosan on etoposide intestinal absorption
CHEN Song, WANG Yujie, WANG Huan, YUAN Yongfang
2017, 35(3): 243-247. doi: 10.3969/j.issn.1006-0111.2017.03.012
Abstract:
Objective To prepare the etoposide chitosan micelle, and investigate the effect of chitosan on etoposide intestinal absorption. Methods The etoposide chitosan micelle was prepared by dialysis. The drug encapsulation efficiency and drug loading eff...
The methodology validation and content assay of total polysaccharides in Pudi Enema
WANG Yihong, CHEN Jinshan, XU Caiyan, ZHENG Shaozhong
2017, 35(3): 248-251. doi: 10.3969/j.issn.1006-0111.2017.03.013
Abstract:
Objective To establish the assay method for the total polysaccharide in Pudi Enema. Methods Phenol-sulfuric acid method was used for chromogenic reaction. The content of total polysaccharide was measured by UV spectrophotometry at 488.8 nm. Resul...
Qualitative identification and quantitative determination of Fufang Shenghua granules
CHEN Hua, YU Botao, JIN Weihua, PU Zhiqiang, SONG Zonghui, FAN Kaihua
2017, 35(3): 252-255. doi: 10.3969/j.issn.1006-0111.2017.03.014
Abstract:
Objective To improve quality standard of Fufang Shenghua granules. Methods TLC was used to identify chief components in the preparation, Radix et Rhizoma Glycyrrhizae and Salvia Miltiorrhiza. HPLC was applied to identify Amarogentin and to determi...
Study on quality standard of Compound Belladonna Mixture
TAO Xiaoxuan, LI Gang, XU Lan, ZHANG Qiang
2017, 35(3): 256-258. doi: 10.3969/j.issn.1006-0111.2017.03.015
Abstract:
Objective To improve the quality standard for Compound Belladonna Mixture. Methods TLC was used for the qualitative identification of morphine. HPLC was used for the content of morphine in the Compound Belladonna Mixture. Results Morphine could ...
Determination of pueratin in Jiangzhi Hugan capsule by HPLC
ZHENG Wei, NI Dongjie, WEI Qing, XIANG Hui, HU Lanlan, SUN Liang
2017, 35(3): 259-261. doi: 10.3969/j.issn.1006-0111.2017.03.016
Abstract(3700) PDF (968KB)(673)
Abstract:
Objective To develop a HPLC method for determination of pueratin. Methods The separation was carried out on a Waters Symmetry C18 column(4.6 mm×250 mm, 5 μm), the mobile phase was composed of acetonitrile and 1% formic acid(11:89), the detection w...
Clinical observation of piperacillin/tazobactam's optimized regimen formulated by T >MIC% for 59 patients with P.aeruginosa infection
LI Yi, SONG Xiangqing, GUI Wandi
2017, 35(3): 262-266. doi: 10.3969/j.issn.1006-0111.2017.03.017
Abstract(4132) PDF (728KB)(974)
Abstract:
Objective To observe the treatment efficacy of piperacillin/tazobactam regime for P.aeruginosa infection formulated by the method of the ratio of T above MIC (T >MIC%). Methods 59 hospitalized patients with P.aeruginosa infection were diagnosed by...
Clinical efficacy of Scrophularia ningpoensis granules combined with fosinopril for congestive heart failure
QIAN Yujun, QIN Chunxia, SUN Lili, DING Huamin, LI Yiming, LI Tiejun
2017, 35(3): 267-269. doi: 10.3969/j.issn.1006-0111.2017.03.018
Abstract(3860) PDF (698KB)(925)
Abstract:
Objective To evaluate the efficacy of Scrophularia ningpoensis granules combined with fosinopril in treatment of congestive heart failure. Methods 60 congestive heart failure patients were randomly divided into 2 groups, 30 patients in the treatme...
Reoperation for recurrence after resection of primary hepatocellular carcinoma: a case report and literature review
GUO Lingling, DING Yongmei, ZHANG Qian
2017, 35(3): 270-274. doi: 10.3969/j.issn.1006-0111.2017.03.019
Abstract(3256) PDF (727KB)(882)
Abstract:
Hepatocellular carcinoma (HCC) is a malignant tumor with high incidence worldwide, especially in China. Surgical resection is the standard therapy for HCC. With the developments of surgical and supportive techniques, perioperative risk is significant...
Current status of pharmaceutical management in traditional Chinese medicine pharmacy in state-run medical institutions in Jiading district, Shanghai
LIU Duo, WEI Haiying, QIAN Fang, GU Yan, ZHANG Jufang, GAO Yan, SU Hongmei
2017, 35(3): 275-278,288. doi: 10.3969/j.issn.1006-0111.2017.03.020
Abstract(3629) PDF (1382KB)(1005)
Abstract:
Objective To evaluate the current status of traditional Chinese medicine(TCM) pharmacy in state-run hospitals in Jiading district in order to improve the quality of TCM pharmacy management. Methods 16 medical institutions were investigated. Among ...
Pharmacy administration in pilot hospitals with the separation policy between medicine and pharmacy
LIAN Luying, LI Hui, LIU Ying
2017, 35(3): 279-281. doi: 10.3969/j.issn.1006-0111.2017.03.021
Abstract(3364) PDF (687KB)(910)
Abstract:
Objective To provide the supporting evidence for the separation policy between medicine and pharmacy by investigating the effect of the policy on pharmacy administration in four three grade hospitals. Methods The drug supply chain management was r...
Meta-analysis of 10 mg policosanol versus an equal dose of atorvastatin on the lipid-lowering efficacy in patients with dyslipidemia
YING Yin, LU Xuliang, DONG Weiyi, SONG Hongtao
2017, 35(3): 282-288. doi: 10.3969/j.issn.1006-0111.2017.03.022
Abstract:
Objective To evaluate the lipid-lowering effect of 10 mg policosanol versus an equal dose of atorvastatinin patients with dyslipidemia. Method Databases such as VIP,Wanfang,CNKI,Cochrance Library,PubMed,Web of Science and EMBASE were searched for ...